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Dom D'Agostino

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2015-11-03
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2015-11-03
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  1. “I don't have that problem too much now just because I have my diet under control. But yeah, I think sometimes I face that resistance a little bit. So I feel like I kind of have to prove myself still.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  2. “Okay, I think probably the best way would be the ketone nutrition website.org and I have that and yeah Facebook and I probably use that more than Twitter”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  3. “That are genetically kind of predisposed to accumulating those plaques. And I think that would be, you could probably draw some parallels from that work with the neuro inflammation and the neurotoxic effects that Lyme's disease kind of has. And that's what I'm not, Lyme disease is not something that I study, but I just come across it a lot because hyperbaric oxygen has been used to sensitize sort of the bacteria to the antibiotics. So a lot of people ask me questions and I have to go. I've been staying up on top of the literature kind of in a peripheral sense because it's not my kind of core of study. But everything that I read really focuses on the Neuroimlammation that's resulting from the spirochet.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  4. “And I think that would ultimately contribute to, I don't know how you would quantify that, but we, I'm trying to think of studies that we've done sort of in parallel, we did some work in an Alzheimer's model, and I think that the Lym has been associated with tau and amyloid plaques and neuroinflammation that can contribute to those plaques. And I think being in a state of ketosis, even there's some work with exogenous ketones and calorie restriction or even intermittent fasting things can limit the accumulation of some of these plaques that are associated with neuropathologies such as Alzheimer's disease, the amyloid and the tau plaques. And this can be shown in animal models.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  5. “Yeah, yeah, I think so, especially in certain tissues, you know, we know muscle is incredibly plastic, but if you're exercising and in a state of ketosis that you can build up your mitochondria and you'll do that more efficiently if you're on a ketogenic diet. And I think even in the central nervous system, which may have taken a big hit from doxycycline or Lyme disease, the central nervous system is running more efficiently in a state of ketosis, I believe, especially if you can dampen some of the neuroimmammation that's associated with the disease.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  6. “Kind of fundamentally turning down the generation of superoxide anion by enhancing mitochondrial efficiency. Not only do we make more ATP through ketone metabolism, but we're also enhancing the flux of substrate utilization and energy production from that substrate, even glucose substrate by enhancing mitochondrial bioenergetics and the ketones we know can do that through a variety of mechanisms that I can get into. But basically, yeah, I mean, you can derive more energy per oxygen molecule. With ketone metabolism”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  7. “By ketone metabolism can enhance the energetic flux through the mitochondria to produce ATP, our energy currency. And at the same time that it's enhancing the bioenergetics that the mitochondria, it's also preventing the formation of superoxide anion, which is an oxygen-free radical or reactive oxygen species, and that's the precursor to more reactive oxygen species like hydroxyl radical and peroxynitrate and things like that. So by”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  8. “Yeah, so ketones are very efficient metabolic fuel. And in studies that were done in animal models and were looking at the muscle biopsies too, shows that if you're in a state of ketosis relative to a higher carbohydrate diet, that it can increase mitochondrial biogenesis and mitochondrial efficiency. At the level of the cell When we talk about efficiency, I don't want to get down into too much specifics, but there's the electron transport chain is...”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  9. “Inflammation is really, did you happen to get blood work and look at, because the spirit really, that's how it wreaks havoc in your system. I mean, by activating your immune system, but also just wreaking havoc, you know, as far as causing systemic inflammation in the body.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  10. “So I think that may have something to do with also the It spikes in blood glucose, higher insulin levels all can contribute to inflammation and inflammatory processes, so putting a dampening on that situation with a ketogenic diet and having elevated levels of ketones could impact the primary malady that's causing the symptoms, which would be the inflammation, the encephalopathy, the inflammation of the white matter, I think. cognitive, emotional states are altered in people. And I think it can just help bring your nervous system back to a state of homeostasis, similar to what it's doing for other disorders.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  11. “Well, I'm from New Jersey, so London is really, you know, I knew a lot of people, especially growing up in a family that was hunters and knowing most of my friends were hunting in the woods. I grew up in the woods. Somehow I Didn't get Lyme disease. Never been tested for, but never really had any symptoms for it. So Lyme's disease really produces pretty profound inflammation and the spirachetes can cause everything that you describe, fatigue, but I think they can cause from a neurological perspective they can cause encephalopathy. essentially is resulting from neuroinflammation and ketones, the ketogenic diet and ketones in particular have pretty profound anti-inflammatory effects and especially in relation to the nervous system since ketones are freely permeable to the blood brain barrier and kind of bathe our nervous system.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  12. “Is actually the name of the book, the biography of cancer. That book kind of talks about the history of cancer. Tripping over the truth is similar to Mukherjee's book, but viewed from the perspective of understanding cancer as more or less a metabolic disease and how we could develop therapies to target it from a metabolic perspective. And I've given that book probably bought seven or eight copies of that book over the last year and given it away and everybody has come back to me and said that book was fantastic. I mean, not only is it informative, but Travis is like an unbelievable gifted writer.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  13. “So that book, and oh, another book by a guy that I'm actually working on a project with him now. His name is Travis Christopherson. He wrote a book called Tripping Over So tripping. Yeah, and he wrote a precursor to the book. He wrote an article that was appeared on Rob Wolf's blog. And actually I have an article written with him that's going to appear on the blog on Thursday. It's about the history of the ketogenic diet. I think Rob's going to put it on the blog on Thursday, I believe. But Travis is a brilliant, he's probably one of the most gifted writers I've ever known. So tripping over the truth is basically the story of the story of cancer, really. I mean, it's a great history of cancer that comes at it from a different perspective from the Mukherjee book, which is the biography of cancer that is pretty popular, New York Times bestseller. It's been on The Emperor of All Maladies.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  14. “Yeah, yeah, screw tape letters is really good. I don't think I've given that to, but I've given the language of God to some of my friends and they really enjoyed it. So that would be one. And then a required reading for my students would be Tom Saferud's book, Cancer as a Metabolic Disease. So that's a really, I mean, I think it's sold pretty well in Amazon. And it's highly, highly technical, and it's unfortunate. It's like really expensive. So it's about $100 to $130, I think. Maybe you can get it cheaper. You can get used versions for probably like 50 bucks online. But if you want a really good kind of description of, I guess, cancer as a metabolic disease, the science, the history, I mean, it's really well written, Tom did, he's a collaborator of mine. He worked.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  15. “For cystic fibrosis. So the language of God, it really inspired me because I had no idea that a scientist of his stature could have such a devout faith. And that kind of influenced me and it got me to reread some older books I read by C.S. Lewis, the screw tape letters.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  16. “And then as I got into science and became a scientist, and my advisor was funded by the NIH, and I was always told that I needed NIH funding to be a career scientist. And then I met the NIH director, Francis Collins at Society for Neuroscience meeting. And I was like, well, I should understand the mind of Francis Collins and understand what is the director of basically the president of science thinking. So I went to try to find some biographies on him. And when I did a search, I found a book, The Language of God. And I thought, you know, that was really, I didn't, I had no idea of his sort of his spirituality or his kind of worldview besides outside of science. I know he spearheaded the Human Genome Project and was pretty instrumental in finding the gene.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  17. “Yeah, personal power. So I bought the book too. And I liked it so much like I bought it and I gave it to all my lifting buddies, you know, and they didn't, you know, they went off to college and everything. And years later, like two of them contacted me and like, you know that book you gave me? It changed my life. You know, I did better in college and everything. So I would say Anthony going way back, personal power, Anthony Robbins book was kind of influential from, you know, back in the day.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  18. “That's a good question. Yeah, I would have to well go in back in the college days, I would say Anthony Robbins, I listened to his stuff when I was my senior year in high school. And I listened to like this 30-day tapes back when I was.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  19. “Yeah, Ellen Davis, ketogenic diet resource. Definitely one of the go-to places. I have a website, keto nutrition.org, and basically it's like a skeleton website is compiled a lot of useful links that I thought and her website's on there, her books on there. So that's keto nutrition.org.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  20. “Yeah, I think probably the best place to go would be ketogenic diet resource. And that's a website, Ellen Davis has that website, and literally that's the name of it, ketogenic dietresource.com. And it's like a ton of information on there. Pretty much every question you'd ever want on there. We even, she put together a book for ketogenic diet and cancer, one for the ketogenic diet for type 2 diabetes. It was co-authored by a doctor that's actually in my area that has type 1 diabetes that uses the ketogenic diet for that. So that's an incredible resource.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  21. “Purely ketogenic. And oh yeah, I also will take a tablespoon of coconut oil, especially if it has the frozen blueberries in it. And if I drizzle it around and stir it up, the coconut oil will sort of harden and make these little crunchy chocolate things. So it actually tastes like you have chocolate chips in there, if that makes sense. You know, coconut oil? Yeah, so my fiance is totally not ketogenic. I mean, she has an enormous carbohydrate tolerance and she just thinks what I do is really strange. But if I make this and she's a big fan of regular like Briars or Hagen's chocolate, and if I give this to her, she thinks it's incredible. So even someone who's not ketogenic and doesn't eat this way and has a sweet tooth thinks this is really good.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  22. “People ask me that question a lot can I have dairy? And I do have dairy every day, but I've switched out my nighttime snack, switched out the sour cream to either a mix of sour cream and coconut cream together. And sour cream is really not sour, right? I mean, especially if you buy the dark chocolate baking cocoa, the extra dark, and it's a little bit bitter. And if you add it to it, it's sort of neutralizes any remote little sourness that sour cream has. And it makes a really delicious chocolate mousse.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  23. “And I was getting in extra fat throughout the day with heavy cream. And I did an experiment because I wanted to determine what happens if you have surplus amount of calories in the form of dairy fat. And if I did that for two weeks. So I got like a thousand extra calories per day, 500 to 1,000 extra calories per day for two weeks. Then I went in and got like an NMR, you know, lipidomic profile of everything. And it really shot up some things remarkably like my LDLP particle. And I'm still analyzing it right now. I'm kind of still doing experiments on myself. But I went back and I did, I cut out the dairy and I replaced it with coconut cream and all those numbers came back down. But I still get dairy informed. Of butter, and I just don't go too overboard with it.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  24. “Which are higher in fiber, not real sweet, but higher in fiber. And I stir that into it. And sometimes I'll do it'll be a pretty big bowl. I'll do like two cups of coconut cream or two cups of sour cream. So I was doing a lot of, I have a whipped cream maker that I put heavy cream in and I would put whipped cream on top of that and I would In my whipped cream maker, I would put the heavy cream in, then I put Stevie in. So I'd sweeten the whipped cream a little bit, you know, shake it up and charge it with a little things.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  25. “Yeah, a little bit of cinnamon. And it's like a fat bomb. So people ask, where do you get all your fat? There's a lot of fat to eat to get in about 300 grams of fat a day for the diet. So yeah, so that's like a fat bomb. It's about a fat, I think. And what if I eat that at night time and if I work out or if I haven't gotten like any carbohydrates during the day, I usually put in like a third of a cup or even a half cup of wild blueberries.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  26. “I have to go back and look at the brand, but you can get it on Amazon if you just go to bulk Stevia Powder and it comes in like a two pound or one pound container. And it's, yeah, it's kind of like the generic. I've tried like every brand of Stevia and this is powder. It's pretty good. It travels well and everything too.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  27. “Stevia, just sweeten it to whatever you like. I have the super concentrated stevia, so I just put literally a pinch of it in there.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  28. “And then I always have dessert that's kind of unique, actually. I call it my, I don't know, keto moose or keto ice cream. And what it essentially is, is it could be sour cream or coconut cream? And I take sour cream. So the easiest thing, take sour cream or coconut cream and take maybe about a cup of it or two cups, cup and a half. And then I put a tablespoon of dark chocolate baking powder in it, some cinnamon, a pinch of salt and stevia, and stir it up until it's like a thick mousse. And then I stick it in the freezer. And then I go kind of do my things and, you know, shower, get ready for the day or whatever. And then I take it out and the freezer, refrigerator, and it's basically like ice cream to me.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  29. “Yeah, like 50 grams. That would be like my bolus, like probably one of the larger protein meals. And if I work out, if I happen to work out, which I did yesterday, I would probably eat a little bit more, maybe about 60 or like 70 or 80 grams of protein. And that'll be kind of like my larger meal of the day. I'll have a salad, some kind of fatty protein. And last night I cooked Brussels sprouts and I kind of cut them in half face down and cooked them in butter and olive oil. No, butter and coconut oil. So they suck it up. And so I think of vegetables as like a fat delivery. So same thing with colliard greens or asparagus. They're usually cooked in a lot of butter, olive oil, coconut oil. And I'll have that. So I'll have some kind of fatty protein, some kind of vegetable cooked in fat and salad.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  30. “Yeah, I usually get like mixed screens, like two or three different types of salads, like usually spinach, a mixed screen, and two different types of mixed screen bag salads, and I mix them together. And I get like a good quality extra virgin olive oil. And I will, what else did I put in it? Artichokes actually avocado artichokes olive oil and I put MCT oil on as salad dressing too and so I'll make a salad and maybe a little bit of parmesan cheese on it or feta and we have typically like chicken you know which would have the skin on it beef or fish and it's usually like the fattiest Versions that we can get. And I don't go too overboard on the protein like I used to. So pretty moderate amount of protein, maybe about 50 grams of protein, and then some kind of vegetables.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  31. “Yeah, like it has that. It's got Five ingredients that are formulated really well that enhance acetylcholine transmission, enhance dopamine. There's just enough caffeine to give like a stimuli, I think about 100 milligrams of caffeine, and it's just, it's a good product that I keep on hand. And a lot of thought went into the formulation of it with the ratios of things. So if you're looking for a lift, a boost, sort of a nootropic utopian is definitely something that I keep at the corner of my desk. And I use it kind of sparingly, but I'll use it a couple times a month.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  32. “I made de novo, you know. So D Novo nutrition makes some really interesting products, and I'm really particular about products that I use. And the one product that they have is called Utopian. And they also sell probably the highest quality whey protein to. But utopian is a product that I use sparingly. I have it packed in my bag now because I'll be traveling in Europe. And it's basically like a cognitive enhancement agent that also promotes sort of a well-being. And you might call it a, you know, it's a mild nootropic and a mild stimulant. And it's just got some standard things in it, like Cooper Zine. You might be familiar with that.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  33. “Yeah. Yeah. And when I had my breakfast, I will make, I'll have a cup of coffee, but I have a thermos that I bring with me to work. And in that thermos, I cut a stick of butter in half and throw it in it. And then I put a scoop or two scoops of MCT powder. And then I pour the rest of my coffee that I make in French press in that. And then I just kind of...”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  34. “I have the powder in the oil sometimes, and I cook in coconut oil, and I'll cook with a combination coconut oil and butter. So I'll put a pad of butter with like a spoonful oil in a pan and cook my eggs in that. And the sardines, if I have sardines in the morning, it's packed in extra virgin olive oil, which I like a lot of. I was eating a lot of dairy fat and I noticed my LDL went like really high and my LDL particle number went up. And that's kind of like a whole nother conversation. But I was kind of doing an experiment on myself. So I haven't phased out dairy completely, but I backed off on it a little bit and been using more coconut cream in place of regular cream. So, yeah, so in the morning, I kind of describe my breakfast already, but at nighttime, what I like to have would be I always have a salad.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  35. “A green leafy salad with a lot of olive oil and maybe some feta cheese and some bulletproof coffee or something like that combined will not kick you out of ketosis. You can just stay cruising in ketosis. So this is, I think, needs to be appreciated.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  36. “Yeah, I think the staple ones that I like are actually artichoke is on that list. Spinach, kale, broccoli, asparagus is probably at the top of my list. Celery a little bit so any kind of green leafy vegetables like salad, I have a salad every night and with mixed greens and a lot of olive oil. And take your always eat your vegetables with a source of fat. I think it helps promote that you getting the most nutrition out of vegetables. And also if you mix your food so you're eating your protein with obviously high fat and fiber will definitely help you stay in ketosis because if you just bolus protein a lot of people say their own acetenic diet just by eating like no carbs but like a chicken breast will quickly kick you out of ketosis but a chicken breast cut up into”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  37. “Yeah, if you get too many amino acids getting into the liver as a source of fuel for gluconeogenesis, but also protein can stimulate a release of insulin. And insulin is very anti-ketogenic. So it's a combination of attenuating the rise in amino acids, which will attenuate the rise in glucose, which will attenuate the bump in insulin that you could potentially get from that. So fibers are pretty, fiber is actually really useful.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  38. “And that fiber can be ketogenic. And fiber can also assist in helping us stay in ketosis by being a buffer when they're eaten with protein because it helps slow the digestion, assimilation, and utilization of protein. So you get less of a spike in amino acid levels, which can help a spike, a quick spike in amino acid levels can shut off ketogenesis. And if you attenuate that spike, it can help promote your body into staying in that state of ketosis longer by.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  39. “Ketosis, and I think that one could formulate a ketogenic diet with the intention to further enhance ketosis by adding certain types of fiber soluble fiber that are broken down into short-chain fatty acids, which are potentially ketogenic. Like your friend that had the artichoke and had a big bump in ketones, that's really interesting. I love artichokes and maybe that's why I get levels of, so I'm looking at the macronutrient profile of artichokes now. And I see that, yeah, they're primarily carbohydrate, but mostly fiber.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  40. “Yeah, that's an interesting observation with the artichoke. Artichokes, you know, mostly fiber, really. And I guess that could lead into the next question, right? Soluble fiber breaks down into short-chain fatty acids, which are ketotic. So I was actually at NASA a few weeks ago, and it was brought to my attention by a former astronaut, Rick Lenahan, who's also a vet, that cows are ketotic and that they And this gets back to your sort of the thing we were talking about, about short-chain fatty acids being formed from the breakdown of soluble fiber and short-chain fatty acids can be a form of ketones, can contribute to ketogenesis. And also the generation butyrate in the gut, which can enhance and contribute to our gut microbiota. So yeah, so I think that needs to be appreciated that we were talking about foods that could enhance”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  41. “Any side effects at doses that would even approach, you know, kind of what's on the label there. And you have to figure when these things are ingested, it's bioidentical to what our body makes anyway. And even if we eat an egg or a piece of, if we eat muscle from an animal that's inkosis, we're getting ketones, you know, exogenous ketones. We're just not getting it at the level that would really put us into ketosis. I think milk, there's some ketones in milk in different products that could kind of boost your ketone levels a little bit. So we sort of looked into that when we were trying to understand for FDA regulations are ketones in our food. And yes, they are in our food if in animals in ketosis and we're eating milk from an animal or the meat from an animal's in ketosis. We're technically consuming exogenous ketones”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  42. “Not when administered that way. So in taking a step back, if we were to give twenty five grams per kilogram as a single dose of our most potent ketone ester, that would cause ketoacidosis in the rats, for sure. Because we got, and then they would, that would be hard to reverse, actually. But that would be such a, I don't even think that volume is possible. I think the Ayakuk wouldn't even allow us to administer that dose because the volume would be so high for the stomach. You know what I mean? So it would be really, really high. So we haven't seen any...”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  43. “25 grams per kilogram. So instead of delivering it like they do in drug studies with one dose, we formulated it into the diet. So we figured out how much of food the animal ate. And then we took that and we formulated it in a way that we know that if they ate this amount of grams per food a day, they would be getting this amount. So instead of getting it at a big dose once a day, they would eat it, they'd nibble on it throughout the day. And that's kind of a more realistic way to give it instead of doing most drug studies or even food studies are done with food additives. They just give it in a bolus. I didn't see anything. There's no negative effects.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  44. “And if there was toxicity, we would be able to pick it up most likely in the clinical chemistry, which we've done that. And we've also, on top of clinical chemistry and the histology, we also looked at all about 27 different types of cytokines. And we didn't see anything relative to the control, whether relative to the standard rodent chow. There were no abnormalities to indicate liver or kidney stress. And on top of that, we did kind of parallel to this in the same group. And that was at the...”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  45. “Histology is where we at the end of the study, we harvest all the organs, right? Like the kidneys, the liver and heart and everything, and we weigh them out and then we take the organs and then we basically treat them in a way where we can section them and make slices of them and look at the cells. So we can look at the liver, for example, or the kidneys, and then we can examine at the level of the mitochondria inside the cells. We can examine these cells to determine whether the agent that we administered caused any toxicity to the animal, to the organs. Got it.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  46. “From Esther's to the salts to combinations thereof at 25 grams per kilogram per day. So that's really high, right? So we did that. This is part of the toxicology studies that we are doing to get FDA approval for different things. And so they actually just required 2.5 grams per kilogram per day. Well, I was like, well, let's increase that tenfold. And we formulated it. I come at this from the FDA may see this as a drug, but I see ketones as a fourth macronutrient, right? You have fats, you have proteins and carbs, ketones are an energy containing molecule. And they're like water soluble fat molecules. So we formulated them into the diet and we fed it. We fed our rodent models this, and we did clinical chemistry. We were doing metabolomics, we do histology, we do actually some anxiety studies. What is history?”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  47. “Exactly. I mean, that's the same thing with MCT, right? You're limited by your ability to transport it across the gut. So the mineral load that you would get from the keto cana product would cause an osmotic issue in the gut. And it's great if you want to stay regular. So it stimulates peristalsis in the gut. So you'll get that side effect probably if you exceed. For me, I could probably do up to five or six servings a day and be okay. But as far as toxicity, and this is where we can draw off some of the rat studies we're doing, we just finished a 15-week study in rats, and it's like equivalent to like, you know, a year or two years in humans where we fed a variety of ketone supplements.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  48. “Okay, so it says do not exceed three servings per day. So you will, the... The GI intolerance will far exceed sort of the biological intolerance.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  49. “Things out there that you can take, like Fenibut or GABA that you can take before bed helps you sleep. So the ketogenic diet elevates these things naturally. So that may be offering some sleep promoting potential. But I do think that being in a state of ketosis and having ketones elevated and having them available for your brain can enhance your restorative processes that occur when you're sleeping in the brain.”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT

  50. “in the brain, like the not only the energy to the brain, but the neurotransmitter levels are restored, there's a balance of glucose to gaba, so the gabba levels are restored. And I think that's what's happening too when it comes to sleep. So we know if we do a cerebral CSF, the cerebral fluid of the brain and people that are on a ketogenic diet, it shows that there's a higher GABA to glutamate ratio. So glutamate is excitatory, whereas GABA is kind of like inhibitory. It's kind of like the chilling out neurotransmitter. So there's various”

    2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT