YouSaid · the spoken record

Dr. Alex Tatem

lines on the record: 122
first: 2026-04-20
most recent: 2026-04-20
sittings or episodes: 1
sources: podcast

Every line below is reproduced as it was said and linked to the record it came from. Nothing here is summarised or generated. Directory · Search · Corrections

“And so there's concern that that was at play as well. And so there is not a great paper trail, and there's not a great explanation why. And that's something that's been iterated by our current administration from RFK himself. He himself has characterized that move done in 2023 as being illegal.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“That's a great question. So officially, what happened is there was a meeting where they brought together the experts at the time and they said there is insufficient data for us to say that these are safe because again they had not gone through the full FDA approval process. And so as a result of lacking that data, we're going to say that they're too dangerous. Now there wasn't any evidence of any of that in the population. These were widely used at the time. Potentially we had commercial pharmaceutical companies saying, well, hey, this is people spending money on a compound, on something that isn't coming to us. So, hey, like we love medicine, but maybe only when it's our medicine.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“An adverse event is a patient has a terrible side effect. They call you, they have an allergic reaction to something, they call, they've got shortness of breath, and it's a direct result of the medication that you gave them. It was working. It was working. And by all accounts seemed to be incredibly safe.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, so they were able to stimulate the hunger response, and patients were Again, it had gone through some clinical trials, but was never taken all the way to commercial. And so it was never going to be available from CVS or Walgreens, but you could get it from a compounding pharmacy. And so that was one that made a big difference for us. We also had other peptides. So GHRP2 and GHRP6 were some of the ones we were using at that time. Those are growth hormone-releasing peptides that stimulate the release of your body's natural growth hormone, which can help with tissue repair. It can also help with fat loss and with building muscle. We also had BPC-157, and we had derivatives like thymus and beta-4. These are also compounds that can help stimulate angiogenesis, so making new blood vessels, all right, and tissue repair. So if we have a patient that's injured themselves, maybe we could help them get back at life faster. These were all things that were used very commonplace for many years. And truthfully, they weren't super popular at the time. We were just used.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“Very much so. Again, you have to use the right key for the right lock, okay? But I think a really good example, all right. So there is a compound that is not technically a peptide. It is a small molecule, but it was lumped in with all of these and was the victim to the same process something called MK677, also known as Ibutamorin. So this is a small molecule, but when a patient takes it, it's orally available. It binds to this receptor called Grellin, and it actually stimulates the release of significant growth hormone. But what was really interesting is that it would actually stimulate hunger, a profound amount. And all of a sudden, patients that were struggling with cachia, okay, so being very, very thin, very malnourished, maybe they're going through cancer treatment. Absolutely.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“Essentially, what it did is it gave an assignment to each one of these compounds. It was either going to be category one, which is you can compound this. This is on our specific list of approved compoundable drug ingredients. Number two was, hey, we see some negative safety signals here. You cannot make this. Okay, something goes in category two. It's forbidden. And then we have category three, which is we just need more information. All of these original compounds, these peptides that we're so interested in now were originally on that first list, category one. All right. And so they were able to be compounded. We could prescribe them in patients. I prescribed them to patients. All right. From 2014 onward. But then in 2023, the FDA at that time switched all of those peptides, 19 of them that were popular to category two, and then they were banned. Overnight, we got notifications in our email inboxes from our compounding pharmacy partner saying, hey, we can't make this anymore.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“Absolutely not, okay? Because you have shareholders and you have to make payroll. And so because drug development is so expensive, there is no incentive for commercial pharmaceutical companies to pursue the development of these compounds. And then on the other side of that, well, we have compounding pharmacies that for them it makes sense. What if we could just make these compounds and then sell them directly to patients? We make a small margin and we sell it. This makes sense for us. Well, they could do that starting in about 2014 whenever that legislation finished. All right.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“Back in the 1800s or early 1900s, if you ever needed a medication, you go see the pharmacist who had a shop down the road and he would actually make your medication in front of you. And he would do that custom for every single patient that came by. And it was only since the advent of modern factories that we had the modern pharmaceutical industry come about. But the truth is that, again, that's kind of paint by numbers. You're creating this one pill. It always seemed kind of crazy that the adult dose is one standardized dose for all adults. Like if you look at what your body composition is versus some of my patients, why is the dose in your blood pressure medicine the exact same? Like that doesn't seem to be quite right, but it is what it is. So when patients fall outside of that and they need custom medication, we still have those people who make custom formulations of medications. But instead of it being just your local pharmacist who's you going to mortar and pestle and is creating something in his back office, these are now large sophisticated industrial operations that can make custom formulations for patients.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“Completely agree with that. And they introduced a new set of regulations on top of compounding pharmacies, basically saying what you can and cannot make. And what they eventually said is, well, you can only make three things. You can make things that are in the USP United States Pharmacopoeia, okay, things that have been well described, already published, things that are already in drugs that are already on the market. Or three, things that are on a very specific list that we're going to give you, okay? And in that list, they actually included a lot of these very promising compounds that were stuck in drug development, you know, limbo.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“So that happens in 2013. At the same time, I believe it was around 2012, 2013, there was a terrible event that happened in New England where there was a compounding pharmacy that was not doing the right thing, and they ended up having a bunch of contaminated specimens that caused a fungal meningitis. A bunch of patients got really sick. It was a huge scandal. And all of a sudden, the FDA stepped in and said, hey, historically, all right, states have been allowed to regulate compounding pharmacies themselves, but we need some federal oversight here because this is not acceptable.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“So, this is really interesting. In 2013, there was actually a court case in the United States. It was called Myriad Genetics Case. This was the company that actually patented the Broca 1 and BRACA2 genes. They discovered the genes that caused breast cancer. This was mind-blowing. They identified the specific genes that would predispose patients to developing both breast, ovarian, and since we've learned also prostate cancer. It was a fantastic discovery, but they patented it. And they said, we now own this intellectual property. Everyone else said, no, no, no, that's the human body. You can't patent that. And the Supreme Court actually sided with the argument saying that if something is natural, it's found within us. I can't patent your muscle cells, right? Which is a wonderful thing. But the unintentioned byproduct of that is all of a sudden, pharma had no incentive whatsoever to pursue really promising compounds that they could not monetize.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“Is so incredibly well tolerated. So just giving you an example of this is a compound that can have profound healing effects, at least in our animal models that we've seen so far. But so far, we haven't seen any precipitous negative effects in human patients when taking this, okay? But we need more data.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“Transsected, so they've cut across the Achilles tendon. So not just a small injury that you or I might experience in the gym where we pull it or strain it, but actually surgically cut the Achilles tendon and then they administer it to rats and they are healing spontaneously with administration of BPC-157. If you have an Achilles tendon injury and you're a rat, BPC-157 is one of the best things that you can ever have. Now, that is not a one-to-one translation to what we might see in humans. But as we talked about earlier with our point on safety, when they were studying BPC-157, we tried to look for something called the LD1 or the LD50. How much can I give this to someone until 50% of the population that receives that dose doesn't do well or dies? That's called the LD50 dose. We have yet to figure out what the LD1 dose is for this, which is the amount that it would take to hurt even 1% of the population because it”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“Because BPC 157 is a synthetic version of a naturally found peptide in the gut. But what this actually does is it enhances blood vessel growth in areas of injury. And it kind of makes sense because if you think about it, our gut, our stomach is really just this. Of acid that sits inside of our abdomen. And yet somehow you and I are here talking to each other and our bodies aren't eating themselves. Well, how does that work? Well, it's because we've developed a lot of really robust systems to encourage healing of the gastric lining. And so the idea is, well, if this is one of the compounds that can help do that, it's been proven in multiple animal models. For example, they have completely transected the Achilles tendon in rats.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“So, a good way to think about it is this. If you've got a hammer, right, which is what a lot of small molecules are, like you can do a lot with that, right? Like you could hammer in a nail, but if you try to use that hammer when you're trying to put in a screw or you're trying to put together, you know, a table that you got from IKEA, it may not always end the way that you want to. And that's the problem that we have with a lot of small molecules. It's not that they don't do what we want them to. They do a lot of other things while they're at that job that can have significant negative side effects, which is why a lot of these small molecules actually don't make it all the way through the FDA approval process because we find something, it does what we want to do. It has significant safety concerns down the line. What we see with peptides, for example, I've got in my hand right now a little vial labeled, you know, BPC-157, this is probably one of the most popular peptides that we're talking about right now.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“The best way to think about it is my son loves Legos, which is why I'm glad that we have these here, but he can take the same set of Legos and he can build a rocket ship. And then just a few minutes later, he can build a pirate ship. And then he builds a race car. And he's using the same Legos, but he's creating very, very different things that all do very, very different things. And so peptides have become incredibly popular because, yes, we have some really fascinating peptides that can help with anti-aging, with healing, and with tissue repair. We're going to talk about some of those, hopefully, but they can do so much more than that. The first peptide that was actually isolated and used in medicine was insulin back in 1921. And then all the way in 1985 in the world of urology, which is where I was trained, we had loop relied, which is a different peptide that, again, also a peptide like insulin, but instead of having wide ranging metabolic effects, it had an endocrine effect. It was designed to shut down.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“Peptides are a structural class of medications. The best way to think about peptides is that just like we have small molecules, which are drugs that are very small taken in a pill and have a wide-ranging effect throughout the body, peptides are derived from little pieces of amino acids, which think of them as the Legos that make up the human body, the Legos that make up proteins. These are fragments of proteins that are designed to specifically target certain receptors and affect cells in a very targeted fashion. Or a best way to think about it is a very specific targeted key to unlock a very specific lock. So instead of a small molecule that may have a wide ranging effect throughout the body, peptides are much, much more focused.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, this is unfortunately our future if we're not careful. So, what we've got here is representing the fertility trajectory for young men. And I'm so scared.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“Oh my gosh. There's meddling blue where people take it and they think it's going to make him live forever. Don't take this. It literally will stay in your nails blue and your hair blue. These two here stimulates building muscle. This one can aid with healing after an injury. And then is this, this, this, this.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“Let's do it. So, this is probably the most well known peptide for skin complexion, and it improves quality of hair and nails. And then epithalon is maybe, maybe not going to be the fountain of youth, but I'm very skeptical as far as that goes. Next, we've got this. And if you injected that at night, it would improve your quality of your sleep. Next, Melanitan too. And this will actually end up giving you a deep tan in response to just a little bit of UB sun exposure. It'll also give you some of the most impressive erections you've ever had in your life, so be warned.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“From the FDA, saying that in July they are going to consider legalize it, seven peptides. And by Pharma's estimate, it might be the most dangerous thing to their entire business model.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT
“This may be the most controversial thing we have on this table. This is a peptide that absolutely torches belly fat at a disproportionate rate. And what we found is not only do patients lose an incredible amount of weight, but they also get the best improvements we've ever seen in their liver health. It's absolutely wild. And I think this is going to be a trillion dollar drug when it comes out.”
2026-04-20 · The Diary of a CEO · The Peptide Expert: Big Pharma Are Hiding This Powerful Peptide From You! - Dr. Alex Tatem · IDENTIFIED FROM THE TRANSCRIPT