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Nathan Bryan

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2026-04-03
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2026-04-03
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  1. And there's other benefits of light. You know, it can stimulate mitochondrial biogenesis. It improves energy production. It can lower blood pressure. Lots of benefits of light therapy. And yet we're programmed to not go outside. If we go outside, put on SPF60 and intoxicate ourselves with these cancer-causing chemicals and sunscreen. It makes no sense.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  2. Think it's doing the things that disrupt it. Get rid of fluoride, get rid of mouthwash, stop using N acids, stop eating sugar, anything that leads to an elevation in blood sugar, a balanced diet in moderation, moderate physical exercise, 20-30 minutes of sunlight a day. Sunlight, there's certain both ends of the visible spectrum, both are the UV spectrum and the full spectrum infrared. So those frequencies and vibrations, again, stimulate nitric oxide release. So the UV has enough energy to where it'll knock nitric oxide bound to a cysteine thiol and protein. And then the UV spectrum will release nitric oxide down to metals.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  3. Of the frequency and activating the nitric oxide synthase enzyme. You take older patients, and we've demonstrated this, it's published years ago, and other groups have demonstrated this, older patients that their enzyme isn't making nitric oxide, whether they do nasal breathing or whether they do humming, there's no nitric oxide coming up. So again, this is an activator and a stimulator, but it's dependent upon the function of the enzyme that makes nitric oxide. If your enzyme is broken, humming nasal breathing, exercise,

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  4. Well, if you just like what you do in meditation or just simple humming, you could actually, so if I had my ozone or gas phase analyzer here, I could hum. And I could detect nitric oxide coming out of my exhaled breath.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  5. Humming, you know, there are certain frequencies. We've done this in looking at nitric oxide coming out of the exhaled breath when you're humming. So certain frequencies can activate this enzyme, and it's dependent upon the volume of the nasal sinuses. So there's not one frequency that would work in every single person. Because the volume of your airways and oral cavity and sinuses was probably much different than mine.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  6. So you have to, I mean, I'm a big fan of mouth taping, but for me, I know, and I watch my kids, but sometimes there's anatomical issues where there's obstructive airways and airway obstruction that has to be corrected by dental appliances or sometimes surgery. But the worst thing you can do is tape your mouth and your airway be constricted and suffocate. So before you do mouth taping, you need to get some imaging done from your dentist to make sure that your airway is open to where if you're forced to breathe through your nose, you can actually have oxygen exchange.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  7. I think the benefits of that are pretty well and mechanistically we understand the benefits of it. So the mouth breathers are not only bypassing this natural nitric oxide production pathway, but when you mouth breathe, it completely changes the microbiome. So you're not only bypassing the nitric oxide producing in the upper airway, but you're inhibiting nitric oxide production in the mouth from the microbiome because you're fully oxygenating the mouth. It's changing the pH of the saliva and completely changes the microbiome and completely shuts down nitric oxide production

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  8. Oh, yeah, again, going over the past 20 years. Know, I think there's a lot of people, I mean, obviously your girlfriend, there's Patrick McCohen. The

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  9. When we talk about the enzyme that's found in the lining of the blood vessels, we started this segment that same enzyme is found in our epithelial cells, in our upper airways, in our sinuses. So just like exercise can activate nitric oxide production in the lining of the blood vessels, deep breathing, nasal breathing activates that enzyme in the epithelial cells of our sinuses. And so when we do nasal breathing, it's activating the enzyme to make nitric oxide. And now we're delivering that nitric oxide gas into the bronchials, the lower airway. It's dilating those bronchials. Moreover, it's dilating the pulmonary arteries. So now we're improving oxygen uptake, oxygen delivery, and that's why nasal breathing and deep breathing has been shown to lower blood pressure.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  10. Oh, so give us guns. So, number one, it's got aluminum in it, which you should absolutely be avoided. But yeah, that just, it looks like a buffer. It's got an hydroxide, aluminum hydroxide, which is a strong base. So it's neutralizing the stomach acid production. But it's a neutralizing agent, but anything that contains aluminum, you should absolutely avoid it.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  11. Well, there's certain classes of an acids. There's what we call H2 blockers. There's proton pump inhibitors, and then there's the natural buffers that are just kind of neutralizing the acid environment in the stomach. Gaviscon, I'm trying to think. What class that falls under? I don't think it's widely used here in the US. I mean, the main drugs used here are proly next prevised. Those are the over-the-counter. And then the main prescription medications are the Omeprazol and the Pentoprazo.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  12. So, there's a difference, and so Tums and things like baking soda are a buffer, right? Sodium bicarb or calcium carbonate. And it's a buffer, right? So if you have an acute bout of hyper secretion of acid, you can take a TUMS or some buffer, some base alkaline substance to neutralize the acid. Neutralizing acid is completely different than inhibiting its natural production in the polyoric cells of the stomach.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  13. These are like the Prilocyk, the previsids, the Nexium, the prescription medications, or Omeprazol, Pentoprazol. Today in the US, I think it's probably worldwide. You don't even need a prescription for these from your physician. You can go to your local drugstore and you can buy these what we call proton pump inhibitors or PPIs.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  14. So it's a medication that's given orally to suppress stomach acid production. As a biochemist and physiologist, I can't think of nothing more damaging than to inhibit stomach acid production. Stomach acid is required to break down proteins into amino acids, whether it's you're eating animal protein or plant-based protein. It's required for nutrient absorption. You need stomach acid to absorb bee vitamins. You need stomach acid to absorb selenium, chromium, iodine, magnesium, iron. I mean, most nutrients, micronutrients, are absorbed in the lumen of the stomach. And if the stomach is not making stomach acid, then these nutrients are not absorbed. And most Americans, 75% of Americans are deficient in magnesium. 95% of Americans are deficient in iodine. I mean, it's a huge problem.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  15. Oh, yeah, from 2004 to 2000, so a 20 year period, we're seeing At almost a quadrupling of the use of antacids. And this is globally, or is this in the US?

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  16. Because, as again, through our survey that we published in 2015, we realized that you really can't eat enough. Improve your performance, and the other caveat is that if you're using mouthwash, you've got fluoride in your toothpaste or fluoride in your drinking water that you're mixing the beet powder in, you're not going to get a nitric oxide benefit from it.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  17. But if you go back to historical times and you look at the hieroglyphics on caves of the ancient cavemen, People thought they were drinking wine because they would have these red stuff in this before battle. But what these ancient Egyptians were doing was they were drinking beet juice to improve their performance before they went into battle so that they were ready, they were energized, they improved their circulation. So that's the historical study on beets. And obviously these were beads grown at a time when there were no herbicides, pesticides, and the soil was probably fertile. So these beets were full of nutrients, probably full of nitrate that provided the benefits of that. But unfortunately today, the beets that are grown, at least in America. Really, a nutrient depleted, just like most of the food

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  18. What I tried to do in that book is educate okay, what is it about beats that are so important? What's the mechanism and what is necessary in those beats that can improve nitric oxide production? So again, everything I do is intended to educate and inform the consumer so that they know how to make informed educated choices on the products they're taking or the foods they're eating or their oral hygienic practices.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  19. Didn't contain any nitrate, no nitrite. They were just, we called them deadbeats. They're deadbeat product. And so I thought if consumers are out there looking for beets because they've been shown to enhance their performance, That enhancement and performance was dependent upon the beat's ability to improve nitric oxide production in the body, then the non-scientists out there wouldn't know what to look for. They're buying products that aren't providing any benefit to them So, years ago, we would do randomized placebo controlled clinical trials and we would take some of these commercial bead products that you can go to your local nutrition store or pharmacy, buy off the shelf, and we would use those as placebos in our clinical trials because it's the perfect placebo.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  20. The beats hit the really the airways back in 2012 in the London Olympic Games There was a lot of data coming out at the time of the benefits of beetroot juice on enhancing athletic performance. And there was a benefit of the nitric oxide being produced that could explain the improvement in athletic performance. Problem is, these athletes were drinking leaders and leaders of beetroot juice and causing a lot of gastric discomfort, causing diarrhea, their urine, and their feces would turn red, and a lot of people interpreted, misinterpreted that as gastric bleeds or urinary bleeds. And then when I started looking at the products on the market, most of the beet products, the desiccated beet powders, provided zero nitric oxide benefit.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  21. Yeah, you got to eliminate sugar. And I think the benefits of it like a straight ketogenic diet or a straight vegan vegetarian diet is just the elimination of sugar and carbs. But I think to answer your question, what should we be eating? I think you've got to eat a balanced diet in moderation. You know, Americans are overfed. All you got to do is walk around and see the epidemic of obesity. Good high-quality protein, good quality fats, and little or no carbs. And it's really that simple.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  22. Turn it around one pump from the other. Now, if you apply that and mix it together as soon as you mix it together, it starts to generate nitric oxide gas. So then that gas will diffuse into that tissue. It's going to increase blood flow. It's going to mobilize stem cells and it's going to improve cellular turnover and completely remodel that and heal that. And if it were an infection in there, it would kill the infectious bacterium.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  23. Apply the nitric oxide serum, it'll stimulate blood flow to that, it'll improve cellular turnover and heal that wound and basically remediate the scar.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  24. Absolutely. That's why diabetics have a 10 times higher incidence of heart attack, stroke, all-cause mortality. That's why they develop neurological or peripheral neuropathy. That's why they have non-healing wounds. There's no nitric oxide. That's why they're developing diabetic retinopathy. Macular degeneration, pancreatitis. I mean, all of that can be traced back to a lack of nitric oxide production because the sugar is stuck to the enzyme. The sugar destroys the oral microbiome and completely changes the ecology of the bacteria and completely shuts down nitric oxide production.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  25. Well, that's what happens inside the body. That sugar sticks to everything. It sticks to proteins. It sticks to enzymes. It binds to hemoglobin. Sugar stuck to hemoglobin is what we call hemoglobin A1C. And what is that? It's a marker of long-term glucose control. If you have a hemoglobin A1C of greater than 5.7, you're diabetic. So it's not just hemoglobin, it sticks to the enzyme that makes nitric ox In biochemistry, in entomology, enzymes have to be able to undergo conformational changes, right? So it transfers electrons from one donor to an acceptor, and that's how biochemistry is done. But if sugar is stuck to that enzyme, it locks it in some confirmation and it can't do its job. It can't make nitric oxide. So sugar is an absolute poison and it kills many enzymes and binds to everything.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  26. Because sugar is a toxin, it's a poison. And let's think about what sugar is. So when we eat sugar or drink sugar beverages, right? Whether it's sucrose, whether it's fructose, whether it's high fructose corn syrup, the end result inside the human is we see an increase in glucose. So elevation in blood sugar or blood glucose is diabetes, right? And now there's continuous glucose monitors that you can get anywhere. And everybody does this. So if you eat something and it causes an increase in your blood sugar, blood glucose, then you should avoid that. Because glucose, as the name applies, is glue, right? It's sticky. And if you have a soda and you spill it on your countertop, you come back the next day, it's sticky.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  27. I think the same answer is for that too. It's not so much what we should be eating, it's what we should not be eating. We'll cover those step by step. Number one, you have to avoid sugar and high glycemic index foods.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  28. I mean, there's other agonists too, like vitamin D. I mean, most Americans are deficient in vitamin D people with low testosterone have erectile dysfunction. Why is that? Because they're not stimulating nitric oxide production and they're not dilating the blood vessel. So they develop ED. So all of this, no matter what it is, whether it's related to vitamin D deficiency, which is activator and stimulator of nitric oxide, if it's low hormones, if it's a poor diet, sedentary lifestyle, all of that can be explained by insufficient nitric oxide production.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  29. As long as the enzyme is functional and coupled. Means that we have to understand the entomology and about chemistry of that reaction to where when it's exposed to testosterone, the cell can actually make nitric oxide in response.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  30. Yeah, so this is a two way street. So in men, testosterone activates nitric oxide production Women, estrogen activates and stimulates nitric oxide production. So, as long as we have optimal sex hormones, and as long as the enzyme and the lining of the blood vessel can functionally produce nitric oxide, that explains the cardio protective benefits of hormone replacement therapy.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  31. Because you're killing the oral microbiome that's partly responsible for production of nitric oxide. And nitrogen without nitric oxide, you get constriction of blood vessels.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  32. Yeah, there's also data showing that if you use mouthwash, you lose the cardio protective benefits of exercise. So think about this. We know that diet and exercise is the best medicine Many people aspire to do that. They go and they try to eat good, they avoid the temptations of sugars and sweets. They exercise every day to try to increase their longevity and cardiovascular health. You do that and you're using mouthwash, you no longer get the benefits from exercise. And we've already established you don't get the nitric oxide benefits from diet. So two out of three Americans wake up every morning and use mouthwash. And two out of three Americans have an unsafe elevation and blood pressure.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  33. I think that's a good proactive practice. But, you know, because you need to look at the health of the gum tissue and the gingival tissue and a routine clean and scraping the plaque off the teeth and making sure you have good mineralization of the enamel of the tooth is good, but never let them do a fluoride rinse on you.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  34. Just think about this your tongue scraping, you're opening up the pore And now you're using mouthwash, it's better to, it can easily penetrate deep in the crips of the tongue and more effectively kill the bacteria.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  35. That regard, yes, but what we found was in that one kid we saw the greatest increase in blood pressure. If you tongue scrape and use antiseptic mouthwash, that's the absolute worst scenario.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  36. That biofilm. Yeah, you take the back of the dorsal tongue. I mean, almost to the point of the gag reflex, and you just pull that, ideally copper tongue scraper forward, and you're going to see this goop. Coming in there, but it's kind of like tilling the soil, and it's increasing the diversity of the dorsal part of the tongue, the microbiome.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  37. So you have to till the soil, right? You got to break up the soil so the seeds actually can be aerated and you just break up that

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  38. Now, tongue scrapers, the data, again, that's time tested. That's an ancient practice. And even in our study, we found that people who do tongue scraping have a more diverse oral microbiome and they seem to have better oral health.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  39. Everybody that I know fills the entire bristle of the toothpaste with toothpaste. So that's about 10 or 15, sometimes 20 piece size amounts of toothpaste. And a pea size amount of toothpaste contains about half a milligram of fluoride. Now, if you're using 10, 20 times more than that pea size, now you're exposed to five milligrams, 10 milligrams of fluoride. And you don't even have to swallow it. This is a very small molecule, a molecular weight of 19. So it's absorbed directly across the bucal mucosa, the oral cavity, and it becomes systemic.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  40. And it shuts down your thyroid function. And it's a neurotoxin. And as I mentioned before, most toothpaste has fluoride in it. And if you read the back of your toothpaste, it will tell you, at least in the US, I don't know about in other countries, but it says, if you swallow this, call poison control. It's a poison. They're putting poison in toothpaste. And then if you also pay attention, it says only put a peace amount of toothpaste on your toothbrush, a pea size.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT

  41. Well, I think the most important thing we've learned is what you shouldn't be doing. So it's not what should we do, it's what we shouldn't be doing. Number one, we have to get rid of fluoride. You know, just this past weekend, I was speaking at a dental conference in Salt Lake City, and there were there people there from the National Toxicology Program, which in the US is the organization tasked with if there's any kind of risk of exposure of environmental toxicant, they're charged with doing the toxicology studies to see if there's an increased risk. What is the risk? And is there a safe level that is without risk? And what they report is that fluoride There's no benefit of fluoride and it's all risk. It lowers IQ in kids by as much as seven points.

    2026-04-03 · The Diary of a CEO · Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan · IDENTIFIED FROM THE TRANSCRIPT