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Jeffrey Goldberg

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2025-08-20
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2025-08-20
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  1. And we have people in our community participating, but we have people who fly in from everywhere to participate in these clinical trials. So we're happy to see if we can fit you into.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  2. Yeah, absolutely, Tim. You know, you joked in the beginning that this podcast is yours and certainly allowed to be self-serving, but I'll throw one plug in here at the end, the Stanford ophthalmology website. We actually maintain a list of clinical trials. And again, if we want to tap this whole team here on the back, our faculty, our clinical research staff, everyone involved in it, STEM to Stern is fantastic. And I'd like to point out a lot of the clinical trials of trying to pull things out of the lab and test them in patients for the first time, a lot of work on vision restoration, vision protection and restoration clinical trials going on right here. My work and some of the work of our amazing faculty and staff here. So you can actually go to the Stanford Google Stanford Ophthalmology Clinical Trials. We have a webpage on our Stanford ophthalmology site that goes disease by disease and has contact info and how you plug right into the trials here.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  3. You know, I think of one in our backyard here in San Francisco called the Glaucoma Research Foundation. There's another one in New York City called the Glaucoma Foundation, dozens more, of course, but like they also maintain websites that have a lot of patient directed information, patient facing what to learn about your disease. You know, you were asking before, like, where's a reliable source to learn about stuff? That's one. But they'll also sometimes talk through like what's happening in clinical trial space or where is that happening or where some hot spots for clinical trials. So I think that's another, those are a couple good resources. Of course, nowadays Google, you know, just any web search engine, you know, it'll get you started in the right direction.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  4. One really good place in the US to look is a website called Clinical Trials.gov. So it's got it right there in the name. And you go on the front page for clinicaltrials.gov and you type in your disease. So you could type in glaucoma, diabetes, whatever it is. And it'll give you a list of here's trials that are recruiting right now actively. And then you can click on any of those and say like, oh, that one's in my city or it's not in my city, but I'm going to call or send the email to them anyway and say like, hey, could I be eligible for that? So that's probably one great resource. And then the other would be, again, for diseases would be in the case of like, you know, research for specific diseases, almost every disease has one or more foundations or patient support sites that bring people together.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  5. Come be in the clinical trials and volunteer their time and energy, the extra trips to the office to get their eyes measured or special pictures taken or all that kind of stuff. So I say like, I know you're grateful to be in this trial, but I'm grateful to you too. We are grateful to the patients. So I think we've all got to participate in science as a community so we can do these trials and figure out like how we're going to fix ourselves and go from disease to normal. And by the way, go from normal to supranormal, right? We got to prove it, right?

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  6. So, first of all, science is real. And second of all, I would just encourage people ask your, in this case, eye care provider, like, you know, what's going on with me? Are there clinical trials? Like volunteering to be in clinical trials. I'll tell you, I know like patients are so grateful when they get into our clinics here and they get into a clinical trial because they are accessing a treatment before it is publicly available to see if it's going to work. We don't know if it's going to work, but they're taking a swing at that and they are so grateful to get into these trials. But I always say like we are so grateful. Like we can't do the trials and therefore decide whether you should take the supplement or use this virtual reality device or go in front of red lights every day or microdose LSD or change your microbiome. We can't figure that out if we don't have the patient.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  7. I want people to understand that, first of all, these are all amazing questions. You've hit a wide range, and we can't answer them without doing the science behind it. So first of all, as they might be Dry and said, science is real.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  8. Oh my God, this is a guess what you're thinking. You better, you know, when we're in training for medicine, we get asked questions like this all the time. And some of them are like, okay, I want you to guess what I'm thinking. Go ahead. Three trials.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  9. Do nothing because you feel like I'm not, I can't do, I can't do a million hours, so I'm throwing in the towel and I can't, I won't do any. You know, half an hour, four or five days a week, brisk walk at that heart rate up, have it count, you know, easy, you know, like make it easy on yourself. If you want to then go nuts and do like hardcore weight training, hit your peloton, have your trainer, you know, train for a marathon. Okay, fine. But that biggest difference in your life was going from none to some.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  10. If you go from some to twice as much, yeah, there's an improvement there too, but not as big as the value proposition of going from none to sum.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  11. I think the important thing for listeners is that, and when I say listeners, I include myself because I intellectually know I need to do more exercise. And, you know, I still got to figure out how to get around to actually doing that more exercise. So I'm in the listener crowd here of what I need to say. The important thing to remember is that the biggest gain comes from going from none to some.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  12. But a very big contributor is going to be your lipids and your blood pressure because those are going to contribute to what we call microvascular disease and ultimately brain atrophy as we get older and ultimately cognitive function. And if you could be really ahead of the curve and be really clean with your lipids, whether that's with diet and exercise or upgrading to some of the medicines that help with that, and really clean with your blood pressure, again, diet and exercise or there are medicines we can give to help with that staying ahead of the curve on those is almost certainly a huge contributor to your later cognitive health.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  13. We don't have like a great blood test for your mitochondria yet. Obviously, you could get it sequenced. We don't know how much your fidelity to mom's mitochondria might play a role in your future cognitive health. I would add to your list, though, two other standard screening tests that certainly are likely to impact your cognitive health as you age. And with that, again, the eyes part of the brain, your visual health too. And that's going to be your lipids, your fasting lipids, and your blood pressure. And, you know, like every bit of science points to, yes, you can inherit it your APOE genes that can change your risk.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  14. You're hitting it. That's exactly what I was talking about. So you got DNA from the mom, you know, in the egg. So you got DNA from the dad in the sperm, but you could take a third party's mitochondria outside of their cell, inject it into that egg just like the sperm went into the egg. And now that egg with mom and dad's DNA and a third person's mitochondria, including their mitochondrial DNA, will propagate and form the whole embryo. And it's an amazing headline. Like, does that mean there's three parents involved?

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  15. Yeah, yeah, yeah. And look, it's cool. Look, I mean, I just read, they're now doing successful mitochondrial transplants. Like, for example, into an embryo. So you can have inherited diseases where the disease is inherited because you're mitochondria are bad. Mitochondria get most of their proteins and lipids and all of that that make up a mitochondria. They get most of that built from the nucleus, the regular DNA of the cell. But they have a little bit of DNA themselves that makes some of the proteins inside the mitochondria. And so you can inherit that mitochondrial DNA that has mutations and have real serious diseases. It's now been shown you can transplant mitochondria so that baby will not have an inherited mitochondrial disease. Is it that far off to think that we could like transplant mitochondria into the retina of your eye and stave off?

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  16. Facing with the mitochondria metabolism biology. And so actually a lot of these supplements that are about metabolism end up having some link back to mitochondria.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  17. But it turns out they're yet a third thing. So they're powerhouses, their social creatures, but they're also scaffolds. And they're actually like kind of the foundation upon which a lot of other cellular signaling that's regulating what a cell is supposed to do is happening on the surface of the mitochondria. So you got metabolism, energy, scaffolding of signaling. And so no wonder half of our neurodegenerative diseases are associated with one or another defect that we can trace back to mitochondria. So that kind of adds up at the end of the day when you look at it that way. And some of the things we've already talked about, I mean, you brought up red light therapy. That would be one for sure. But vitamin B3 nicotinamide, it's directly affecting some of that metabolic signaling that is interfering.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  18. Mitochondria not only are they social with each other and they actually talk to each other, they actually fuse and then separate. They get trafficked up. You know, neurons, you know, we talked about the ones that stretch from the eye to the brain.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  19. Translational research, clinical trial research. And I think we're just kind of seeing those two converge right now in an amazing way.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  20. Just in the last decade of being able to like map the brain, not just even down to the cell level, but the cell cell connections called synapses were now mapping entire brains at that level and understanding how they talk to each other and recording and creating, we've got a colleague here who just had an amazing suite of papers, Andreas Tolius and his colleagues creating a digital twin of the entire brain. And then you can do experiments on the digital twin of the brain. You don't have to actually do them on an animal or a person to start. You could start there. So the advances in neuroscience and understanding of plasticity and all of these elements, I think are converging with the advances that we've just been willing to make over the last couple of decades in healthcare, health-related research, discovery research.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  21. Two to three decades now of increasing support for science, you know, at the federal level, but also startups, biotech has had an amazing age. And that biotech, you know, when you've got an amazing age cooking on the pharma side like Big Pharma, that then trickles down. So that means startups can say like, hey, let's roll the dice and test this anti-aging formula because if it hits, there's a market for it at the end of the day. Like this is important. These are big impact areas. So I think the investment that we make in science, and we're sort of like coming to a head, a culmination. And I think that happens to be matching in time the advances we've been making in neuroscience. I think we made like huge advances in immunology and cancer biology a couple decades ago, like even just understanding what all the cells are. And I think that the analogy is the advances we've made.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  22. Know, I was teasing before, but the truth is we eye people love to work closely with our colleagues in brain because there's so much shared science. I do think that there's an increasing attention to, hey, let's answer these questions properly. Let's do proper trials. Let's really study these things properly and let's also move things out of the laboratory and into human testing, right, and have it not just be like kind of the fantasy and the mice, but never move it to the person, right? And so I think that transition, that willingness to grow in that direction, we've had actually, to be honest, like a remarkable

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  23. I will not be surprised if our colleagues in the brain follow quickly. And maybe we could restore cognition in people with severe cognitive disease, Alzheimer's and these others. So I think this kind of restoring the central nervous system, including the retina and optic nerve, spinal cord injury, I think this is all we're going to topple that in these next few years

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  24. Be surprised if our colleagues in the brain Follow suit quickly. You know, we like to tease who's going to come first, the eye, or the brain.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  25. Has been totally unexpected and totally unprecedented. And the science supporting these directions and these diseases is getting really, really juicy. We have discovered so many molecular pathways. Well, during development, the retina, those cells are all developing. They learn to, you know, wire up together, do it right. How do we get a cell that we're going to put into an adult person to say like, hey, I know all you other retina cells are already neighbors with each other, but I'm moving into the neighborhood and I want you to accept me. But we're figuring out how to like induce that plasticity, like open up the neighborhood, let that cell get into the network start to participate in the network and restore vision. So it is moving really quickly right now and it is starting to translate this laboratory science is starting to really move quickly into appropriate, safe human clinical trials. And so I think that is going to be the biggest topple is going to be that we can restore vision. And I will.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  26. For this. And it comes back to these big ticket eye diseases like glaucoma, maciodegeneration, even diabetic retinopathy, and other less common versions of these degenerations, let's say of the retina, the optic nerve. And we have always said, I mean, I even said earlier in the podcast with you, Tim, that glaucoma is the number one cause of irreversible blindness in the world. And that, I think, is going to be the piece that we overturn. We have always said, like, hey, we got to prevent you from losing vision. We got to slow down the disease because once you've lost whatever vision you've lost, I can't get that back for you. And I think that is about to topple. We are about to get into vision restoration at a level that

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  27. Skip the UV by either having full spectrum lighting indoors or through the window and you've got a nice sunny window. The sun that comes through the window, the glass actually filters UV light. So that's fine. Your car window filters UV light. So even if you're not wearing sunglasses inside the car, you're getting that full spectrum sunlight. Go outside in the morning, fine, you know, get that first sunlight if you want. But there's no data that suggests that part of that full spectrum light has to include UV light.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  28. Incredible. But no, full spectrum light, white light that goes from violet through red, full spectrum light. There's a lot of decent evidence that that's good and important. By the way, let's come back to the development of nearsightedness. You know, we used to say like, oh, maybe people are getting nearsighted as kids because they're spending too much time's indoor reading. And so it's just like too much near work is leading to nearsightedness. There's now pretty good data, actually, that it's not the near work. It's the being inside part of reading inside. And if you just send your kid outside and let them read outside in full spectrum lighting, they could still be doing their near work or doing their homework, whatever it is. But it's the full spectrum lighting that will actually slow down their development of nearsightedness. So you can get full spectrum white light.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  29. You're in steelworks. You've got anything where you've got kind of eye injury risk, wear protective eyewear. It costs like a buck fifty at Home Depot to get those really attractive plastic glasses that are wraparound. But wear them when you're in those work situations. That's a big one too. You know, you see a lot of athletes now wear eyewear, and sometimes it's for sun protection, but you'll see a lot of them when it's not that sunny day or they're even playing inside. And they might be wearing it for prescription, but also just for eye protection.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  30. Year just to make sure, because if you've got diabetes and it's starting to affect the retina inside your eye, we could get ahead of that. We've got good treatments that can prevent you from losing vision. So we want to stay ahead on these diseases. That's the main thing. Other things, you know, everyone's going to get cataracts eventually, but what can we do to slow down the development of cataracts? Well, one real easy one is reducing UV light exposure. So you're out in the sun a lot. Wear sunglasses. All sunglasses made today have UV protection. By the way, all regular glasses that don't have darkened tinted shades, they also block the UV light from going through. So even if you're wearing your regular glasses outside because you need glasses, that works too. So wear sunglasses or some sort of eyewear protection. And then eyewear protection is another big one, like depending what industry you're in. You're gardening.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  31. A bunch of things. First of all, get an exam, and if you have a family member or blood relative with eye disease, you know, maybe get that exam even sooner. Take glaucoma as an example. If you get an exam and you're 40 and you don't have a family history and your exam was normal, you don't have to come do that full exam every year. You could come back in five or ten years, try it again. But especially as we get older now, half the people in the world need glasses. Half the people in the US need glasses. you might be going into your local eye care provider, optometrist, getting your glasses checked each year to anyway, just to see if you're still in the right prescription. And they can do the full exam, check for everything else, make sure nothing else looks suspicious, leave you in great shape. So getting that periodic eye exam, especially as we get older and more of those age-related diseases like macular degeneration, glaucoma, et cetera. Obviously, if you have diabetes, you're supposed to get an eye exam every

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  32. Different cocktails. That's a great way to put it. Yeah. And platelet rich plasma, again, one of the reasons that that looks so rejuvenating for our bodies is, again, it's just like chalk-a-block full of growth factors. And so I don't know, I'm sure somebody's testing this as another way to treat really severe dry eye. Or if your dry eye is so bad, you're actually getting like kind of ulcers on the surface of your eyes. Some of the most severe cases might really benefit from like serum tears, maybe platelet-rich plasma would work too. So that's a hot area right now. And again, filled with growth factors.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  33. Serum and plasma, yeah, depending how you treat some of those proteins, that's serum and plasma. Let's just say you're spinning out the cells. And then you can take that serum. Maybe you dilute it a little bit in some of that preservative free artificial tears. Maybe you just use it straight. Usually we dilute it a little bit. And we can give patients their own serum as artificial teardrops. And that serum is filled with really good, juicy growth factors that help the surface rejuvenate. And that's the principle of in some patients using serum tears.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  34. That tube of blood has your red blood cells carrying all your oxygen, your white blood cells, which is like your immune system, and then all just the liquid with the proteins in it. That's what we call the serum. So you could take that tube, you spin the cells out.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  35. That, for example, reduce inflammation on the ocular surface to help the tear quality and quantity bounce back a little bit. And then we also have drugs that contain growth factors, things like nerve growth factor that are almost certainly also good for the surface. And when our eyes get dry, the surface, the reason it feels irritating is not just because it feels dry. It's actually because the surface starts to break down a little bit. And when you go to sleep every night and your eyelids are closed and nothing can evaporate, you know, it bounces back a little bit by morning, so it kind of regenerates or rejuvenates the ocular surface can regenerate pretty well every day. But at some point, your eyes are getting dry enough that you're having much more chronic problems. And that's where sometimes we can use what are called serum tears. So our blood serum, if you take out a blood, like a tube of blood, you're getting your blood drawn.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  36. Bad fingers or bad, you know. By the way, if you've got bad vision, you're poking yourself in the eye with it. Anyway, that's what we recommend. Switch the preservative free. And then people who need more than that, we actually have.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  37. They're the cheapest. But if you're getting to the point where it's three, four, five, six times a day, maybe you work on the computer a lot, so you blink less and your eyes get drier, you want to use more of those, then we usually recommend at that stage switch over to preservative free artificial tiers because it turns out that preservative in those bottles of drops at a drop or two a day, fine. But if you're getting up to a lot of drops a day, The preserve it is actually irritating and kind of inflammatory to the ocular surface. It actually kind of breaks down some of the cells on the surface of our eyes. So at that point, we like to switch people to recommending the preservative free. They're the ones that come like usually they come in like a little strip of tiny little plastic. You break one off. It's got its own little cap on it. It's got this tiny little bubble of fluid that you can squeeze. It really tests, you know, if you've got.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  38. Sure. So look, actually, the most common eye disease as we get older is actually dry eye. As we get older, we make fewer tears. We also make lower quality tears. Our tears at high quality have a liquid phase, like a water saltwater phase. There's also like an oily component to good high quality tears. And that oily component also kind of dissipates a little bit as we get older, gets less as we get older. So we make fewer tiers and lower quality tiers. And a real simple over-the-counter solution for so many people is just put in some artificial teardrops. The thing is that those little bottles come with preservatives so that, you know, when you use it all month, by the end of the month, it's not growing bacteria. And if you're just using a drop or two a day, fine. That's getting you by, fine. Just buy those.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  39. There's a thin layer of poop. What we call clean and dirty, he used to say, is really just how thick that layer is. Okay, so that joking aside. If you just shack up with someone who's got great longevity and probably a great microbiome, Good chance you're going to absorb their microbiome. Maybe that'll be good for you. They got to put that on the dating websites, you know.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  40. Because no matter how well you wash your hands after going to the bathroom, like there's a couple bacteria that got on your hands or your belt buckle and your, you know, and then you shake hands or pack someone on the back. I don't want to. Increase anyone's anxiety, but the world

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  41. Let me give you one more idea of what might be that ideal world on the way to that. We share microbiomes between us. Actually, we had our like at Stanford Med School years ago when I was there, we had a microbiology professor. And he used to kind of tease the world is covered with a thin layer of poop.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  42. Between the brain, which you think of like, well, isn't that mostly inside my head? But also the peripheral nerves that are going out to the whole rest of our body and the immune system. And those two are talking to each other all the time. And now we've got the microbiome and that gut axis is like a third leg of that stool because that's clearly also interacting with both the nervous system and the immune system in various specific ways. So we're going to see a lot more of that really, I think, come together and understand more mechanisms. Is it going to be one day that we're all just kind of taking that purified poop pill that we just swallowed down and it changes our microbiome for the day and it protects us from Alzheimer's or glaucoma in the future? We're all hoping that's going to happen. We'd love that protection one day. Should you buy the poop pill off the internet just yet? I'm not sure.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  43. Which are going to have a huge effect on human health by reducing metabolic syndrome, overweight, obesity, et cetera, but also are looking very promising for neuroprotective. And I think it actually gets to that point, you know, you're trying to tease yourself like, are you just like kind of getting ahead of it? But actually, you're touching on, I think, where we're actually coming to as an

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  44. The earliest data Looking at, let's say, diabetes as a marker of, you know, a lot of patients with type 2 diabetes, it's associated with what we call metabolic syndrome, which is this cluster of high lipids, high blood pressure, insulin resistance, right? And so there was initial data suggesting that a little bit of diabetes might actually be like a little protective in glaucoma. And then some of the follow-up, like next set of studies suggested like, no, no, maybe it's a little bit bad for your glaucoma. And so the net net is it's probably not metabolic syndrome as a whole is probably not a huge difference, but I'll tell you the place where those two are converging is one of the hottest topics in medical science today, which is these GLP1 receptor agonists.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  45. Drug therapy candidates that are now moving up through the pipeline in towards human testing to test, hey, if we could like suppress the immune system, not totally suppress it, because by the way, we still want to be like, you know, attacking bacteria and viruses, but just suppress the little leg of that immune system that's attacking our body and leading to neurodegenerative disease, that's going to be off the charts.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  46. The retinal ganglion cells and the optic nerve will degenerate just like in human glaucoma. But in a really beautiful set of experiments that came from a woman, a professor at Harvard Dung Fengfeng Chen, she showed that if you raised the eye pressure in a mouse that was raised itself, grew up in a germ-free environment and doesn't have kind of all the normal mouse dirty gut bacteria. And therefore its immune system is at some level fundamentally different. You can raise the eye pressure in that mouse, but the optic nerve won't degenerate. They won't get glaucoma damage. And then if you take the immune cells out of the first mouse and just put them back into the bloodstream of the second mouse, then the optic nerve will regenerate. So the immune system is playing a huge role that was previously totally underappreciated and they're amazing.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  47. Immune system, and in particular the innate immune system works. We're now revisiting in neurodegenerative diseases, including glaucoma immaculate degeneration. And it turns out it is just packed with evidence that the immune system and innate immunity really play a role. Let me give you one example that is shocking. If you raise the eye pressure in a mouse,

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  48. Decades ago, there was a pretty hot focus on to what degree the immune system might be playing a role, particularly in eye diseases, including the common ones, macular degeneration, glaucoma. Then it was hard to pull that together, in part, I think, because, you know, we didn't know as much about the immune system 20, 30 years ago as we do today. And now we know a lot about what we call the innate immune system, which is not the part that learns about the flu virus and makes you immune the next time you get the flu virus, but just how our immune system interacts with our body normally and how it also might interact with, you know, our gut bacteria and then cross-react with our own body, things like that, right? And so it turns out now that we've got this much deeper appreciation from the whole immunology crowd about how the

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  49. On stem cells, like so, if you've lost your retinal ganglion cell connection to the brain through the optic nerve, we're actually getting pretty good at growing retinal ganglion cells out of human stem cells, like in the laboratory cell culture dish. And we're actually starting to make real progress, you know, in animal models to start showing that you can transplant them in. But I still tell patients like, don't go to some clinic that's telling you they'll give you stem cells and pay $18,000 of your hard-earned money. It is not ready for that yet.

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT

  50. Got to be compatible with daily life for most patients, right? So that does work. That does work. The second most common question I got asked is well, can't you just like fix my eye or give me stem cells or that kind of thing? But number one is cannabis

    2025-08-20 · The Tim Ferriss Show · #823: Dr. Jeffrey Goldberg — Creating Supranormal Vision, Cutting-Edge Science for Eye Health, Supplements, Red Light Therapy, and The Future of Eyesight Restoration · IDENTIFIED FROM THE TRANSCRIPT