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Dr. Martin Picard

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2026-07-02
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  1. Where do they go? The best place for people to go is a website martinpicard.energy. And then from this website, you'll see information about the book. You'll see information about the research, core energetic principles that cover what we've covered today. They're little animations, and there's information about the institute

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  2. The things that really mattered were like sharper, right? And all of this other shit, like these obligations and these things that I had said yes to or like, you know, the contrast was so much sharper. And this lesson, I took this as a lesson slowing down, I think has allowed me to be a better listener, to be a better, you know, more compassionate father and scientist. I think it's changed me. And I don't know that I would have learned that lesson. We are this energetic process that's shaped by the sum of our experiences and the people we meet, like I'll never be the same after today from having sat with you at this table and you opening the door. Just to scientific inquiry, but to human experience. We change all the time. We transform. And what shapes us is those kind of energetic interactions. Everything we go through

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  3. And grew a team and moving fast is kind of something that's like a personality trait that I do. And I think sometimes it's served me. It's allowed me to do some things that would not have been possible otherwise. But at other times, I think it's hurt me. And it's like this drive, this inner drive of like things must happen now, must move fast. I think I've heard other people around and has impaired my ability to be an effective leader because then maybe I lack sensitivity to other people who don't move at my pace to slowing down really kind of hit home. Things were like clear. It was like looking at a canvas and There was more contrast

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  4. I was like, but how could there be something to learn from some things so terrible? And I had to sit with this. And two days later, after the baby had gone and Nirosha and I had sat in the shower and cried. The smell was horrible, and just death. Like death was around us, around me, and I felt angry and I felt sad. And I just sat down and wrote. And that's my way now of letting things flow. Different people have different ways. And I was writing about my experience and why now. And I ask, what is there to learn from this? And a very clear answer came up. Slowing down. And that hit really hard because throughout my whole life, I've moved pretty quickly through life. I had a very short PhD and then I became a professor very quickly.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  5. So we ended up having a miscarriage, and Narosha didn't want to go to the hospital, so we did this at home. And it was terrible. It was really, really sad, really, you know, gut-wrenching. So we were both devastated when new life left us. And then I had this moment of like, why me? Why the fuck this has happened to me? I think I'm a good person. I'm doing my best to bring good in the world. I try to be a good partner, a good leader. I try to, yeah, why is this happening to me? So this was like this victim mentality mindset. And I've learned through my 40 or so years that I think a useful stance to take in life is to assume that there's something to learn from everything you go through. I don't know this for sure. It's not a scientific fact. It's more of an experience turned into kind of a way of living, more of a belief.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  6. Felt like this sinking feeling. About a year ago, my fianc ⁇ and I were expecting a baby. And we were about three months into the pregnancy. And it was great. We were excited. We were calling this new life, new life. And we talked affectionately about it. And we said, you know, when new life comes, this and we both have a child And she was in Canada. She came back. And then that evening in bed, she had this crazy pain that started. And we were about super scared. There was a bit of bleeding. And then contraction started to come really fast, not supposed to happen at three months. And I was like, oh, maybe this is just like a bump in the road and things are going to be fine

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  7. The content of her lives is aligned with who we are as individuals. And that requires that we feel into this movement and into our sensations and into the experiences we have. So that's the barometer that really guides us through life, like a GPS, an energetic GPS.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  8. Really, you know, we make how we feel. Like you wake up in the morning and either you feel great and you can change things or you wake up and you don't want to be here. That's an experience. And before you get there, you know, on the dark side, there's all of these decision points that we face and the power of discernment, right? And what we talked about with Steve Jobs, like this is the way. And then you feel strong about this discerning what's right for you, what's not right for you, what's the right direction is at the right time or not. Those are decisions we make, you know, with our guts. And there are many people who swear that this is the only way they make decisions. And if they make decisions rationally that ends up biting them in the butt. Because I think this thing and this energetic system is the most sensitive instrument that we have to know whether

