YouSaid · the spoken record

Dr. Dominic D'Agostino

lines on the record: 110
first: 2026-01-07
most recent: 2026-01-07
sittings or episodes: 1
sources: podcast

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“Okay. Yeah, guys, too. Yeah, yeah. So I was looking at it and I mean, it's upsetting that I'm the one who has to kind of find these things, but it's like, okay, well, we think about the oncologist's role. It's to prevent my mom from dying of cancer. That's the directive, right? But if she were 30 and had later stage cancer that was really aggressive, it's one thing. But she's late 70s, stage one, all cancer removed. And so got her off of the letrizole with the cooperation. And after discussions with doctors and almost saw an immediate turnaround within a handful of weeks after the washout period and everything. But it seems to, I mean, look, I'm not an MD. I don't play one on the internet, but it seems to have done some real damage. I mean, there's the metabolic piece that is very nontrivial, but the acceleration of decline was just so absurd over the course of a handful of months.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“I mean, poorer body composition. Yeah. Poor body composition, very little exercise, despite my best efforts, misbehaves horribly, dietarily, not morbidly obese, but certainly No smoking or alcohol. But here's the other piece. So she had been diagnosed, stage one breast cancer, had a lumpectomy, was removed late 70s was put on an estrogen, I think it's an estrogen blocker called letrizole. And I looked at this and I spoke to a friend of mine who was a radio oncologist and she said it is very poorly tolerated by most women from a cognitive perspective. Like they get smashed by and large.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Patient data or clinical data that a number of doctors who are also researchers I was working with had seen. Also because this person, this relative had been assessed four or five years prior and did not show any indication of predisposition to a rapid decline. I'm ABOE34 again recognizing there are other factors at play. But when she just kind of disintegrated, there are a few things that came to light. Number one is her local GP had basically missed severe metabolic dysfunction for years. And I can't remember the reference range, but like insulin, let's call it upper bound of 12. I'm making this up. But you'll get the idea. And she was like 43, right? It was just absolutely atrocious.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Mean the metabolic health piece just to underscore that. I mean, one of my relatives in question, ABOE33, I understand that's not the only risk factor, but something just seemed to be missing, right? Because the decline was so precipitous. It didn't map to any”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, I need side bio if you're listening. Please allow me to calibrate this with a fingerprint because I need a little more range. I need a little more range than 0.01 to 0.04 for me to be able to read this type of thing effectively, right? Because technically, if I'm going to believe if I'm reading this as it is, like I'm never in ketosis, I shouldn't say never. That's not true. In any case, it would be nice to be able to calibrate. Come back to something I promised that I would ask about which is neurodegenerative disease, Alzheimer's, et cetera. Could the ketogenic diet benefit people with these conditions? And just as important, certainly for me personally, is it plausible there's a mechanism by which the ketogenic diet regularly done could help delay the onset of any of”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“All right, so 3600 calories, that's a decent amount of calories, right? And for somebody who's, let's just say you're 150 pounds, 10% body fat, okay, you got 15 times 3,600, you got plenty of body fat to go around. So it would seem to be enough to do a few weeks of ketosis that is low fat, higher protein, but not enough protein to necessarily be hammering your liver with gluco neogenesis if you're dividing it up slowly digested protein. Some people are going to be really annoyed with me dragging this out so long. But why is dietary fat so important?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“I don't want to beat this dead horse too long, but I'd love to just hear you riff on this a little bit more because I guess in my mind I'm thinking, well, on your protein veggie only days, if you're getting enough protein, not enough protein to satisfy all of your resting metabolic rate, your hypo-caloric, but you're getting enough protein to not lose muscle. Why wouldn't the body just break down the fat that it needs to continue producing ketones? So I'm trying to avoid the glucogenesis problem where you're having like 200 grams at a meal with no fat to offset it. But if you're having smaller amounts that are slowly digested, but it's just enough to keep you from losing muscle mass, maybe you're doing some weight training to help with that or whatever, then I guess what I'm trying to figure out is why the dietary fat is so important.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“That's my understanding. Maybe there's a rate limiting step in how much body fat you can break down and use, right? And who knows if that's mediated by the kidneys or who the hell liver, I don't know, right? I guess it would probably be liver. I'd love to hear your take on it because certainly in the past I and lots of people reading the four-hour body have been able to lose more body fat than they're told they are capable of losing as measured through DEXA scans and other things. Can you do a moderate fat or low fat protein based keto diet if your goal in part is to lose body fat or does that backfire?