YouSaid · the spoken record

Manolis Kellis

lines on the record: 152
first: 2020-09-12
most recent: 2020-09-12
sittings or episodes: 1
sources: podcast

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“30 trillion Every one of them two meters worth of DNA. So, all of that is compacted through the epigenome. The epigenome basically has the ability to compact this massive amount. into just a nuclei of one human body and the vast majority of human body is not even these nuclei. And that's sort of the structural part. So that's the boring part. That's the structural part. The functional part is way more interesting. So functionally, what the human epigenome allows you to do is basically control the activity patterns of thousands of genes. So 20,000 genes in your human body, every one of your cells only needs a few thousand of those, but a different few thousand of those. And the way that your cells remember what their identity is, is basically driven by the epigenome. So the epigenome is both structural in sort of making this dramatic compaction. And it's also functional in being able to actually control the activity patterns of all your cells.”
2020-09-12 · Lex Fridman Podcast · #123 – Manolis Kellis: Origin of Life, Humans, Ideas, Suffering, and Happiness · IDENTIFIED FROM THE TRANSCRIPT · source
“Get me started. So, first of all, as an engineering feat, the human epigenome manages the most compact, the most incredible compaction you could imagine. So every single one of your cells contains two meters worth of DNA. And this is compacted in a radius which is one thousandth of a millimeter. That's six orders of magnitude. To give you a sense of scale, it's as if a string as tall as the Bourges al Khalifa. Is about a kilometer tall, was compacted into a tiny little ball the size of a millimeter. And if you put it all together, if you stretch the trillions of cells that we have, we have about 30 trillion cells in your body. If you stretch the DNA, the two meters worth of DNA in every one of your trillion cells, You would basically reach all the way to Jupiter Hundred times”
2020-09-12 · Lex Fridman Podcast · #123 – Manolis Kellis: Origin of Life, Humans, Ideas, Suffering, and Happiness · IDENTIFIED FROM THE TRANSCRIPT · source