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  9. So our team is working on it, and so we're building a platform, a technology platform, that would allow people to This new relationship is this sucking away your energy, or is this giving you energy? This new job, this new direction in life, there's so much. I mean, all of the important decisions we make.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  10. If you're not trained, right, like you're a regular guy, I'm not trained now. I run for like 20 minutes every other day. That's my routine. That's what I have enough time to do and I feel like it moves energy through my body in the right way. But if I go and I try to run a marathon, I'm going to injure myself. I'm going to hurt myself. So that would be too much for me. And so. I think that comes back to the point of feeling into your energy. We call this mitoception, right? Feeling into your mitochondria and what's sustainable. So I think there's an individualized stance that we need to take towards this.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  11. Yeah. I think the key principle here is anything that will make you breathe harder. Means that your mitochondria are working harder.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  12. People who do the best, like their mitochondria don't work the way they should, but they're able to find something that they love. They're able to find an expression for themselves and they're to have supportive family almost a universal theme for people to do well is they have a supportive environment and cultivating this is so precious and that brings us back maybe to social connections. You energetic process, me, energetic process, when we interact through sounds and physically shaking hands. And I feel your energy. I feel your excitement. You feel mine. And then we might vibe and resonate. And then maybe you find someone and you feel love for that person. I think love is the experience of resonance. And when you feel that with someone, it feels so special.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  13. I've seen this in patients with mitochondrial diseases as well. You know, these people are diagnosed with the genetically defined mitochondrial disease. Their mitochondria can flow energy properly. So every day they live, probably with this kind of discomfort of holding your breath for too long. Everything's difficult about life. Many of them lose hope. And when you see them losing hope, they start to go downhill physically and many of them die very early.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  14. Very often there's a trigger. There's sometimes a lingering kind of condition and then sometimes there's an acute trigger and the body is never able to fully recover. So what do we take from that story of a summer fling?

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  15. I'm not saying what ended up happening is she said my chronic fatigue kind of lifted and I didn't have to do anything. And then after that summer, she never had chronic fatigue again. And she kind of reintegrated the normal life. I don't know what the lesson is here. I don't know if there's a generalizable principle, but there's a lot of those stories where people end up in a really dark place in their life. And either they're diagnosed with the mental illness or with chronic fatigues syndrome or with kind of a somato, psychosomatic label or whatever that is, there's always kind of precipitating conditions. Sometimes it's in response to medical interventions like immunization. Sometimes it's in response to an infection or like a parasite.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  16. Which is, I think, a common story. And she was in bed like multiple hours every day and struggling to go get groceries. And everything was a drag about life. And then one summer, this guy from Hawaii, which was a friend of a friend, came over for the summer just for a little trip. And they had an affair. She had a boyfriend. And this was a long time that she had had a human connection like this.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  17. What do you work on? And what do you do? And so I tell her we work on mitochondria and psychobiology, mitochondrial psychobiology, how the mind and the body relate energetically. And she said, well, I have an interesting story for you. I said, okay. What's the story? So I used to have chronic fatigue syndrome. So I perked out. I was like, what happened? She was visibly an energetic person. She didn't look like she had an issue with energy. So she said she was in her 20s and she had like, she was debilitated. She couldn't work and, you know, she lived in this place and, you know, her life would kind of, you know, completely upside down because she didn't have energy to do anything.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  18. Sick, right? Or make you feel nauseous or tired other cytokines from the immune system when you're sick. When you're fighting an infection, do the same thing. The best study on mitochondria and chronic fatigue syndrome was published last year or the year before. And it showed that there is a deficiency in energy transformation in the mitochondria of the muscle. They took muscle biopsies, a little piece of muscle from the quad, from the thigh. And then they looked at how well can the mitochondria in the muscle of people with chronic fatigue syndrome flow energy. And what they found is the capacity is much lower. If the mitochondria can't flux energy properly, you should feel like you don't have the capacity to push, right? To exercise. So why is that? Why do those people have you lower mitochondrial energy transformation capacity? We don't know. There's so many stories, and I've been curious and interested about this. And I remember this family friend who came for dinner one night, and she was asking me.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  19. Feeling low energy. So there's a disconnect here, and MECFS, chronic fatigue, long COVID, these people have been a little bit ostracized from the medical community because doctors are really stuck. They have these patients, which are really difficult patients to deal with. First, they don't know what's wrong with them. And second, they don't have tools to help them get better. And then the classical thing is, well, exercise, but then many of these people, when they exercise, they actually get worse. And there's some studies that show increase inflammation. So those signals of energy resistance increase energy friction in the body go up after exercise in a normal person. And these people with chronic fatigue, it seems like they can skyrocket. And then that leads to this post-exertional malaise, right? We talked earlier about how the marker of energetic stress GDF-15 can go to the brain and make you feel.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  20. In the US, there's an estimated like three to five million people who have either myalgic encephalomyitis, chronic fatigue syndrome, MECFS, or long COVID version of this. In the UK, it's somewhere between like two and three million, I think. And then worldwide, there's 20, 24 million people have these syndromes, right?

