YouSaid · the spoken record

Dr. Dominic D'Agostino

lines on the record: 110
first: 2026-01-07
most recent: 2026-01-07
sittings or episodes: 1
sources: podcast

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“Customers recommend Gusto. Listeners get three months free once they run their first payroll. Again, that's GUSTO.com slash Tim. Terms and Conditions Apply. I have been fascinated by the microbiome and probiotics as well as prebiotics for decades, but products never quite live up to the hype. Now things are starting to change, and that includes this episode sponsor, Seeds DSO1 Daily Symbiotic. I've always been very skeptical of most probiotics, but after incorporating two capsules of seeds DSO1 into my morning routine, I have noticed improved digestion and improved overall health. So why is seeds DSO1 so effective? For one, it is a two-in-one probiotic and prebiotic formulated with 24 clinically and scientifically studied strains. But if the probiotic strains don't make it to the right place, they are not as effective. So Seed developed a proprietary capsule and capsule delivery system that survives digestion and delivers a precision release of the live and viable probiotics to the colon. And now you can get 20% off your first month with code 2010.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“I asked millions of you about Gusto on social media, and I've never seen such overwhelmingly positive responses. It was kind of bonkers, honestly, because I've done this dozens of times. And it makes sense. More than 400,000 small businesses already trust Gusto, and it's been named the number one payroll software by G2 for fall 2025. If you're a small business owner looking to simplify payroll and HR tasks, because why would you want to spend more time on those things, Gusto could be the game changer that you need. Gusto is the all-in-one payroll benefits and HR platform designed specifically for small businesses. They automatically file federal, state, and local payroll taxes, handle W2s and 1099s. What a pain in the ass all those can be, and offer straightforward health benefits and 401k options for nearly any budget. Now is the perfect time to choose Gusto to take care of your team and stay compliant. So go to gusto.com slash tim to see why nine out of 10 gusto”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Off for the weekend, something to think about. If you'd like to try it out, just go to tim.blog slash Friday, type that into your browser, tim.blog slash Friday, drop in your email and you'll get the very next one. Thanks for listening.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Hey guys, this is Tim again. Just one more thing before you take off, and that is Five Bullet Friday. Would you enjoy getting a short email from me every Friday that provides a little fun before the weekend? Between one and a half and two million people subscribe to my free newsletter, my super short newsletter called Five Bullet Friday. Easy to sign up, easy to cancel. It is basically a half page that I send out every Friday to share the coolest things I've found or discovered or have started exploring over that week. It's kind of like my diary of cool things. It often includes articles I'm reading, books I'm reading, albums perhaps, gadgets, gizmos, all sorts of tech tricks and so on that get sent to me by my friends, including a lot of podcast guests and these strange esoteric things end up in my field and then I test them and then I share them with you. So if that sounds fun, again, it's very short, a little tiny bite of goodness before you head.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, and everybody, as per always, thanks for tuning in. And until next time, be just a bit kinder to others and also to yourself, especially if you might be self-flagellating yourself over not hitting your GKIs like yours truly. All right, take care, everybody.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Beautiful. We will link to all those things for people listening as well as God save the people who help me do the show notes. They're going to have a lot to dig through. But we will link to everything that we can find a link for at tim.blog slash podcast. Just search Dominic. And this will be the most recent episode. I mean, we may have some in the future. So you'll find it. And Dom, thank you so much for taking the time and always great to see you.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Beautiful. Well, trying to think of any other links. Are there any other links that you want to mention? And we'll stick these all in the show notes as well for people.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“I mean, look, I mean, they could take the approach that a lot of companies take, a lot of tech startups take, like Uber, Tesla, et cetera. You sell in the beginning for much higher price to people who are willing to pay that. You use that to subsidize the R&D or the scale necessary to then offer, right, instead of Uber Black, you have Uber X. And similarly for a lot of companies, I would pay for this, right? And I'm, yeah, I wouldn't say totally price insensitive, but I'm willing to pay for convenience because there does come a point where I've had enough canned mackerel and salads with ribeye that I would love to have something else. In any case, so I will check out Medi Foods. Let's see. Dom, are you active on social anywhere? Should people find you anywhere online?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, Dom, is there anything else you would like to mention or anywhere you'd like to point people before we wind this to a close?