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Season six and seven in particular are outstanding for folks. But what you will notice is that if people are trying to survive in the wilderness to outlast everyone else, that's what the show is. You get to pick a handful of items, you get dropped off, you don't get to choose where you're dropped, and then you just need to survive for as long as possible. Sometimes it's 100 days, sometimes it's last man or woman standing. If somebody is only eating lean protein like rabbits, they will waste away. They will not last. They will have to get yanked out for medical reasons. And that might seem strange to people. My question, though, is on a ketogenic diet specifically, can you just consume leaner protein and then rely on body fat for the fat? And some people are like, yeah, everybody knows that doesn't work. But I really want to understand why that's the case, right? Because I understand dietary fat sort of dampens insulin response.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“I'll go out and have another meal probably in like three or four hours, which will be a much bigger meal. And just with that, and I am watching some of the grams of protein intake and so on, but I have not, looking in the mirror and looking at the weights that I'm putting up in the gym, I don't feel like I have lost any muscle. And I feel like I have leaned out. Some of that's losing fluid. But I've been really impressed with how little relative to what I used to do in college, like taking weight gainers and just all this garbage, like how little it actually takes to at least maintain muscle mass. But I do have a question for you, which I've never really been able to answer to my satisfaction. And it kind of relates to rabbit starvation. So for people who don't know what that is, you could probably give a better description. But if you've ever watched the show alone, alone is probably the only reality TV show that I love to watch.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Let me hop in also and just tell folks this is not going to be very quantifiable, but for what it's worth, part of my reason I avoided intermittent fasting for so long is that I thought I would not be able to get sufficient protein or caloric intake and that I would lose a bunch of muscle mass. I was dead wrong about that. I was very, very wrong. If anything, it seems to have enhanced my ability to put on muscle kind of per calorie or program of protein ingested. So I admit I was totally wrong about that. Furthermore, on this ketogenic diet where I've historically found it pretty hard to put on muscle or maybe I shouldn't say keep muscle because I'm only doing it for a few weeks. But I have been astonished by having one small meal. Like I'll have some oxtail soup after this with some veggies and obviously oxtail. It's a whole separate story. And then”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“I inputted one measurement on the Keto Mojo and it didn't seem to change it. The numbers stayed the same. So I think it's just logging it because you can do that with a glucometer.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“They do have in events, they have blood ketone on the bottom right. I don't know if it actually calibrates it. It may just record the blood ketone at this point.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Would give me an extra 0.1 or 2, but they've been pretty close so far. And then ever since my cheat meal, we had this experiment, right? I wanted to see if I did a workout and then had one or two cheat meals last Saturday. Still thinking about the size of the meal. But I guess what I'm saying is if my device is telling me as it is right now, 0.4, fat not burning, you're almost not burning fat at the moment, not in ketone. Like it's very chastising. So if I'm to believe this by the letter of the law on the screen, I'm failing at ketosis. Any thoughts on how to kind of read the tea leaves here?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Meal or I'm fasting as I am right now, my range is basically 0.1 to 0.4, 95% of the time. There are a few outlier cases. If I'm just doing like a YOLO, you know, as many grams as possible exogenous ketone party, then maybe I could goose it, but we can talk about this. Once it gets past a certain point, then I might spike insulin and like have a subsequent crash. But I guess what I'm trying to say in brief is my range for the most part is 0.1 to 0.4, regardless of whether I'm fasting or eating a gigantic double cheeseburger. So I'm not really sure how to determine what effect it's having. I can watch the glucose, but right now I'm 0.4 millimolars of concentration on the side bio. And as we've talked about, maybe the precision extra.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“All right, Glue for. Yeah, for the OGs in the audience, go back and look for Glute 4 in 4-hour body. It's in there. So the other measurement question I want to ask you about, which is, you know, these continuous glucose and keto monitors are not designed for someone like me. They're developed presumably. I don't know about the ketone monitor, but in the case of glucose to help people with serious conditions not end up in very serious situations, right? When I am looking at my ketone levels, right? Like right now, I feel very sharp. I had some keto start. You know this well. Exogenous ketone salt based product not too long ago just in hot water with a little bit of MCT oil. This was, I guess, an hour, hour and a half ago. But I'm at 0.4 millimolars. And I guess what I'm saying is whether I have a huge”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Me ask you this on the walk timing. So when I have a big meal, and I will say I think I have trained my body to have big meals and what the exact response is, I can only give you subjectively what I feel and I can give you what the monitors show. But I typically feel pretty good. However, if I have a big meal, whether this is in ketosis or otherwise, I don't see the biggest spike until something like depends on the meal, right? But 60 to 90 minutes later, that's when I see the spike. So should I do the walk at 60 to 90 minutes or should I do the walk right after the meal? When should I actually time the walk?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“So they just translate that for a second. So people wake up. The cortisol has developed this bad reputation among a lot of online influencers. But it's like, you really need cortisol. So when you wake up in the morning and you see a bit of a glucose spike, like it's actually important to get your ass up and moving. If you're in ketosis, it's a different thing, right? So if I'm hearing you correctly, right, outside of how people think about digestion Blood sugar, insulin, et cetera, that just based on stretching your stomach, et cetera, right? With these mechanoreceptors taking the inputs, that that signals to the brain, it's go time. So let's basically get things moving with these hormones. And that could in and of itself then trigger the liver to produce more glucose or liberate more glycogen, I guess.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“And so I go online to try to figure out what the protein content of this thing might be. And it's like 80 grams of protein. But plenty of fat, certainly, tons of fat, salty AF, plenty of salt, not a lot of fiber. We'll give that one a pass. Should I be worried about something like that knocking me out of ketosis?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Having a small meal around three and then a gigantic meal later on, how should I and how should listeners think about this?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Yeah. And people might have picked up when Dom was casually throwing around like, you know, when you've been squatting 400 and you take a break and then you go back and you only squat 300 pounds. Tom's a pretty big guy who's also deadlifted 500 pounds for like 10 reps before after fasting for a week. So he and I are not the same size. But nonetheless, I'm trying to figure out on one hand how much protein I can eat without my liver taking excess protein amino acids and turning it into glucose. And depending on what I look at, and I have looked at sources outside of ChatGPT, on one hand, there are folks who say, don't worry about it. If you're consuming enough fat, you really don't have to worry about it. And then there are other folks are like, watch out, watch out. If you consume more than X number of grams at a given meal, you can very easily knock yourself out of ketosis, which would, if that's true, be maybe an alternate explanation for why I'm getting these low readings.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Here's another practical question for you because I've gone back and forth on this. And Uncle Chad GPT has confused the shit out of me. So maybe you can help resolve it. Gluco neogenesis and protein intake. So you consume, what is it between like 200 grams of protein a day, something like that?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“It looks like a breathless, right? So is that measuring, what is it, acetylacetate? No, I'm just trying to repeat words that I've heard once or twice. But it's not BHB.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Afterwards. Yeah. Okay. So it sounds like then because of probably the intermittent fasting in large part, I would think, if my insulin sensitivity is high enough, that can be paired with higher ketone utilization. If I didn't have good ketone utilization and it was my first rodeo with ketosis, let's just say, or a ketogenic diet, the fingerprick might pick up all 10 of those units. I'm simplifying here, right? But if I have high ketone utilization and my body's quickly using eight of those, especially in a caloric deficit, then it's only measuring two and I'm getting the false negative that I'm not actually producing ketones in the first place. Is that a fair, very, very simplified description?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“And the OGT for folks is just that oral glucose tolerance test where you drink a bunch of dextrous water and then they take your blood every 30 minutes for two hours to see how you're responding to it.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“And 80. And my ketones were 0.2 millimolars. Now, when we've talked in prior conversations about what kind of target you might aim for, it seems like between 1.2 and 2 millimolars is anxiolytic, right? Lowers anxiety. And then you're looking for this ratio. You could talk about this, but the GKI, there's a ratio, glucose to ketones. And I look at those numbers and I'm like, this makes no sense to me because I'm not getting enough glucose to function well. And if I'm basing it off of the keto mojo fingerprint, even the precision extra from Abbott or my continuous keto monitor, I'm not getting any ketones either if you're taking it at face value. So how am I functioning? How would you answer that? Because I don't think I'd be the only person who feels.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Continuous ketone monitor on the other arm, and I'm wearing an aura ring when I sleep to see how all of this affects my sleep architecture and everything else. So I'm gathering all of this, but then I noticed something really weird, which I've texted you about because I keep feeling like I'm failing at keto. I feel great. I feel sharp. And yet when I look at not just the continuous glucose monitor, but even with the fingerprint, because you do have to often calibrate these things, right? Don't assume that your continuous monitors are accurate. You want to calibrate them. But I'm looking at the numbers. And for instance, my girlfriend freaked out the other night because my phone started screaming. I had earplugs in because I didn't hear it. And it was like critical medical alert or whatever the code read was because my glucose was 69, I suppose. It's gotten quite a bit lower on ketosis, but it usually hovers somewhere between like 60.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Creep up on you. But that is in effect the diet, right? And I'm doing my training. I'm doing my rehab. I'm doing my zone two. I do find I'm a little, let's say, lower performance when I'm in ketosis. But what I wanted to talk about is maybe a false negative that I've experienced. And I'll explain what that is. And this is, so how do you know if you're, and I keep putting this in quotation marks, like quote unquote in ketosis, right? Because people are Most people are, or maybe all people, are producing some level of ketones. So there are different concentrations, right? You can measure with a fingerprint just like you would look at glucose. And at least with the fingerprint, I think that's measuring what you mentioned earlier as being so beneficial in a lot of studies that beta hydroxybutyrate, BHB. I also have, because I wanted to run this tracking, a G7 DEXCOM continuous glucose monitor on one arm, and then a sci bio, apologies, I'm not pronouncing that correctly.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“And just for people who are like, oh my God, I can't believe you guys are eating mackerel mixed with oil and vinegar and a dog ball. That's not all you can eat. Like there's more that you can eat. You can have like chicken with cheese on it. You can have vegetables. There's certain things you have to watch out for so you're not whacking yourself out of ketosis. But in my particular case, I don't mind. And the fact of the matter is when I wrote the four-hour body, people were like, oh my God, you want us to repeat the same meals over and over again. I'm like, what did you have for breakfast the last five days? And they ate the same damn thing. You're just swapping out default meals. So my first meal is something typically pretty small, like the mackerel I explained. And then I have a big meal. I might have some more protein in between, but it's like yesterday I had lamb chops that were delicious with some vegetables made in an air fryer. No problem. And later on, I might have like a rib-eye on a big, gigantic salad with some other stuff added to it. But that's about it. You have to be careful with the macadamia nuts. Those things will...”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Maybe you could mention I'll put links in the show notes as well. Default to that you like. And that Chub mackerel piece for folks, that detail is important because they're a mackerel of many different sizes.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, for people who might think, oh, wow, this is what for fancy people who can do all sorts of expensive things in their diet, we're talking about how much does that meal cost? Three bucks? Yeah.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Frankly, pretty disgusting, but that are actually really easy, like two cans of canned mackerel with about two tablespoons, 30 milliliters of MCT oil plus apple cider vinegar with some salt and pepper. It's actually delicious. I just love mackerel. Oh, there it is. Yeah, you've got your apple cider vinegar right there.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“When I got to the point of going into the ketogenic diet this time and also a few months ago, because I was doing the intermittent fasting and it took me about a week and a half for my body to get comfortable with that, at which point it was no problem, but I was a little pissy, a little irritable for a little while, a little foggy. And then when I went into the Ketochank diet this time, it was the easiest transition I've ever had. I did not have any fogginess. I did not have low energy. I did not have what some people might call the kind of keto flu adaptive period, which seems to be pretty remediated or addressed with electrolytes for a lot of people. But it was incredibly easy just straight into the ketogenic diet with no problem because I was already doing the integrated fasting. Then for 18 days, I've been having two meals a day. And you've recommended a few that sound”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Matson, M-A-T-T-T-T-S-O-N, who's done a lot of research related to intermittent fasting. And the key piece for me, because you see all of these different