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  21. And that's really problematic. Like all of the health recommendations we have and the way drugs get approved and the way we determine whether a drug is useful or not for disease X or Y is by comparing groups. And whenever you peel the surface of a clinical study of an RCT, you find some people are amazing responders and they're cured. They don't have symptoms. And then some people don't respond. These are called non-responders. And then some people get worse.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  22. And you say, What's the average depression or anxiety symptoms in this 500 people? Then you average these people together and then you group them, and then you compare means.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  23. People notice they have more energy. The ketogenic diet does not work for everyone. We don't know why. And the same way that we're all different, we all respond differently to even medications that are supposed to work the same for everyone. We have a science of averages. Like the science that we use to get knowledge, to inform our lives is almost entirely a science of averages, meaning like all of the studies we do, like the highest gold standard studies we consider to be RCTs, randomized controlled trials, these RCTs, if you run an RCT what you do is you take, let's say, a thousand people, then you randomize half 500 into this group, normal diet, and then 500 into ketogenic diet. And then you say, great, now let's look at their depressive symptoms, right? Or their anxiety symptoms. And then you have them on the diet for two months. And then after you assess, and then you compare the groups, right? You lump 500 human beings together.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  24. We've covered that ground. Yeah, life changes, you know, changing your life circumstances, that's really hard to do exercising seems to help a lot of people, but a lot of people don't feel they have the capacity to exercise. And ketones seem to be a life-saving for some people. Going on a ketogenic diet, and I've met now dozens of individuals whose lives were crushed by schizoaffective disorder, bipolar disorder, major depressive disorder. And they were treatment resistant, right? Meaning like the pharmacotherapy, the drugs that they were given were not helping in some cases, were making things worse with difficult side effects. And then they changed their diet, cutting all sugars and they went on a ketogenic diet, medical ketogenic therapy. And then they started to monitor ketones. And many people reported that this was life-changing. Like first, the first thing they mentioned.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  25. Directly measuring energy resistance in the brain from a McLean in Harvard, and then lactate tends to be elevated and people with mental illness. And this marker, GDF-15, also is elevated in mental illness.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  26. Kind of doing something to neurochemistry. What you're doing is you're injecting the human body with a signal that the mitochondria can't keep up with energy flow. You're tricking the body into thinking that energy resistance has just been jacked up to very high levels. This feels like anxiety and people with traumatic memories, like post-traumatic stress disorder, PTSD, the simple injection of an energetic stress signal of lactate in the blood can reawaken traumatic memories. So there's this emerging notion in psychiatry and metabolic psychiatry where people understand mental illnesses as energetic disorders of the brain. And what I think is happening in those kind of chronic state of ill-being, right, where people don't feel themselves. They don't feel well. The hypervigilance, anxiety, it's quite likely at this point, I think, that part of that is driven by energy not flowing properly. And then the body just lives at high energy resistance all the time.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  27. This horrible feeling, like you wake up in the morning and you have this like Trace of running out of energy, right? Running out of oxygen. I think that's what some mental illnesses feel like. And there's very interesting data showing that if you inject people with a signal of energetic stress, lactate, you can trigger a panic attack. You're not messing with the brain there. You're not like, you know.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  28. Panicking is kind of a. We're imposing now an experience onto a biological process. But you have the electrons that are flowing through mitochondria all the time. They're flowing onto oxygen, right? From food to oxygen. And they're just nice freely floating. That feels great. Or it feels like just normal life. And then all of a sudden, there's no more oxygen. So the electron, oh, I have nowhere to go. That feels terrible. The electrons can't flow. So they start to backflow. That is what causes oxidative stress. That's why the heart gets damaged during a heart attack, right? Because the electrons can't flow to oxygen because of this little clot. And for some reason that we don't really understand, this feels extremely aversive. And anyone who's listening to this can try on their own, hold their breath for as long as possible. It feels horrible. And now imagine living your life with just like 5%, 10%.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  29. Well, I think that, yes. So the subjective experience, right? What you describe there is an experience of energy starting to stall. Because if there's no oxygen in your mitochondria, the electrons like, where do I go? And then there's extreme level of resistance. The most extreme case of energy resistance, I think, that most people will be familiar with is like a heart attack. My dad had a heart attack a few years ago, and he woke up during the night with this terrible contraction, like a pressure in the chest. And he said it was like 400 pounds. What's happening? Like, what is that pain? The source of that pain really is blood flow can no longer bring oxygen to mitochondria in the heart.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  30. Starming fair, yeah, you know, running out of air and like drowning is one of the most horrible, like aversive experience that I think we evolve to dislike, right? So what was happening there in our bodies as we were doing this is Oxygen is being consumed by mitochondria continuously, right? Every millisecond mitochondria consume oxygen, and now you're not bringing oxygen through your breath. And then they produce CO2, carbon dioxide, right? So mitochondria are burning the oxygen a little bit by a little bit, and then they're producing carbon dioxide, CO2. And we evolved to feel those signals very, very sensitively.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  31. And we'll use the breath. So you can start by just feeling your body, you can feel kind of gravity pulling your body down into the chair. We'll take a little breath in. and then Holder For as long as you can. And just pay attention to the sensations that are emerging in your body. Whether it's in your belly and your chest and your neck and your head And the longer you wait, the more intense those sensations are. You can hold for as long as you want, then when you can't and just deep breath. Deep breath. That

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  32. There is for the same reason you close your eyes earlier when I ask you to kind of feel inside. This is a good analogy for, I think, what it means to kind of listen to her energy. And maybe we could do a little exercise if you're interested. Sure. So we'll do a little exercise. You can close your eyes if you want.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  33. This bell-shaped relationship is something we see in many domains of biology and physiology, same as workout, exercising. Like most people know if you do a workout that's like half an hour, an hour, two hours, if you're an athlete and you're like really well conditioned, it's fine. And then you recover for 23 hours after your one hour workout. And that's great. It actually makes you more efficient. It gives you the impression you have more energy, which is really energy flowing more efficiently. But if you work out for eight hours. That's not good, right? So too much, you crash, not enough, you're not at your optimal. So there's, where is the optimal state? And biology and the whole mind, body unit has kind of worked out through evolution and through your life and development to find this sweet spot.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  34. Is affecting my metabolism all the time we respond to each other energetically, metabolically. I think it supports that idea that you're in an energetic process and you're influenced by other forms of energy, even if you don't see it.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  35. Through the mouth. You can measure oxygen coming in and CO2 coming out, which is coming from mitochondria. So you can measure the energy metabolism, which is really the mitochondrial metabolism as people are doing this. And what they found is that people who had red light on their back, their metabolism was actually a little higher. So the electrons, the flow of energy was increased with the red light. And they think that might be why the glucose didn't spike as much because the electrons that came into the blood were able to flow through the mitochondria. So this points to some regulation of energy regulation inside the mitochondria that I don't fully understand, but I think there's something promising here. And it certainly supports the idea that energy modalities outside of our cells, light or electromagnetic fields, other human beings that are you energetic process.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  36. I don't know if there are studies that show too much red light is bad for you, but phototoxicity. On blood glucose regulation, and I know you've talked about blood glucose on other episodes. How much glucose in the blood is really important because it causes this energy resistance, energy friction in all of your cells, especially the brain perhaps. So when you eat a bunch of sugar or you eat a meal with carbohydrates, blood glucose typically spikes. If you get stressed out, just psychological stress will increase blood glucose. So those glucose spikes can increase energy resistance and then start to cause damage, accelerate aging, and so on. So what the body does in the normal healthy organism is able to regulate blood glucose. So if you eat a big meal, there's enough insulin that's released and then the glucose can come into cells and to the muscles and to the fat, and then you preserve what's called normal glycemia, normal blood glucose. It turns out if you shine a red light on the back of people as they ingest a big bunch of glucose, the spike in glucose is not as high. And what they did in that study that was interesting is they measured mitochondrial metals.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  37. I think that in general, that's why I kind of veer away from supplements because the organism is this beautiful dynamic equilibrium of everything energetically dancing with each other where you have the mitochondria that transform energy and then genes are expressed and then this other cell is doing this, this cell is doing this and there's this beautiful balance and when the system is out of balance now there are signals like inflammation, right? Signals of this imbalance out of an energetic level and then that turns into molecular level and then the system tries to come back into balance, right?

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  38. If you're deficient in that way, that might be good. That might also offset the natural order that your body has created.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  39. Someone was just telling me their dad is part of a study now. He puts a helmet with red light, you know, every day because he has a pre-dementia. By doing this, the idea is light is energy. Energy is not a thing, but it's the potential for change. It's the capacity to change something. Red light like this, especially the red, the infrared that you don't see with your eye, can penetrate tissue. It can go through your hair, through your skull, and then into your brain. And then there, it seems to do something and change metabolism. So how is it doing this? The best hypothesis we have is that for light to do something in biology, there needs to be something biology that resonates with it, right? That can offer the right amount of resistance to the photons of red light photons hit. And then there's transformation of energy. That receptor, the antenna, the cell leader antenna for red light seems to be mitochondria. So there's something in the mitochondria where the electrons flow and then boom, they meet with oxygen to become metabolic water. That is called cytochrome C oxidase.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  40. Interestingly, the red light therapy is a pretty big thing now. There are hundreds of different devices, helmets, hairbrush, band

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  41. Yes. So we're not in the optimal environment. When you're in that kind of environment, so I think there are, and there's good research showing if you put a plant in a hospital room, patients recover faster. There's been studies looking at windows with natural light and you see nature if you're in a hospital, for example. People recover better and there's good data on nature exposure. Is it more better oxygen? A little tiny bit more oxygen if you're in a forest. Is it like the phytochemicals, the things that are produced by the plants? We don't really know what it is. Is it just seeing green, seeing something that hears it sounds and looks like what you evolved to be around? So we don't really know, but we know exposure to nature kind of helps calm the body and somehow improve recovery.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  42. It means recognizing that I am the energy that's flowing through this thing. And this thing is nature. Like we are a piece of nature, something that's true across the animal kingdom and the living kingdom is things heal. And we don't think about this in biomedicine. We think about diseases. We study when things go wrong and we try to understand the molecular features of diseases. There's not really a science of the healing process. But the basis of health, it's clear, you need to heal continuously, heal, you know, repair the DNA that's damaged, repair the mitochondria that are getting old, you get rid of them, you make new ones, like preserving the wholeness of the system to heal means to become whole again

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  43. And so the term mitochondrial dysfunction is, I think, a little misleading. There was a lot of hyperbut NAD. There was a lot of hype about coenzyme. There was a lot of hype about all sorts of things, anti-inflammatory, you know, berries and tixidents was a big thing 10, 20 years ago. Turns out not to be so useful actually impairs normal adaptation and signaling if you eat too many antioxidants. So then A feels like the next fad. Maybe it's real. I think the science is fairly compelling, but I trust the wisdom of my body and my mitochondria more than I trust the pharma company that's trying to make and sell this.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  44. I'm skeptical of this. There's always kind of a new supplement that does amazing things, especially if it cures mitochondrial dysfunction. Mitochondria have dozens of functions.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  45. Your Lithin A is a new compound that seems to stimulate the degradation of bad mitochondria. We talked about autophytophagy earlier. So a cell that has a thousand mitochondria, there are always some that are getting a little old and then eventually they're degraded, especially if you fast, right? If the cell is a little starved, it's going to degrade the ones that are least functional and there's kind of a whole selection process that happens inside the cell to know which mitochondria are bad, which ones are good. But the bad mitochondria get targeted and then they get degraded if you're fasting or if you're pushing the system like drink exercise. What urolitin A seems to do is to kind of accelerate this process, right? So it accelerates the degradation of the bad mitochondria, the mitophagy. So the cell has to make more of the good ones.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  46. Yes, I think there's oral supplements that are precursors to NAD. If you eat NAD directly, the bioavailability it's called, it doesn't get into your cells very well. You can inject infuse IV intravenously NAD+ directly, and then that gets to your cells better. That's not an approved or kind of recommended medical intervention. But I've seen people with mitochondrial disease saying that it helps them and normal healthy people as well who feel more energy.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  47. Yep. And most people are not deficient of NAD. So giving more to the system might not help. But for reasons I don't really understand, it seems like it helps some people and it makes people feel more energetic.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  48. In some cases, I don't really know how metalene blue does everything it's supposed to be doing. Biologically, metalene blue seems to be able to give electrons to the mitochondria. So maybe there's something there that methylene blue kind of kind of relieve energy resistance in the mitochondria. NAD plus is probably the best supported intervention to reduce inflammation. Also, it's an electron carrier. So I take electrons from food and then gives them to the electron transport chain, so the mitochondria can flow those electrons with low resistance. So if you're depleted of NAD, that's going to cause increased resistance for electrons to flow through this metabolic circuit.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  49. I think there are shortcuts to some States, I lean away from them because I think once we start to think that there's a magic pill to solve a complex issue, to solve the way that you're feeling becomes like the, oh, there's a magic pill for this. And then you don't need to bring awareness to what you are.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT

  50. I think part of it is yes, living a life that is more aligned with the way we evolved, which is connecting to other human beings and not eating too much. And I think that's one piece. But that's like everyone knows this. Why aren't we doing it? And I think part of the reason is because we have this kind of misconception of ourselves as a molecular machine. And it's like need to maintain your car. If I'm like a machine, if I'm like a car, then I'm just going to put more fuel in and I should feel better. And then you do it, then you eat more and then you don't feel better. And that's, I think, extremely disempowering. People want to be empowered and people want to have knowledge, but they want to know what to do so they can be the best version of themselves, so they can flourish.

    2026-07-02 · The Diary of a CEO · Why You’re Tired: How Stress Drains Your Cells - Dr. Martin Picard · IDENTIFIED FROM THE TRANSCRIPT