YouSaid · the spoken record

Dom D'Agostino

lines on the record: 181
first: 2015-11-03
most recent: 2015-11-03
sittings or episodes: 1
sources: podcast

Every line below is reproduced as it was said and linked to the record it came from. Nothing here is summarised or generated. Directory · Search · Corrections

“Oh, ideology is like the independent of the cause of the disease. So, for example, glucose transporter deficiency syndrome is actually there's a defect in the transporter that gets the glucose across the blood brain barrier for the brain to use glucose as an energy source. So if a child has glucose transporter deficiency, the only therapy that's offered is a ketogenic diet and it restores fuel flow to the brain so the child can live a normal life. in the in the presence of a persistent molecular pathology like the the glucose transported deficiency and we know the cause we've identified the gene the protein product so even in the presence of that persistent molecular pathology the ketogenic diet can completely like silence the symptoms of that disease and it's doing that by restoring”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“The bioenergetics of the brain when we sleep. And I think that process is more is enhanced or is augmented when you're in a state of ketosis or if you've adapted to living in a state of ketosis. I think our brains are better able to restore homeostasis of our brain chemistry. And I think that metabolic, so enhancing global brain metabolic activity or preserving brain homeostasis or metabolic homeostasis in the brain is a reason why the ketogenic diet is so effective for all these different seizure disorders independent of the etiology. So whether it's a glucose transporter deficiency or what is etiology mean?”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Oh, I'm sorry. There's different brain cells, neurons and glia cells. And among the glia would be astrocytes. And it's thought that astrocytes are, they actually store glycogen, a form of carbohydrates, a form of glucose for the neurons. And it's thought that that may be their function. And that when we go to sleep, the astrocytes can actually build up their glycogen levels. So there's a couple studies that indicate this. And I think sleep is a restorative process, obviously, but I think we restore neurotransmitters and we restore”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“better fuel flow to our brain without the fluctuations in glucose throughout the day. And I think that our astrocytes actually kind of spare our astrocytes.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, I have. I've gotten emails about that. I found a couple, you know, kind of articles on discussing that. And I found that in myself, that like last night I got to bed at 2 a.m. I try to get the bed at like midnight and I woke up at 6.37. So I'm running all four and a half, maybe five hours. And I feel totally fine. I've been pretty productive today. Did a lot of work in the morning best on about six hours as opposed to maybe seven or eight that I felt I required. And that depends on my activity level and kind of what's going on. But generally, I feel like I need about one or two hours less sleep that my requirement for that is less now. And I think there's different reasons for that. And I think when we're in a state of nutritional ketosis, we have”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Not doing that makes me more productive. And I find that eating a ketogenic diet also sustains me levels to where I just get more out of life. I'm more productive. I'm not fixated on food because I don't have to eat as frequently, but because my energy levels are more stable. So I can spend the time doing the things that I think are more productive. And I'm in the process as we speak. This is like the week that I'm submit everything for my tenure. So it's like been super crazy as far as 18 hour days preparing for all this and traveling and stuff on top of that. And I can't imagine doing that living the way I used to live, eating like five, six meals a day and having it timed and everything. I just couldn't do it.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“On a Sunday and put it in bags, in Tupperware, and have it in there and have it labeled. And I was kind of neurotic about it. And, you know, and that's okay. If you're into that sort of thing, and I think it's good, but actually maybe more efficient throughout the week. And no offense against people who do that. But I find that”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Per year, I think, would be something to do. And you'd want to, you know, I would kind of say, you know, time it so it would fit into your schedule. But when I fasted, I did it like right in the middle of writing grants and teaching and all this other stuff. And it didn't. I think it increased my productivity because think about all the time that you spend, you know, preparing food, eating food, cleaning up, eliminating and shopping for food and all these things associated with our fixation on food. And that's kind of time that you save. And I also realized that I was prior to doing this, and this goes back like five, six years ago, I had a preoccupation with food. I thought, and even going back maybe a little bit longer, I thought I had to eat like five or six meals a day, and I would prepare my food, like all my food.