types of intermittent fasting, all these different ways to do time restricted feeding. And I am going to paraphrase here. So Mark, I apologize if I'm getting this wrong or oversimplifying. But in effect, it's important that you fast. This means no calories. We could talk about pure fat, but let's just assume you're not consuming any calories for 16 hours because you want to deplete your liver of glycogen. And once you deplete your liver of glycogen, your body experiences this metabolic switching. And I've certainly felt this. Just doing intermittent fasting, where my meals contain carbohydrates later that around the end of that fasting period, boom, something switches and my mind is sharper. And then”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Okay. Yeah, metabolic memory. So just so people know where I am at the moment. Actually, yeah, I'll just tell people like what I'm doing because I know they're probably getting itchy for some just like, what does this look like in practice? And then I want to talk a bit about how ketosis or the ketogenic diet may or may not be helpful for maybe not treating, maybe treating. I've certainly seen some interesting effects in some of my relatives when I give them exogenous ketones where suddenly their sentences are three or four times longer, 30 minutes later, which is wild to see. But in terms of prevention or staving off the onset of some of these diseases, I'd love to hear your perspective. But let me tell people what I've been doing for the last few months and especially in the last 18 days. So for the last whatever it is, I think I mentioned six months, I've been doing intermittent fasting. And that was after hearing conversation between Dr. Rhonda Patrick, who I'm a big fan of, and Mark.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Thank you for that. And I want to bookmark maybe we come back to this. But if people are trying to think about this, understanding that the science right now is maybe provisional or there's a little bit hypothesis worth disproving at this point, but that it seems to make sense, right? From an evolutionary perspective that both muscle memory and metabolic memory would be a thing. Otherwise, it makes sense your body would want to adapt to be prepared for the next famine or whatever it might be.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Also, find it much easier now that I started doing intermittent. I've been intermittent fasting pretty much every day for the last six months, which means I'm eating between typically 2 p.m. and like 8 or 9 p.m. And having two miles. One question I have for you, which is just for Timmy Tim, Tim, but we'll apply to other people, is there an argument to be made? And maybe I'm totally off base, but if you follow a ketogenic diet and make it work for a multi-week period of time that you're changing your metabolic machinery or just your body in some way that has carryover effects even after you stop the diet? Or is that me just doing some hand-wavy fancy footwork as a muggle? I don't know if there's a there, but what are your thoughts?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Without subduing the highs, right? I've never had mania necessarily. I'm not talking about that, but I'm not muted. I feel just calm, stable, sharp. And that's one reason in and of itself to do it for periods of time. But I seem to feel a carryover effect also have Alzheimer's and other neurodegenerative diseases in my family. I have three relatives with rapidly advancing Alzheimer's at the moment. So maybe we could talk also to how these things might intersect. But my feeling is possibly, and I'd love your input here, if I follow a ketogenic diet for a number of weeks or maybe a month and a half or something like that, I'd love to know the timing you might recommend. Let's say I do that two or three times a year, that there could be enduring effects that have protective carryover. And I...”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“For mood stabilization, and you mentioned metabolic psychiatry, and you made the introduction, I believe, Chris Palmer out of Harvard on the podcast to discuss this, but there are certain conditions, whether it's depression, but even more squirrely when you're dealing with something like schizophrenia, for instance, or different types of bipolar, people who have been on dozens of medications who go into, let's call it remission, or they no longer meet the criteria for the diagnosis of some of these things after being treated on a ketogenic diet of one type or another. It is astonishing. And so for my own mental health, I've noticed complete stabilization.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Going into cancer therapy because those people studying ketosis for chemograin, like reversing chemograin and like managing that. So it has a broad array of applications. It's targeting the tumor growth and putting a break on it. It's not a cure for cancer. And I cringe when people talk about that like online, the ketogenic diet, curing cancer. It does slow it down, especially if it's highly glycolytic, which 80% of cancers are. enhances and augments the response to the standard of care that's radiation, chemo, and immune-based therapies. So we kind of, we know that now. All right. So why have I been in ketosis for 18 days and why am I doing it a few times a year? Well, this is part of how I implement this does hinge and will continue to hinge on some of the answers in this conversation from Tom because this is very self-interested. But what I have found is that”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Is it fair to say, Do you think most of the benefits that someone would derive from fasting prior to cancer treatments, they could also get from ketosis or is it dialed back to smaller percentage of effect? That's a good question. I think it requires a nuanced answer that we probably don't have time for. But if you are overweight and your BMI, for example, is like, you know, as many cancer patients tend to be like 28, 30, 32, a fasting or a calorically restricted ketogenic diet is the way to go if a patient is trending towards being lighter, like a BMI, 20, 22, something like that, a eukaloric, meaning like keeping stable caloric level to maintain your weight is going to be important and then elevating beta hydroxybutyrate will be important to get some of the anti-inflammatory effects and also the immune boosting effects and the neuroprotective effects.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
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2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
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2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
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2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Fasting ketosis as it relates to cancer, we may come back to it also, but we've had prior conversations about this and the benefits, some of the incredible effects of fasting prior to cancer treatments of various types.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Things like that. I had an inbox full of people that do that, and I would like to do experimentally go down that direction to understand why. But I think there's two reasons you're targeting the energy systems and you're augmenting the immune response to keep the spiro key in a dormant stage or maybe eradicating it in some context. It's really incredible on a whole lot of levels. And I'm just lucky that I had the prior experience with the ketogenic diet to even have it occur to me as a last-ditch effort. And for people, if it wasn't clear, I mean, you explained it clearly, but glycolytic simplifying here, but it means that something needs to eat sugar or metabolize carbohydrates to survive, right? And there are also, Dom, correct me if I'm wrong, but particular cancers that are very sensitive to being starved of glucose as well. And for people who want more on sort of fat.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“For I'm giving my brain this alternate fuel that it really likes ketones, but it didn't explain necessarily the durability of the changes. In brief, do you have a theory or an explanation for why that would work?”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Of my cognitive symptoms disappeared. And I stayed in that state through nutritional ketosis for a few weeks, had complete remission of any of the cognitive symptoms plus the joint pain symptoms. And those never came back. And I recommended that, and this is not a randomized controlled trial, but over the years due to various factors, we've had ticks growing in population also expanding to the coasts and on the west coast that is and elsewhere had three friends replicate this with ketosis after suffering various symptoms from tick-borne disease. And, you know, we were texting, maybe even talking about this, but I never had a great explanation for why it worked. I said, I don't know the exact mechanism. Maybe I have faulty glucose metabolism that was somehow, maybe something was impaired by the ticks and therefore.”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Turned into several months even post antibiotic treatment, which I do think is important, of we could call it pseudo-dementia. I really felt like I was operating at 10% cognitive capacity. And basically at my wit's end, I said, well, what can I control? Because a lot has not done the job. And I went into strict ketosis. What does that mean? That means that I'm consuming moderate protein, probably getting at least 50% of my calories from fat and keeping my carbohydrates to less than 20 grams a day, probably at that point. And within three or four days, I'd probably say around day three or four because I wasn't very fat adapted at the time. My body wasn't well trained to use fat because I wasn't doing intermittent fasting, which we'll come back to. And within three or four days effectively, all”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT
“Chronic fatigue or depression searching for a diagnosis that is external. I feel like sometimes the cottage industry of diagnosing and treating people for quote unquote Lyme disease can be shady at best. But in this case, I'm coming from Long Island. Everybody in my family has had tick-borne disease and was credibly diagnosed. So the second time I had Lyme, I got to a point I did not see the bullseye rash, assumed I did not have it, which is a mistake because sometimes you don't see the dermatological response and you nonetheless have contracted something like Lyme disease. I ended up weeks later slurring my speech. Took me minutes to get out of bed because my joints hurt so much, forgetting friends' names. And my assistant said, Timmy, you really need to see someone. This isn't fatigue. I've seen you sick. I've seen you tired. This is something else. And suffice to say that...”
2026-01-07 · The Tim Ferriss Show · #845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) · IDENTIFIED FROM THE TRANSCRIPT