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Wow, dosed the wrong guy or the right guy because you imagine like what if that had been a 80 year old woman sleeping on the second floor? I mean.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“People are going to assume when people hear gummies, they assume it's THC. But this was what theanine and magnesium? It should have been really innocuous, right? Is that right”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, good body composition. That is a lot of muscle for people who are not watching the video. I'm just trying to set the maybe context for what your tolerance might be for grams of carbohydrates.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“How much can you eat of apples or berries before undoing all the good metabolic work that you're doing in ketosis, right? Because even, for instance, we've talked about how easy it is and it really is easy as long as you're pretty simple to please dietarily to say travel for keto, right? So you just pack a bunch of canned sardines, mackerel, maybe some oysters and macadamia nuts and like you're kind of good to go. Like these things are pretty calorically dense. But the macadamia nuts, right? I was looking at the bag the other day because it's one of the few kind of crunchy things that I feel like I can eat aside from some of these vegetables. And I was like, wow, like you can, if you go a whole hog on the macadamia nuts, like you can rack up the carbs after a while. What about apples and berries? Like how much, where's your cutoff point for yourself?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Now, wild blueberries, this one are really underline wild for people because that is not what you're necessarily going to get at your local grocery store that's been optimized to be as sweet as possible.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Helpful for slowing, I guess, gastric emptying of these meals that I'm having. And I'm curious for you on a ketogenic diet, what are your favorite sources of fiber, supplemental or in whole food form”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“So, I know as I'm watching, things get dark on the East Coast for you that we'll wrap up in just a few minutes. But in brief, you mentioned fat salt fiber as things that can”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“And Vitch was the co-inventor, is that fair to say, of the bonded monoester that was funded in part by, was it the DoD or DARPA and then patented at Oxford? Is that right? Am I getting my facts straight? Or am I getting things mixed up?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Patrick Arnold. So people who don't recognize Patrick, listen to my conversation with him from years ago. But if you know Balco or remember when Barry Bonds grew a few head sizes or any of that stuff, anyway, Patrick's got some stories. So the jello shots. So, what happened with the jello shots?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Just to give a reiteration of that, the 13 butane dial based stuff is also sold as an alcohol replacement. So of course being the idiot that I am, not idiot, just like I'm eager to experiment here and there if it's not going to kill me. And so I thought, you know what? I don't want to drink tonight. This was in. I remember where I was. I was in upstate New York, about to go to a restaurant with a friend. I knew he would want to drink. And then I wanted to be able to say, hey, I already had this ahead of time. Don't worry. Like we're on the same level. And I chugged a small can. It wasn't in terms of liquid volume a lot, right? I don't know, six ounces, eight ounces. And I felt like I could barely walk to the bathroom. Like I was smashed. It was like almost knocked the glass off the table. I was like, holy shit, I did not do this risk assessment properly. Like, thank God I'm not about to get into a car because it took a little while to wear off.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“What are the symptoms of that? I mean, imagining you don't get like DT, right? You're not getting shakes or anything, are you? But, I mean, like, what happens?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Less of a priority, right, than it once was after shoulder surgeries and elbow surgeries and various things. Not that I want to be the skinniest guy in the room, but okay, it sounds like the pharmacokinetics are maybe to blame with the associated spike in insulin for some of the issues you might run into if you're taking the 1-3-butane dial based products.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“That's the thing, right? I would say that for 15 years, right, the sort of 30 grams within 30 minutes of waking up has been this sort of easy to remember heuristic that I've recommended for folks and that if I am not intermittent fasting, that's also what I do. But I've become so addicted to the mental sharpness that it's just like, man, I know that if, for instance, if I want to do three hours of writing, I do not want to have food immediately prior to that. But I would say if I'm also at a point, I think where thrown up really heavy weight and for me and getting as big and strong as possible is just not.