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“I've got reports as early as the end of the first day, but I think they're kind of wimps. But usually the second and third day are kind of hurting. If you can cruise through that, and I think cruising through it would be a lot easier with exogenous ketones. So if you're giving your body, you can kind of cheat through that. So this is something that I'm kind of working on, like developing, like thoughtfully developing protocols that would make this whole process easier and even enjoyable potentially. So, okay, like in a perfect world, if you can tolerate fasting, I would do it ideally, yeah, like maybe once every quarter for five days. I think five days is sort of the point where you start to level off everything. Five to seven days. Some of the that work by George Cahill at Harvard showed them kind of leveling off at about 10 days, but they were like severe.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, I've seen several women. It seems to be more pronounced in women that try this, that they faint and they had a couple of them call me up and just, it just made them go crazy. They thought they were going to die. So if you can get past that, and you can get past the feeling of, and that's usually the second and third day.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“When they're trying to sleep. So yeah, that's an activation of your sympathetic nervous system. It's your body saying, hey, this is a stress response. So that's lack of fuel flow to your brain will trigger brain fog. It'll trigger headache. It'll trigger activation of sympathetic immune system. Your insulin levels will go down very rapidly, right? And when insulin goes down, it has a naturetic effect, which means that you lose sodium. So you're peeing out all your sodium. So your blood volume drops, you become hypovolemic and your blood pressure will drop and that'll contribute to your headache and you're just feeling crappy and dizziness when you uphink.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, if you want to do it kind of hardcore. That's kind of kind of my ammo. You're resilient. Yeah, yeah. Okay. And this would apply to someone on a high carbohydrate diet too. But what I've seen, I mean, you just described it very nicely there. The back pain, you know, your body goes into kind of more.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Pretty much, yeah, our immune system is kind of a surveillance mechanism that detects them and takes care of them in our animal models. The cancer cells are kind of, they've evolved to evade the immune system. So that's one of the hallmarks of cancer, right? That it can metastasize, evade the immune system. Now in 2011, they finally added that it has an aberrant metabolic phenotype, but they ignored the whole metabolic thing for a while. But yeah, so the immune”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“I mean, it's putting your physiology physiology into a state that's compromising the tumor tissue. And I always, and I discussed this with my colleague, Tom Safred, he thinks that if you don't have cancer and you do a therapeutic fast once or twice a year, or maybe three times a year if it's a shorter fast, that it would purge any pre-cancerous cells that may be living in your body. So if you put your physiology into a state of fasting ketosis, that puts tremendous metabolic stress on cancer cells that are highly dependent for survival and growth on high levels of glucose and insulin by subtracting them of those growth needs, they can trigger apoptosis, autophagy, and you could potentially purge yourself of some pre-cancerous cells.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“I think it has its place, you know, and you may not want to do depending on your overall health. Like my health, I can tolerate fasting pretty much every day. Intermittent fasting would be no problem. But I think you could derive benefits by fasting, you know, two or three times a week, even once a week. I think could be beneficial. But I would try to do it. Some people do every other day fasting. But I think one meal a day is one way to go about doing it. or alternatively if that's too stressful you could eat two or three meals one day and then you know Monday Wednesday Friday do one meal per day but I think that that gap in time that 20 plus hours that you're not eating and that you have you know met foreman in your system you have DCA in your system and you have exogenous ketones kind of flooding your your bloodstream”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“In the cancers I mentioned before, yeah. And there's application for it. But I think we have to view it this in perspective. DCA, I don't think you can patent it. It's like a really simple molecule, dichloroacetate, right? You can kind of visualize it if you're a chemist. It's pretty small, simple molecule. And it has a pretty powerful metabolic effect. And again, it works well by itself with a high carbohydrate diet. So just think about how it may synergize with the ketogenic diet, exogenous ketones, you know, metformin, intermittent fasting. It's working. It's working through overlapping mechanisms. So you are further compromising sort of the energetic state of the cancer cells by adding it to the mix.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“And that's kind of like a theory that I'm throwing out there, but it's based on kind of what we know, what we see in the lab, and what we know from the literature. But it's relatively a non-toxic drug. I mean, relative to the chemotherapeutic agents that are chemotherapy are highly carcinogenic. So when you're giving chemotherapy, you're giving a highly carcinogenic substance. So it doesn't make sense to treat cancer with something that we know is a powerful carcinogen. So it doesn't. In some cases, it does. Like I mentioned some of the”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Makes the mitochondria, it activates the mitochondria. And if you activate the mitochondria of cancer cells, which have defective mitochondria, it causes the mitochondria to explode and the cancer cells, it triggers apoptosis. So it probably triggers the release of cytochrome C from the mitochondria, which is part of the apoptotic pathway.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, I would start at like 10 milligrams per kilogram, you know, and I'm a little over 100 kilograms or whatever. So you could do the math on that. So I would start up to 10 milligrams per kilogram and probably not go higher than 50 milligrams per kilogram. Because once you get above 50 milligrams per kilogram of DCA, you start to get peripheral neuropathy. And we see this in our animal models, and it's also reported in patients. If you go onto the forums of patients that have gleoblastomas, they'll report tingling in the fingers and the toes at, you know, once they start reaching about 50 milligrams per kilogram. I think the clinical trials use 20 milligrams per kilogram, if I'm not mistaken. So DCA activates pyruvate dehydrogenase complex. So that complex”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Yep, even you can get it 250 milligram tablets or break the tablet in half and keep start out one week, maybe start at 500, and then go up to 750 and then to a gram, and then bump it up to where you start get some GI discomfort. It kills them. It triggers apoptosis in cancer cells by reasons we don't completely have a handle on yet, but it's used clinically for lactic acidosis. And lactate can drive or in the microenvironment, lactate can drive tumor growth. So DCA can actually make your body more alkaline, right? I mean, it's used clinically for that application. And maybe it's therapeutic effects may have to do with that, but we know that if we just grow cancer cells in isolation, like it's associated cell prep and put on DCA, the cancer cells start to die. And at levels that are relatively non-toxic to healthy cells. So dichloroacetate”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“I would do two to four times a day, probably, because the way kind of our experiments are panning out, it just looks like the stronger you stay in ketosis, the higher levels you get, the better tumor suppressor effects that you get. So, yeah, I would use them to the extent where I was pretty much constantly from the time I wake up keeping my ketones more or less artificially elevated. Well, I guess it wouldn't be artificial if you're adding MCTs, but which are a good carrier for the other forms of exogenous ketones to keep it further boosted an additional one to two millimolar. Minimum.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“I would do twice a day. It's probably twice a day or maybe three times a day depending. See, the MCT is kind of allow you to maintain the levels up a little bit higher. But I think it's okay to not continuously provide an exogenous source of ketones, but maybe just use them when you need them, if you need a boost in energy.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, I would take a level of exogenous ketones that would put me above whatever baseline I was at between one to two millimolar. So if I'm cruising along at like 1.5, staying on a modified Atkins-like diet, I would further boost that to three or three and a half with exogenous ketogenic agents. I think the easiest could be medium change triglycerides, you know, MCT powder, which will be available soon. The keto cana product. There's some, there'll be some products coming out pretty soon, ketone salt products that'll taste really good and will be will allow you to easily achieve this.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Of cells of a gleoblastroma patient. The inner Christae, the little folds inside the mitochondria where ATP is actually produced is completely screwed up and they're also deficient in various ketolytic enzymes that would allow the cancer cells to make energy from ketones. So ketones as a source of energy is a very poor energy source for cancer. So putting our state into a state of nutritional ketosis would be a way to marginalize the fuel source to ketones and enhance the energy capacity of our healthy cells. So exogenous ketones”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“It would be dinner. Yeah, you would eat probably within a window of four hours. And I think, and I've experimented with that, and that's possible. I just like eating though. So I like sitting down and having a social breakfast. And I don't eat during the day. And then I have a nice sit-down social kind of dinner at night. So I like that. So either way, I think ideally I would probably do one meal a day. And ketone supplementation, I think. I mean, we've shown independent of even the ketogenic diet that ketones have an anti-cancer effect. They not only do our ketones cannot be utilized as an energy source by aggressive cancer cells that have defective mitochondria. So cancer cells cannot use ketones effectively as an energy source because they have defective mitochondria structurally. They're defective. If you look at the mitochondria,”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“So, the ketogenic diet would be kind of a base, and instead of the normal three-day or three times a day eating pattern, I would go to an intermittent fasting personally. And I think that would be that would, you could further harness the power of ketosis by fasting throughout the day and then having a ketogenic meal. So you'd have once a day.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“So it's almost if we do a study with glioblastoma patients, it's almost like you have historical controls that you can refer to. So the ketogenic diet, I think, would be absolutely like your base therapy, right? And it would be not just a macronutrient ratio. It would be the sources of the macronutrients itself. Like you would have to, you would do a macronutrient ratio that would put you in ketosis, but take extra care to get fish that was from a natural source or grass-fed beef. And I think these things would probably be important because we know the fatty acid composition changes dramatically from a corn-fed cow to a grass-fed or a salmon that's farm raised or wild.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Okay, well, you know, so I'm not the kind of person, some of my colleagues are kind of very anti-standard of care, some of them for some ways, but I think you have to, I know you told me not to talk about chemo, but if you have something like testicular cancer or leukemia or lymphoma, there's a variety of cancer, you'd be crazy not to do the standard of care. So when I talk about this, it could, one could potentially use it as a standalone therapy, or one could use it as a way to further augment the efficacy of standard care, which we plan to do with. In some ways, it's a really good model to look at because your survival time is like one year, give or take a few months.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“about fifty percent longer and about forty five to fifty percent longer survival time. So instead of living 21 days, they live like almost 40 days. So what we're doing now, and so we have to tediously test all these things in isolation, and then we have to do different dose ranges too, right? So we got to do a variety of dose ranges and make all these dose curves and everything. But I just want to jump right into it. I want to do a calorie restricted ketogenic diet with ketone supplementation and metformin and hyperbaric oxygen. Yeah, I want to jump right to it. And we're kind of doing some of these things as pilots, but we're testing. I think it's really important to get a handle on what each of these things do at different dosages. No, definitely.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“The animal succumbs to the tumor burden within about twenty one days. So we can test and basically test a lot of things really fast because the tumors grow so fast within 21 days we have to put the animal down because it'll succumb to the tumor burn. So it allows us to test various drugs and diets and ketogenic agents. And when we tested metformin with a standard high carbohydrate rat chow and we formulated it into the food so it would be equivalent to a person taking about 2.5 grams a day. So metformin comes in like 500 milligram tablets. I think even sometimes one gram tablets. So with the 500 milligram tablets it would be taking like five tablets a day would be the human equivalent to that. The animals lived”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“And this is a model that was generated by Thomas Safred from Boston College. He wrote the book Cancer as a metabolic disease. It's a really, really good book. It's like required reading for all my students. But he developed this model and made the cover of international journal cancer. And it's probably the best model out there. So it's why we chose the model. But it's a model of advancement aesthetic cancer and the primary tumor was had a glial ballastoma kind of cell type to it. And these cells were kind of described as tumor-associated macrophages. So they can travel along blood vessels. They can metastasize to organs very aggressively. And it makes it a convenient model to use because when you implant the cells, the experiment goes real fast, right?”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“To all the organs and even the brain. So typically a glioblastoma is thought not to metastize to other organs of the body and it stays in the brain. But I think we don't typically see people with glial blastoma with liver cancer because they die of the glioblastoma before it metastasizes. So we've basically”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, so it's interesting. So the metastatic cancer model that we have, the primary tumor is derived from a tumor that pathologists confirmed was a glioblastoma. What's interesting about these cancer cells are so aggressive that we have them in culture, right? We have isolated cell cultures of these cells that are metastatic and very aggressive. And they're transfected with a gene that makes the protein luciferase. So it basically makes the cells glow in the presence of luciferin. So not to get too complicated. But if we take these cells in culture, right, we harvest them and we implant them inside the flank of the animal or underneath the skin. The cells metasize.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, yeah. It's just form into a standard diet increases the survival times of animals that have metastatic cancer. We've presented this at several meetings and we're finishing up the data now to publish it, which would be published pretty soon.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“We have a pretty good understanding of what it does and what it doesn't do. And in our metastatic cancer model, we have survival times increased almost 40 to 50 percent increase in survival. We have to have a pretty big dose.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“1.5 grams a day. I was kind of measuring out with a powdered version. So it was at least one gram a day I was taking. So that's my experience with it. And I know a few people out there. If cancer runs in your family and you are concerned that you may be at risk or maybe had cancer in the past, I think it's a pretty safe drug to take. One of my students is PhD student in his entire PhD dissertation is on Metformin. So we're looking at it very deep kind of understanding of Metformin as much as you can in a PhD dissertation. So we delve over the literature, we're running studies in individual cells in isolation in advanced cancer models.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“And yeah, I did that for three months, and I tried to take nothing else at the time or wasn't experimenting with any other things. And I took that, and my testosterone went down. But my other market, like my triglycerides were the lowest ever, my HDL was like 98. It bumped up from like 80 to 98. And other things, like my C-reactive protein wasn't even measurable. And I tried not to calorie restrict or even change my diet at all. So some things went in the positive direction, but I really thought that it suppressed my testosterone. And there was a couple of publications that would indicate that it does that. You know, maybe if I took 500 grams a day, it wouldn't, or 500 milligrams a day, I wouldn't have that effect. But I felt like at a gram a day, and I had like a powdered version, so it was probably like 1.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Not the MCT effect. Not what I describe as the MCT effect, but it's kind of like a dull kind of aching feeling in the stomach. But yeah, it was like a loose stools a little bit. And then I just kind of the next day I backed off and I played around with it for probably two or three weeks. And then I realized, okay, one gram is about what I can do, you know, safely and comfortably, I thought.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Now I didn't, and I well, I felt I don't know how to describe it, a little maybe a little less anxious, a little bit kind of like you're you kind of set the governor. Like my highs weren't as high and like, and I would kind of dose it dose it twice a day and my bigger dose would be at night time before I went to bed because that would be my bigger meal. So it would kind of dose the metapform in according to my food intake, which I think is important. But I didn't really notice any side effects. I went up to two grams a day initially and found out, okay, that's about my tolerance to it. So I backed down.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Was that my testosterone was lower? So I think that's the side effect. I have since got off of it and I recheck in my testosterone levels are back into the normal range. Did you feel that's the only thing I...”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“We know what it does and what it doesn't do. We don't really, the cancer, there's a lot of research in cancer right now. And when you go to a cancer conference, you hear there's a lot of discussion, a lot of buzz about metformin, but there's also a lot of debate as to how it's working. So some people think it's toxic to the mitochondria and it's inhibiting complex one of the mitochondria and other people are saying it works purely by activating amp kinase and other people by its ability to regulate hepatic glucose output or combination in some people through other mechanisms. So we don't know how it works, but I think I did a run where I took one gram of netformin for, I think it was 12 weeks, and I got blood work. And the only thing I...”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, you can use it for a variety of reasons. You could use it as kind of a metabolic prophylactance to prevent you from getting type 2 diabetes down the road. But when it comes to cancer, yeah, it definitely activates or dampens or activates signaling pathways associated with cancer growth and proliferation. And if you're activating amp kinase, which it's well known to do that and activate various downstream signaling processes, it mimics in many ways calorie restriction and fasting that the same processes that would be activated. It comes with some side effects and some people have intolerance to it, GI issues with it. But overall, it's a really safe drug. I mean, so many prescriptions have been written for it.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Postdoc. I was totally into working out a nutrition and understanding different diets and trying lots of stuff on myself. It allowed me to kind of come full circle and incorporate nutrition research into my research now. So our entire research program is really based on the ketogenic diet. So we do ketogenic diet studies, exogenous ketones, but we also do metabolic drugs. So we do metformin and a few other drugs.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“But then when I discovered the ketogenic diet and I wasn't really excited when I first discovered it, I was like, let me see the research on this. There's a lot of things out there. But the research on it was so cut and dry. I mean, there was an overwhelming amount of scientific research showing the efficacy of the ketogenic diet for drug-resistant pediatric seizures and now in adults too. And I realized, wow, this is like the most powerful metabolic therapy out there for seizures, like bar none. And I was like, you know, I realized this was grossly underutilized. And if I could harness the power of this and apply it to something as esoteric as CNS oxygen toxicity, that would be really cool. So I could kind of bring back my passion for nutrition, which was always there. I always even, you know, throughout grad school.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Program, it was neuroscience because I was really fascinated with the brain, but also did physiology. And I studied the neural control of autonomic regulations, so how the brain controls our body, our physiology. And then I started, did my postdoc in Looking at physiological resilience and the oxygen toxicity thing, and it brought me back full circle because when I started, you know, basically a pharmacologist as a neuroscientist trying to find a drug that would mitigate oxygen toxicity seizures. And I'm looking at all these drugs. And I realize that they're not very good. They would be good if you give them at a dose that would sedate a warfighter, you know, and basically put them into a coma and it's not very...”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“You know, as an undergrad, I enthusiastically went into a nutrition science program at Rutgers University. And my who would you call it, I guess my guidance counselor at the time, you know, just wasn't a very interesting person. And I was like, well, I kept going to her. And I said, well, direct me to labs that are doing interesting nutrition science research. There wasn't a whole lot going on. I mean, I like Rutgers and everything, but there just wasn't a whole lot of stuff going on there that really interested me. And the more people I talked to, I was kind of going the pre-route. And people were like, well, yeah, you should probably major in biology too. So I double majored in nutrition, biological sciences. But I really had a passion for nutrition. And then when I went into a PhD,”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, IGF1 is great for growing your skin and your organs. So it has a pretty global systemic anabolic effect. Whereas, and we didn't, we haven't proven this yet, but I think just based on literature, we're really.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“There that would say, well, if you give leucine, you're just going to drive cancer because you're stimulating an anabolic process that can drive cancer growth and proliferation. But I would kind of argue that that's not the case here. We definitely don't see it in this model and some of the other studies out there do not show that branch-chained amino acids cause cancer to grow faster. And some of it shows the opposite, actually. But I think branched-chain amino acids have their effect on anabolic processes are relatively specific to skeletal muscle. And I think that's really important to understand is that stimulating anabolic processes is not a global effect. It's kind of similar to anabolic steroids, right? So there's specific Receptors on the muscles. We think that the”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“We looked at survival of mice with advanced metastatic cancer and adding the branched-chain amino acid to the ketogenic diet, we had like a 50% increase in survival with the ketogenic diet alone. And when we added branched gene amino acids to the ketogenic diet, there was trends for an increase in survival. But I think the big thing is that we saw the animals were maintaining their weight better with the branching amino acids added to it. So with branched chain amino acids, one of them is leucine, and we know leucine can activate mtor. MTOR has been associated with driving, a major driver for cancer growth and proliferation. But, you know, and there's cancer biologists out there.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT
“That we want to metabolically starve cancer cells in our experiment and preserve muscle at the same time. So the extend product that's out there by station is a remarkable product. I think people like it because it tastes so good. So the people who formulate the product really know what they're doing with taste. So it tastes like really, really good. And that's if you want a successful product, it doesn't matter if it, you know, cures cancer, enhances your performance 10 times over. If it doesn't taste good, people are not going to take it. So the sivation branching amino acids, they taste really good, but they're also very tolerable and very palatable. But this particular product had glutamine. So we removed it from the formula for our studies and we ran a study with a ketogenic diet and we added the branch chain amino acid to the ketogenic diet.”
2015-11-03 · The Tim Ferriss Show · #117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer · IDENTIFIED FROM THE TRANSCRIPT