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Max Lugavere

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2023-02-20
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2023-02-20
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  1. Yeah, it's a big problem, whether it's constant climate control. So, I mean, just like so few of us are willing at any point to venture out of our comfort zone and to be uncomfortable. And I think our biology suffers as a result. This isn't just, you know, this is like there's actual now basic science underpinning this concept that when we apply stress to the body or even via the foods that we consume this like mild hormetic stress that we get that we get from certain compounds, whether those compounds are in turmeric or kale or broccoli or what have you, that

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  2. And so we know that Sonas are essentially the best workout that you can have while sitting absolutely still. You're also purging toxins through your sweat, compounds that aren't as effectively excreted via stool and urine. So it's like there's a lot of good stuff going for saunas and of course more research needs to be done. But all indicators seem to point towards a positive health effect.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  3. All cause mortality. Now, just to be clear, these are still correlational studies, but mechanistically, there's plausibility there. And that is, you know, we know that when you use a sauna, it does have a positive impact on your blood pressure. We know that it can reduce inflammation. We know that it gets your heart rate up. I mean, I know this. Whenever I use a sauna, I put my finger on the artery in my wrist and I can see that I'm getting like almost like a mild aerobic workout.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  4. Or taking a sauna as the Finns say probably has access to a gym, probably is going to the spa regularly, probably is like putting a great deal of attention on their own physical health, right? But in Finland, that's not the case. People aren't doing saunas as like a health modality. They do it because they love it, because it's a self to the, you know, to the cold temperatures there. And it's just a part of like the normal routine. And so what they're finding is that just using a sauna two to three times a week is associated with a 22% risk reduction for dementia and using it four to seven times per week is associated with a 65 reduced risk for the development of dementia. So that's like a dose response. The more you use it, the more robust the health effect seems to be. And it's not just for dementia. They've seen a reduced risk for hypertension, which we know is really important. We know that the brain, that blood pressure is really important from the standpoint of brain health. So you want to make sure that your blood pressure is healthy. Also,

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  5. Of eastern Finland, which is a great place for this research to be done because saunas in Finland are like taking a shower. So you could say if that study were done, if those studies were being done here in the United States, you could easily write them off to healthy user bias because somebody who's regularly saunaing.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  6. Low to moderate doses of a stressor actually are as opposed to being rather than being harmful to the body actually elicit an adaptive response that makes the body come out on the other side stronger and more resilient. And so that is essentially the mechanism, the proposed mechanism underlying why it seems that saunas are beneficial to our health, but also exercise and also cold water immersion and also intermittent fasting and also even some of these like plant compounds. We consume myriad compounds and plants that if we were to consume big doses might actually have a toxic effect, but in small doses actually are thought to benefit our health via this same hormetic pathway. But yeah, sauna use, a lot of the research is coming out of the universe.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  7. Yeah, so norepinephrine is actually produced in a part of the brain called the locus ceruleus, which is like one of the first structures to become damaged in Alzheimer's disease. And so that sort of like the hub of norepinephrine release. And we see that when we apply physical stress to the body of which saunas are one type, that there is an upregulation of norepinephrine release. And yeah, so that might in a way sort of help, you know, prime the body to adapt and become more resilient. Because that's essentially what stressors do to the body. That's the whole concept underlying hormesis. That hormesis, which is like low doses of

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  8. Which most people are, and you're seeing, and your mood is not where you think it ought to be. I absolutely think a first line of defense should be, you know, adopting more of these or integrating rather more of these whole foods and cutting out the ultra-processed foods. And then, of course, I mean, like sort of, you can't really talk about lifestyle and mental health without mentioning exercise. Exercise is, you know, I mean, there's like a bounty of evidence at this point showing us that exercise is like literally medicine for the brain.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  9. Published the first ever randomized control trial where they used a dietary intervention to treat depression, major depression. So it was called the Smiles trial. And anybody can look this up, but they used a Whole Foods diet, Mediterranean-style diet that was inclusive of red meat, fish, dark leafy greens, berries, olive oil, eggs, things like that. And they found that in the patients with major depression compared to controls that were treated with the standard of care, they saw something like a threefold increase in remission from the dietary intervention. Now, these were patients, obviously, that, or I guess not obviously, but they were patients that were on a junk food diet. So, if you're on a junk food diet

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  10. Mediterranean cell, yeah, I don't care what proportion of animal products or plant products you have, although I think including both to some degree is probably better than not Provided you're not allergic or have any specific sensitivity, but they're now using diet as an intervention to improve symptoms. So the same Food and Mood Center, which is actually one of the institutions that's really kind of championing this field of nutritional psychiatry.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  11. So, I think that's I think animal products super important. Eggs, you know, a rich source of choline, fatty fish, but generally like whole foods. I think whole foods, a whole food dietary pattern. So minimally processed, again, like the foods that you find around the perimeter of the supermarket that you cook for yourself

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  12. And they didn't see that association for other animal proteins. So they didn't see it for chicken, pork. And they also saw an increased risk when people, when women ate much more than that three to four serving recommendation. And when you actually look into what red meat contains in it, it contains a lot of nutrients that we know directly support the brain, whether it's zinc or vitamin B12. You could look at a food like beef liver, which is one of the best sources of folate. We know that low folate consumption is associated with depression.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  13. By the latest data that I've seen, at least a doubling of risk. Now, the question that always arises there is, is the vegan dietary pattern causing the depression, or are people who are more prone to depression gravitating to the vegan diet? I think it's probably bidirectional because we know that animal products in particular contain nutrients that seem to be very supportive of good mental health. There was one study out of Deacon University's food and mood center.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  14. And that's just shocking to me. The first is unintentional injury. So it's like drunk driving and just doing stupid things. But yeah, when it comes to mental health, I mean, our mental status is highly responsive to the outside to our environment. And our environment includes how we're living our lives, the people that we surround ourselves with on a daily basis, and indeed the foods that we're eating. When it comes to mental health, there are a number of really interesting observational studies that show us that vegan and vegetarian diets, but I think particularly vegan diets put people at increased risk for depression.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  15. Oh man. Yeah, mental health is so I learned this recently, which is just shocking that the number two cause of death for people between the ages of fifteen and thirty five in that sort of ballpark demographic, the second cause of death is suicide

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  16. And I think that's just crucially important. So, what that implies is as we age, you know, that we continue to be mobile and to move about the world and to be free of depression and we stay connected in our communities. And I think eating a healthy diet, exercising, staying socially connected. I mean, averting loneliness, these are all crucially, crucially important. Yeah, unfortunately today, I think we tend to think only in terms of lifespan. I just want to live as long as possible. But today for many people, particularly in the Western world, It's, you know, it's like a double-edged sword because, yeah, you're living longer, but most people in elder age today are frail. They have chronic health conditions. And it's a big problem.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  17. Great question. Today we are living longer, right? Thanks to modern medical advances. Not all of us, my mom, you know, my mom didn't have a lengthy lifespan, but generally we're living longer, but we are also dying longer. And what I mean by that is that we're spending, our health spans are shrinking. So our lifespans are expanding, but we're actually spending more of our life, especially particularly in our latter years, sick, burdened with chronic disease and disability. And so I think it's really important that we not just have a lengthening of lifespan in our crosshairs, but that we also aspire to lengthen our health span. So we want to prevent chronic disease and disability to the best of our ability.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  18. Would get it from food. They would get it from fruits and vegetables and even animal products or a good source of hydration. So oftentimes when we think that we're hungry, we just need a little bit of hydration. So all those three factors, the protein, the fiber and the hydration are all severely lacking in Pringles and other ultra-processed foods, not to call it specifically Pring Um. Yeah, but these kinds of foods that we now consume to our detriment today in the 21st century would have potentially saved the life of a hunter-gatherer, one of our ancestors, back prior to the ubiquity of food stability. So, yeah, not to hate on your Pringles addiction.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  19. Yeah, it's good for weight loss to prioritize protein and fiber, dietary fiber. And then water. So water is the number one enemy of shelf stability. And so ultra-processed foods, they want long shelf lives. That's like key to a profitable ultra-processed food product, right? It can be shipped overseas. It can stay for months on the shelf. Very little waste. And so products like Pringles, devoid of what they're completely dehydrated, right? And water, sometimes when we're hungry, we're actually thirsty. It's just that those wires are getting sort of crossed and miscommunicated. But your average hunter-gatherer didn't have access to, you know, running water. They couldn't just pop into their local gas station and buy bottled water. Where did a hunter gatherer find water when it wasn't readily available?

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  20. Nutrients like vitamins A, E, D, and K, and various fat soluble plant compounds, but its carbohydrates and fat that are energy very easily stored by the body. We can easily store carbohydrates in our liver as sugar, glycogen, and in our musculature, and we can easily store fat in fat. So protein, very difficult to store. So that's the other, that's the first factor that makes a food satiating. Pringles are a low protein food. The second factor is fiber. Pringles are devoid of, largely devoid of fiber. Fiber slows, you know, like we saw in the Apple example. It slows the transit of food in the stomach. It makes us feel more satiated. It also absorbs water and it mechanically stretches out the stomach, which turns off certain hunger hormones like grelin, for example.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  21. And so too is fat. I mean, fat is energy as well. We have a minimal daily requirement for essential fats. And we see that higher fat can support energy. As I mentioned, you don't want to go low fat because fat supports hormone production. We see that people on low-fat diets tend to have lower testosterone. It also facilitates the absorption of very important fat-soluble.

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  22. It's the most satiating macronutrient and it is a really important macronutrient for nourishing our musculature. And ultimately us washing our hunger. When you eat more protein, you eat less carbs and fat. And carbs and fat are energy. Protein is, it's very difficult for your body to store protein. Your body doesn't want to store. There's so many uses for protein in your body, whether it's to create neurotransmitters or to rebuild your muscle tissue or your bones or ligaments. to create enzymes. I mean, protein, like protein has so many roles in the body carbs and fat for the most part are just energy. I mean, there's no such thing as an essential carbohydrate. That's not to say that carbohydrates are bad, by the way, because a lot of people will hear that and say, oh, I don't, I could get by on zero carbohydrates. Carbohydrates are important for optimizing hormones, for optimizing exercise performance, but there's no such thing as an essential carbohydrate. It's essentially...

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  23. Once you pop, you can't stop. That is a truism with scientific backing. We know that Pringles are ultra-processed. We know that they're minimally satiating. Are three characteristics that make a food satiating, and Pringles lack all of them. So one is protein. Protein is the most satiating of the macronutrients. So for anybody struggling with hunger, pangs, or whatever, prioritize protein in your diet, increase the amount of protein that you're consuming. For a person with healthy kidneys, there is absolutely nothing to worry about with regard to high protein consumption.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  24. Another one, the way that when I'm eating tortilla chips, while I'm chewing on one tortilla chip, I'm already Know lusting after the one that's in my hands, right? I'm not even like focused on the one that's in my mouth. And so

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  25. Five, six apples in one glass. But after eating a delicious, even the most delicious honey crisp apple, which I love, it's like one of my favorite foods, I've never felt the need to go and get it.

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  26. Fills you a bit more. Yeah, first of all, you're eating it, there's a speed at which you're eating it that's a lot slower than when you drink the fruit juice. So it takes a lot, you know, it allows your body or stomach to realize that it now has food in it to turn off some of those hunger signals like the hormone growing. You also, when you chew it, you leave large particles of the apple that might take an hour to fully digest. The food matrix has fiber in it, like the fiber from that apple. So it slows the transit of that sugar. It slows it. It blunts basically the blood sugar spike. You're also getting lots of water along with the sugar that you're consuming when you consume that apple. It's a lot different when you're just drinking juice. It's a lot easier to get the fruit sugar from, you know, if you're drinking apple juice, for example, you can easily drink the sugar of

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  27. I mean, you can squeeze the fruit sugar from five, six oranges in one glass of orange juice. I mean, think about it. The last time you like ate a whole apple. Did you feel afterwards that you wanted to go and eat another apple?

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  28. Sort of a proxy or surrogate, if you will, for ultra processed foods. Like ultra-processed foods are going to have those two compounds in them as opposed to fresh foods. The dose makes the poison. But yeah, I would recommend avoiding them because that study was like pretty... Pretty eye-opening. And the chronic consumption of those two compounds, I would say probably worth avoiding.

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  29. Yeah, yes, all dressings. What they've shown in animal models is that those substances degrade the mucosa, this like really important lining that separates the inner contents of our GI tract from our gut epithelial cells, which there's a chapter in genius foods that I'm very proud of on the gut microbiome, all the new science surrounding the gut microbiome and how the gut brain axis really in many ways influences not just brain function, but might have an effect on our predilection to disease. And so anything that inflames the gut, the gut isn't like Vegas. Like what happens in the gut doesn't necessarily stay in the gut. And so these two compounds were shown in animal models to have a profound inflammatory effect on the gut. I recommend looking out for them and avoiding them. Now they're also a

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  30. Yeah, so specifically in the book, we call out polysorbate 80 and carboxymethylcellulose, which are synthetic emulsifiers that are used to create pleasing mouthfeels in foods that combine hydrophilic and hydrophobic substances, so oil and water or fatty substances and more aqueous solution. And so the archetypes of those foods would be nut milks and ice creams. And what they've shown in animal models, to be clear,

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  31. And a highly nutritious part of a diet. It's actually like red meat and animal products in general. They tend to be our most nutrient-dense foods. There was a paper by Ty Beale, who's a nutrition researcher whose work I follow that found that if you looked at the top six or so most nutrient-dense foods available to us, they're all animal products, with the exception of maybe dark leafy greens, which are also very nutrient dense. So, yeah, I'm pretty unapologetic in my endorsement. Of animal products. Yeah.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  32. And I would never go so far as to say that I know what caused my mom's illness. Like, you know, I don't even know if it was her lack of consuming meat. I don't know. But it's clear that her low meat diet didn't protect her. And I'm pretty convinced at this point that some is certainly better than none. I don't advocate. I think some people think that I advocate for a high meat diet or even like a carnivore diet. I don't. I just, I really think it's an important part of a balanced diet.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  33. Know that people direly need iron deficiency anemia is a real global problem. One in four people globally are anemic and half of those cases are due to iron deficiency. And red meat is like the ultimate iron supplement. So, yeah, so I get passionate about this. I think in part because my mom was a vegetarian and there were many times as I was reading about all this stuff that I wanted to shake my mom and be like, you know, mom, you're letting your ideology impact your biology. You know, that's like not something that you want to happen

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  34. In like nutrition science is that if you look in the nutrition literature, you can find a study to back up anything that you want to say. I'm always hyper conscious of that. But that's certainly the case with meat because, you know, these observational studies, they just, they're so difficult to do. But now newer studies are showing us that when you control for these kinds of things like diet quality, that there's no association, that meat actually is a very nutritious food. And with the small slew of randomized control trials that we have with regard to red meat, we see no negative impact with regard to an actual real clinical outcome. And oftentimes we see benefit because it's a pristine, wonderful source of protein. It's a wonderful source of many micronutrients that we know are people tend to underconsume today. Nutrients of concern, so to speak, like zinc, vitamin B12, nutrients that we

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  35. Most people who consume red meat, yeah, they're eating it in the form of hot dogs and hamburgers and subway sandwiches with the fries, with the large Coke. So all that is to say is that it's very easy to find links. And that's why there is this funny...

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  36. And so, if you were to take a food like quinoa, for example, which, first of all, if you know how to pronounce quinoa, you're probably reading health blogs, right? You've probably listened to a health podcast or two, right? Consumption of quinoa is probably associated. I don't know if this study has been done, but I would bet, I would bet $500 today that consumption of quinoa is associated with robust health. Is it because the quinoa is so healthy, or is it because the person that's eating quinoa on a regular basis, that person's probably a pretty health conscious person? That person probably shops at Whole Foods. That person probably has a gym membership, you know, so that's healthy user bias right there. And so it works in the inverse sort of way with red meat. There are very few health-conscious. I mean, there are more now, but we're like sort of a niche, you know, like we're people on the paleo diet, so to speak.

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  37. People who eat more red meat, they tend to smoke more, they tend to be more sedentary, they tend to eat more fast food. Like most meat products consumed in this country are hamburgers. They're chicken nuggets, they're those kinds of foods, ultra-processed meat products. Conversely, if you look at the consumption of fresh fruits and vegetables, you see healthy user bias there too, favoring fresh fruits and vegetables. And that's, you know, it's pretty obvious to understand why. Most people today are like obese. They're consuming ultra processed foods day and night, fast food, shelf-stable convenience foods, the kinds of foods that foods in quotes that you would get from like a vending machine, for example. Those are the foods that are like the base of most people's food pyramids, so to speak.

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  38. Yeah, exactly. It's very easy to zoom out at the population level and to see links drawn between meat consumption and anything bad imaginable, right? Because most of the time, first of all, people who consume more meat, especially in this country, tend to be more sedentary and they tend to smoke more. They tend to, this is the whole concept of healthy user bias, which is so crucially important. You have to know if you intend to know anything about nutrition, you have to know about healthy user bias.

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  39. Yeah, I mean, it's dietary quality as a whole. There was a great study people can look up Maximova is the first author, I believe the year it was published was 2017 or 2018. They looked at all cause cancer and they found that when people were eating meat on a low quality diet, meaning meat in the context of fast food, right? That, yeah, there was an increased risk for cancer. But once diet quality was high, meaning that people were eating meat with fresh fruits and vegetables clearly a dietary pattern indicative of health consciousness, that that risk of cancer was completely abolished. So yeah, like, you know, early on in nutrition, I think it was, you know, with poor quality studies

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  40. Just over the past year, there have been a number of really important studies. Generally observational in nature, that's kind of one of the issues with nutrition science. It's really we have very few long-term randomized control trials to show us with certainty that these connections are causal. But the UK biobank study, which is a very large population, 500,000 people. Observational study found that A dose response, meaning the more I believe animal products were consumed, the lower the risk of dementia and Alzheimer's disease by a pretty significant margin. We see that red meat is not associated with the kinds of health problems that we've been told for decades

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  41. Yes But also now we're starting to see other forms of animal products like beef, chicken, dairy are associated with reduced risk of cognitive decline. We know that animal products are the richest source of choline, and we've seen that higher consumption of choline is associated with reducing.

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  42. That will try to censor you in talking about it now from the vegan camp, like the people who advocate for these plant-based diets because the ketogenic diet tends to be a diet that is inclusive of animal products in some iterations of it, it might even be in a high animal product diet, right? But they're just like against it because it includes animal products. talking about neurology and you're not also talking about the ketogenic diet, then you're doing a massive disservice to patients, I think, around the world.

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  43. Has gotten to a point of glucose intolerance. Yeah, being on a low carb diet might actually be a good therapeutic option. It's not fixing the issue, so to speak, but that's the same. I would say that's the analogy that I would draw to the ketogenic diet. It's a powerful therapeutic diet. And yeah, and we have to keep talking about it. There's a lot of people that will like.

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  44. So, this is like real science. There's now lots of evidence suggesting that ketogenic diets can be useful in the setting of various types of mental illness. So yeah, so I mean, I just think it's so crucially important to talk about. Now, does your average person need to be on a ketogenic diet for good health? No. Does the average person need to be on a ketogenic diet to prevent dementia? No. Similarly, it's the same thing with like for type 2 diabetes, which is now super common. It's not that sugar in the diet caused type 2 diabetes. It's the overconsumption of calories and the like, and it's the overfilling. I mean, that's a whole different rabbit hole, but the overfilling of a person's fat silos that then causes fat to accumulate in other organ tissues. And so carbohydrates are part of that problem, but does that mean that carbohydrates caused the issue? Not necessarily. However, for somebody with type 2 diabetes who essentially

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  45. Patients with Alzheimer's disease will actually start to develop a sweet tooth. And it's thought that that's in part the brain a response to the brain crying out for energy because its ability to create energy again from sugar is diminished by 50%. And so getting somebody with dementia to adhere to that diet, it's just really difficult to do. But if we can, if for example, the reader of my book were to one day have some kind of neurological condition and want to experiment with that, then that's a great thing. We also have various ketogenic therapies like whether it's MCT, oil, or powder or these exogenous ketone supplements. I know people tend to roll their eyes and think that these are like a fad now, but there's actually an FDA approved medical food on the market for the treatment of dementia called Axona, which is basically based on these medium change triglycerides.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  46. In the setting of Alzheimer's disease that have shown that at least in the short term, the ketogenic diet seems to provide some degree of symptom improvement, which I think is really important. Now, does that mean that the ketogenic diet is going to be right for every dementia patient? Certainly not, because it is an incredibly hard diet to adhere to. And particularly for somebody with dementia, I mean, putting somebody with dementia on any kind of diet outside of the diet that they're used to is virtually impossible, right? But in Alzheimer's disease specifically,

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  47. Years at this point. And that's because it's the only diet that changes the biochemistry of the brain. Like it does that in a very significant way. It provides an alternate fuel substrate to the brain, which normally relies on glucose. But in certain situations, the brain can't rely on glucose, for example, with traumatic brain injury. Certainly in the setting of Alzheimer's disease where the brain's ability to generate ATP from glucose, ATP is the brain's primary energetic currency, is diminished by about 50%. And so if you're able to essentially keep the lights on, so to speak, by providing the brain with this alternate fuel source, then that's a really powerful idea and needs to be studied. And there have been a number of studies

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  48. Yeah, I'm pro the ketogenic diet in certain contexts. I'm not pro I'm not necessarily pro the ketogenic diet in every context you don't need to be on a ketogenic diet for weight loss I think that's a big misconception But the reason why I talk about it, I mean, you have to understand the context of the ketogenic diet within genius foods, which is that from the standpoint of the brain, it's a very important diet. It's an important diet to study. It's an important diet to talk about. As I've mentioned, we've been using it to treat certain types of epilepsy for

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT

  49. Trustworthy screening tools. So similarly, ultra-processed foods, yeah, there are definitely some exceptions, but in general, they're a food category to be minimized.

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  50. But just in general, ultra-processed foods are a big problem because they tend to be not the best for us. Like the majority of ultra-processed foods that people are consuming are refined grain products packed with added sugar, excess sodium. Sodium's not bad, but like, you know, we tend to overconsume it today because of its presence in these ultra-processed products as used as a flavor enhancer. So yeah, so most ultra processed products are bad. And it's sort of like the analogy that I'll draw, it's sort of like the BMI. I don't know if you're familiar with the BMI, but BMI is a way that it's a screening tool for obesity. So when you look at the population level, most people with a certain BMI.

    2023-02-20 · The Diary of a CEO · The No.1 Health Expert: The One Food (WE ALL EAT) That's Slowly Hurting Us!: Max Lugavere · IDENTIFIED FROM THE TRANSCRIPT