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Asked you is there any argument to be made that I should have a ketogenic breakfast instead of intermittent fasting? Could it be that I'm causing problems with exogenous ketones? Am I delaying potentially the onset of my own ketosis? Is it like TRT, right? If you're taking exogenous, remember that word, if you're injecting or rubbing on or swallowing testosterone, it's like your Lideig cells are pretty smart. That's the reason your balls turn into raisin nets is because it's like, cool, we don't have to make that anymore. So I thought, am I shooting myself in the foot by taking exogenous ketones? And it sounds like a little bit goes a long way, but like most things, in excess, it kind of becomes its opposite, right? It becomes a hindrance and makes it problematic. Is that fair to say?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“You know, of all the disgusting things that I have consumed in my life and I've had a lot, right? I mean, I've tried early prototypes of some of the esters and like all sorts of stuff. I'm not going to say it was a pina colada, but I was fine with it. MCT oil to this day, I just find so absolutely revolting. I don't know if it's the neutrality and the mouthfeel, but mixed with the mackerel and that apple cider vinegar, it sounds so disgusting. My friend almost puked in his mouth yesterday when I was describing it. It's actually really good. I'm just a sucker for mackerel. I'll take mackerel over sardines all day long. But let's see here. So I think we've covered a lot of the exogenous ketones. I'll just pull this from our text thread because I think it might be a question on some people's minds. As I was trying to troubleshoot my apparent failure mode with ketosis because of my low numbers, I”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Although it's not that much though, right? I mean, because 30 milliliters is like two tablespoons. Is that roughly right? So it's like six tablespoons. If you're just squirting it into your coffee, like it's not hard. Necessarily get above 100. It's actually pretty easy. So, where would you recommend capping MCT consumption? I'll get rid of my camel back with the MCT oil in it, but where would you recommend capping?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“How does the MCT oil help? I guess basically it makes the ramp up more gradual is that the effect that these sort of co-consumption of the MCT oil has?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Saying in any way, but your wife runs a company that sells ketone salts, which I also have been using most consistently, keto starter people can check it out. But on the ketone monoester, what I'm wondering is if I'm only taking, let's say, 11 milliliters once or twice a day, I'm taking it alongside MCT oil, where would you put the kind of risk analysis on something like that?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“The first one or two times. I will say for folks, if at first you don't succeed, meaning you have to run to the toilet, you may acclimate to it, which I did in that case, but I felt subjectively less and less effect. I seemed to develop tolerance very quickly. I don't know why that would be the case, but I seem to experience it. The ketone monoester, which is the 1-3-butane diol bound to BHP, if I understand it correctly, right? I do like that. I like the subjective feeling of it, but if that's only at about 11 milliliters, if I take 25 plus speaking to your pharmacokinetics, right, like the stock pops and then it drops, and then I feel very tired and often feel more anxiety. It seems to prompt in me more anxiety. So I guess my question is, and then we got to talk about this. Not that it invalidates what you're saying.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“GKI. But that's a story for another time. Only in the things that only Tom would do category that stand out. But we're talking about a lot of terms that are likely unfamiliar to folks. I don't want to throw anybody under the bus here, but people should do their homework. 1-3-butane dial is very, very, very common. It's very inexpensive, relatively inexpensive to produce. So just keep an eye out for one, three butene dial. If this is of interest to you, I have no investment in any ketone supplement company or anything. I do not have a stake in this. But what I would love to ask, I would like to ask a couple things. So I have experimented, as you know, with ketone, monoester, diester, ketone salts. I've kind of played with everything. And I found the diester to cause quite a bit of intestinal discomfort, to put it mildly at least.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“The hounds, yeah, out there, hopefully about next to the gators. We won't spend any time on this, but I just wanted to tell people that before we started recording, you're telling me that you caught a 10-foot alligator that was trying to eat your dogs. And then you pinned it down, taped its mouth, and then measured its glucose and ketones. Turns out that alligator had a pretty good.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“So transaminases are what people could think of as liver enzymes on their blood panels, right? AST ALT. Is GGT typically tested?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“How would you translate? Can you translate from the animal models to humans, do you think, because we all know humans are not just big furry mice, right? Do you think it translates? I mean, and this might be just like a precautionary measure where it's like, well, pending additional studies, let's hit pause in a sense. If it were to translate, do you have any idea what type of dosing per day or per week with which we might see this toxicity in humans?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“For the time being, not talk about the acute medical delivery. Let's talk about recreational slash better said layperson use. This is as a dietary supplement. Could you speak to the toxicity piece?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Supplemental ketones. And are there any warnings or disclaimers that you want to add to that? Because this is a topic du jour. I think there's probably no biological free lunch if people are going to be mainlining fruity pebbles and eating tons of carbohydrates, maybe not a great idea to eat tons of exogenous ketones. I don't know. I'd be curious to get your take on that. What's the good, the bad, and the ugly of exogenous ketones? Where should people go? How should they think about it?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Time to completion for four bouts, like modules of tasks has just gone up and up and up since I've sort of been an extended ketosis. And that's very easy for me to see. So folks who are listening, I'll have more to share on that later, but it's pretty mind-blowing stuff. So Dom, you know, a few things have come up that I would love to chat about because I get these questions all the time, which relate to exogenous ketones. And people have heard this term exogenous endogenous. It's very fancy talk in a tuxedo for outside the body, in the body, right? I'm simplifying here. But the easy way to remember exogenous is exoskeleton, right? It's like a skeleton on the outside of your body. Exogenous ketones. Ketones that you are taking from outside and putting inside. People always ask, and I know you kind of have a dog in the fight here, so I want to recognize that too. But how should people think about”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“I'm actually, I have time blocked out in my calendar this Friday to do a whole battery of cognitive testing. And I've also, I will say, and again, this is not super precise, but having tracked myself for so long and developed a water feel for certain types of performance, zone two feels a lot easier right now, a lot easier than usual. And coming back to your prior comments. And then I would say I'm using software right now. At some point, I'll be able to talk more about this, but to basically train my visual processing to compensate for Presbyopia, it is crazy some of the effects that this stuff has. But it also is very much indirectly a measure of reaction speed. And they see some really cool carryover effects. And my speed in terms of”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“There's just, there doesn't seem to be a physiological option C for failure, right? It's like, what's my body going to do? Like it has to be doing something. I'm not getting the dietary carbohydrate and I'm not just mainlining whey protein isolate all day. I think I'll probably just have to kind of trust in the process because if I do have the increased ketone utilization and I'm just somewhere between 0.2 and 0.4 millimolars for the most part, I just don't think the math might be really hard even to hit the GKI of four. But it's like if you're following the process, I guess you're following the process. Right. I say.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Never had this experience in ketosis before where these levels have been this low. It's so bizarre. And yet, let's say back in the day, before the intermittent fasting, and it's pretty much the lever that I pulled that I think changed things. Prior to that, I could tell you probably within 60 minutes of hitting 0.7 millimolars on the precision extra. Like I knew when my brain clicked past that point. I did years and years and years of this stuff. So I think as much as I like to measure things, I should just assume, right, if I'm having a bowl of mackerel dog food with MCT oil and apple cider vinegar and salt and pepper, then having a meal later that effectively has close to zero carbohydrates. If I'm doing that for almost three weeks.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Whether it's on paper or otherwise, account for the increased ketone utilization. I mean, it'd be great for me just to verify that somehow. But then whether I can verify it or not, if I wanted to try to determine during that week, like if I'm hitting my target GKI, how would you suggest that someone like me do that if I'm just not getting the numbers necessary to make the regular math work?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“The GKI. Oh, you know what? I do have the GKI because you're right, the keto mojo also measures glucose. I guess what I'm asking for myself is since my readouts are so low, presumably as a placeholder due to improved insulin sensitivity and ketone utilization, I'm going to fail, right? If I'm just using the glucose and the ketone strips for the ketone mojo because right now, if it's telling me that I'm at 0.4 millimolars. And I can tell you subjectively, I do not feel like I'm at 0.4. I feel like I've got a lot more juice and a lot more gas in the tank. Is there a way to”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“GKI sweet spot. So, how would you suggest I try to figure that out? Is there a way to measure my ketone uptake and therefore modify the equation such that I factor that in somehow? There's a multiplier of the readout on the fingerprint or something like that. How would you handle that?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, so look, I think I'm probably saying what I wish to be true, which is that my insulin sensitivity has improved a lot in the last certainly year in particular. And that is to explain in part the or maybe wholly the lower readout on the ketone meters. But part of the reason I have confidence in that is that I'm using the same devices that I used to use. And back in the day, I would have much higher millimolar readouts. Of course, I have new strips. I did, at least to the extent that I can for the continuous monitors. I've done calibration for the CGM at least, the glucose monitor. But that presents a problem, even if that is good news, Tim Ferris, you're not failing at keto. You've actually just made yourself a lot healthier with intermittent fasting and other things. It still presents a problem for me to figure out if I am in that.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Look like in terms of the readout on the glucometer and the readout on the fingerprint for the millimolars for ketones. What would be an example?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“You mentioned people can find calculators out there, and actually a lot of the devices will try to provide this to you. Actually, is that true? I guess they would have to have both data streams. So probably not, but the GKI. So the glucose ketone index, you can find calculators for this, but fact-check this since this is AI overview from Google. I wanted to just take a look at it. Divide your blood glucose level by your ketone level. If your glucose is milligrams per deciliter, common in the US, you first divide it by 18. This is an important step to convert it to millimolars per liter matching the ketone units and then perform the division. So you can figure this out very easily. And that is the GKI that you are mentioning of a one to two. What might that look like just offhand? I'm very not known for my quick mental arithmetic on the podcast, but what would a GKI of say one or two?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“So, for you personally, if you had some hereditary gnarliness, right, if you look back at your family tree and you're like, ooh, whether it's a bunch of cancer or a bunch of neurodegenerative stuff, maybe a bit of both, who knows? Would you be more inclined to do the one week per month just for you personally?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“I'm just thinking about the lead time to get into a properly ketogenic state if I'm going from some carbohydrate to ketosis. I'm just, we could talk about things that might accelerate it, but like if it takes me two days to get there or three days and then I only have kind of four days in the sweet spot. These are things running through my mind. I'm just curious to get your take.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Every three months or three weeks, three contiguous weeks, once a quarter. Do you feel like one of those is superior to the other”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Probably fair to say make sure you consistently hydrate for any of these things like a Dexas scan. I do have a follow-up question. So also on the exercise piece, people can look up something called Clotho, K-L-O-T-H-O. There's a lot more that comes with exercise, like BDNF and all these various things. There's a book called Spark that covers some of it, but it's very outdated. But check out Clotho. There are a lot of good reasons to exercise thinking of muscle like an endricon organ. That's a really good way to put it. My question to you was, you mentioned, say, one week per month going to more of a lower carb or ketotic state. How do you think about the benefits of one week per month, assuming that the rest of the time I'm behaving most of the time? With a lower carbohydrate Mediterranean diet, let's just say, okay, one week per month.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Kills everybody in my family. So for a lot of reasons, I don't want to do keto all year, but I'm trying to figure out what is the sort of minimal effective dose that, and I know we're going to have to probably take a couple of speculative leaps here, but just as a working hypothesis, right? Like what does a minimum effective dose of following a strict ketogenic diet look like for me? Assuming the rest of the time, I'm still doing intermittent fasting. I'm not eating a lot of refined carbohydrates. But how might you suggest that I think about that, right? Because I don't know what the durability of kind of keto memory, like metabolic memory is. So I'm trying to figure out like, can I get away with two three to four week periods a year where there's some carryover of like cancer protective, you know, our last conversation we kind of talked about, thinking about ketones as hormones. But in terms of neuroprotective, anti-inflammatory,”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“To see. But I guess I'm laying this all in not necessarily to explore this particular case because I've got a lot of people on it for all of my relatives. But it's just to say that I am not going quietly into the night with something like Alzheimer's. And so what I'm trying to figure out for myself, I'd be curious to hear your perspective. I will be honest. I find keto pretty goddamn boring. Like I don't find it to be the most diverse diet in the world. I don't really want to do it all year round. I also have some maybe compromising cardiac elements. I'm a cholesterol hyperabsorber. So I do use, again, guys, talk to your doc. Don't just copy me, but it's like I'm using Repatha taking a Zetamibe. I have been also taking NexoZet, but that might end up being redundant, the Bempadoic acid with the Repatha. That is a long way of saying, like, I got to keep an eye on the hard stuff because neurodegenerative disease and cardiovascular disease is what's”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT