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Lukas Czinger

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97
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2026-05-23
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2026-05-23
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  1. 50 million Americans on antidepressants, one in seven? One in six? It's just 50 million kids, 60 million kids bigger than the

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  2. Do we know what it's done to people's brains if they've been on it for 10 or 20 years? Because I remember when these were introduced, when I was in my 20s in the 90s, we became like Prozac, Generation Prozac. They were, I don't know, five or ten percent of my ProSac nation was a book. Yeah, and literally, like 10% of Gen Xers, then maybe 20% were starting to take Prozac and people were sharing their ProSac with each other. It was just like this new way to feel a little bit happier, 10% happier. But yeah, speak to that, I guess. Yeah.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  3. Way I actually did it was I would have coffee up until noon and I'd stop or 1 p.m. Once in a while it'd slip up and have a three o'clock. Then I just told my housekeeper, here's the bag of decaf beans, here's the bag of regular beans. Mix them into a giant thing, shake it up. And then I started just making half cap. I may still be doing half cap. I don't even know, but I just lowered the caffeine per cup and I just tapered myself off. Is that the solution you have is just that?

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  4. On the day. No, I've had. I mean, caffeine is a perfect example. I have tapered off of it before. Massive headaches. And the way I did it, because I was drinking it well into the afternoon. I used to drink an espresso after dinner.

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  5. Yeah, I mean. That's the amount of victimhood and lack of agency and self-reliance that I think is the trick. It's the magic trick that these pharmaceutical companies will then give to you. Like, hey, here's the trick. You don't have to be responsible. I don't have to be responsible. There's another thing. And hey, it's just this is a magic bullet. Tapering off of these though. I've had friends with the Adderall, you know, which is basically speed. I've had friends with the Zoloff and the Wellbutrin and all this stuff. Really hard to get off of. Really hard to get off of. I think getting off of cigarettes. I've seen my friends get off of SIGs easier than getting off of Adderall and Prozac. Tell us about how hard it is to get off of these and then why this modality that you guys are working on and the systems that you're building.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  6. You didn't do anything wrong Not your fault. It's not your fault, Lon, right. And that's the same thing, Mark, that they told people with their pain hey, listen, you have pain. We're going to give you these opioids. This is sinister to me

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  7. Lawn, is that what you believed or the doctors told you when you tried Zoloff? Did they tell you you might have a chemical imbalance or was that your belief when you went in?

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  8. So life comes at you And these pharma companies had a thesis. There's a chemical imbalance in your brain. These are SSRIs are inhibiting the reuptake of serotonin. And that means there's more serotonin in your brain, which means you'll be happier. It turns out there is no blood test or scan or research that has proven this chemical imbalance to be true. Yet, we put hundreds of millions of people globally on this, tens of millions of Americans on this without having actual proof of the chemical imbalance. Theory, correct?

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  9. That's my protocol. But I want you to talk from first principles about how we got here. We'll get to tapering, of course. But how did we get here to where they're not aligned? And am I crazy like sounding like Tom Cruise when I give my protocol or am I prescient and I refined this over time by helping my friends?

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  10. Going to Italy Wow, let's start with first principles. Mark, you're an MD, correct? And you've prescribed these drugs, I'm assuming, or worked. Okay, so you heard my little preamble there. I have a lot of friends who come to me and ask me, hey, JCal, you seem like you're pretty well adjusted and happy. How can I get there? And I say, okay, listen, here's my big five. Sleep, diet, exercise, meditation, socialization. I work with my kids on those concepts, my friends on those concepts. If I have an employee or a founder in need and they say, hey, I can't sleep at night, et cetera. I'm like, okay, here's the protocol. We're going to get you on a whoop or an aura. We're going to start looking at your sleep. We're going to get your eight sleep dialed in. We'll work on sleep. Then we're going to work on diet. Then we're going to work on exercise. Here's your meditation with calm or waking up app, whatever it happens to be. And then socialization. Are you going out and breaking bread three nights a week with people who you love, et cetera?

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  11. As opposed to what I told you, which was hey, go to dinner with your friends, work out, take a workout, take three weeks in Italy, you know, like there's other modalities here. Anyway, let's hear from the founders. Are they helping people taper off, introduce our founders here?

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  12. Look it up. This is an incredible story of just how the pharma companies, their sales channels, the incentives can get misaligned. Profits can ensue, and then anybody who subs their toe, seemingly, would get a bigger and bigger dose of oxycotton, get addicted, then get removed from it, and then wind up taking fentanyl or some street drugs and dying. I look at it now. Young kids now are being massively over-prescribed things. A young kid has a problem. They have anxiety created by their smartphone, by school, by whatever it happens to be. And they just wind up pressuring you. And I've had many parents come to me, hey, what do you think, Jake Al, they're pressuring me to put my kid on anti-anxiety meds on this and that? And I'm like, your kid's 10 years old, and they're literally putting pressure. I'm not kidding. Nine, ten, eleven-year-olds. They're pushing them to scramble their brains.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  13. Incredible with Michael Keaton, I believe, with Michael Keaton and my friend Peter Sarsgaard, who I was in center of the world with

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  14. I know it well, and they were, I believe, at launch festival, and everybody thought, hey, this is an incredible idea. And I was really interested in investing in it and spending more time with the founders. Why? I think these things are massively oversubscribed. I have no issue with people with a doctor doing what they think is best. However, I do think the incentive system in America personally, professionally. And then economically is designed to push people towards quick fixes. Are extremely profitable for the pharma industry. If you look at what happened with that Sackler family and what was the

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  15. Which was pretty easy for my team to resolve, by the way. I mean, I don't want to get into it, but like, you know, if you have a couple of banks who work for you issuing you a credit card or popping up an office space for a day in another city, not really a big deal.

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  16. Ticket holders who are seasoned ticket holders or who have access to those tickets, and they also blocked with their partners anybody from buying tickets who had a credit card address that's outside of the particular area.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  17. Well, I think he can make rules unknown, I guess is the question. Once they're on the secondary market, he can't stop it, but this is the primary market. So I think he can make whatever agreement he wants with.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  18. The Knicks are rolling now. Nine games they've won in a row, and I'm going Saturday. You want to hear a crazy story talk about off duty. You know, I've sat courtside now. In this nine game win. Is that court side for the massacre in Atlanta when the Knicks won? And then I sat behind the Knicks bench and then a little bit behind in MSG. And then I went to the Sixers and my friend Ben Stiller and I sat courtside there. They tried to stop me from buying those tickets at the Sixers. Atlanta didn't seem to be care too much. Now there's a report Dan Gilbert, the owner of Cleveland, and I can kind of confirm this as a breaking news story here. I was acquiring a pair of court size for Saturday night. Person was going to sell them to me. He said, I got a problem. I said, what's the problem? He said, if I sell them to a Knicks fan, Dan Gilbert's making everybody sign an agreement on DocuSign.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  19. Yeah, it's also great for sports. I love watching the polymarkets revolve themselves in real time. So I'm watching my next one again last night. I'm going to go Saturday to Cleveland.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  20. Yes. Big cloud providers may offer you cheap compute, but you'll end up paying the difference in engineering costs and hiring extra developers. You don't want to waste time configuring virtual networks, none of us do, or your access policies. You want your team building your product. So it's time to look at render. Render is the all-in-one cloud platform for developers that allows you. SpaceX merge eventually, which does make sense in many ways. Not just make it dollar sign ELON. You're basically betting on Elon, so just make it dollar sign Elon.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  21. Yeah, so thanks to PolyMarket for keeping us all informed. It's just so great to know where the Sharps are putting their money. There's always people who have analyzed these situations really deeply.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  22. Well, and I think speaks to these paper tigers, as I heard, you know, somebody, I don't know if it's Graham Allison or somebody referred to it as paper tigers, like you think Russia or Iran are these incredible military forces, North Korea obviously. And it turns out some of them, maybe they haven't been updating their weapons systems and technology.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  23. Is that we will still have this war going into it? I think fifth year. I can't believe it, like the first episodes of All In, we were debating this Ukraine-Russia war and that Russia would be in Kyiv. In four days

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  24. And you know, I love to try to understand the world. And the first thing I do, we have a great partner in polymarket. Yes, we do. And I just go to polymarket and I look at Russia. Versus Ukraine ceasefire agreement by. And looking at the end of the year, people were thinking, if you go to that December 31st and you click on it, Lon, you can see the order book over time. And obviously, the order book started high. People thought it was an 80 90% chance. As we get closer, people are like, whoa, this is dropping. And so the number of people involved in this million dollars. And now it's only a 43% chance that we have a ceasefire agreement by the end of the year. Majority chance.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  25. 250k. Should I get instead of 100k? Maybe I should get 20% of the cost savings, which would be 20% of 750K saved. Maybe I should get 150k. Maybe I should make 50% more by making something 50% more profit by making something more affordable.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  26. I think before these Neo Primes, we were having the problem of these things were getting built too slow. And the business model, this is really important for founders. Incentives matter, so the business model previously was called Cost Plus. There's a cost for it and you get a little percentage above the cost. So then the incentive to drive down cost and to do it faster and cheaper doesn't exist. If you make something faster and cheaper, you make less money, right? In other words, if I'm getting paid 10% over whatever it costs to make this missile, the missile costs a million. I get 100,000. Well, what if the missile could cost?

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  27. Built to order in the field, not years before, not on decade-long contracts, but literally being made in real time. It's just a different. It's a different front. It's a totally different

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  28. It's amazing how this military, you know, these neo primes and the competition has been infected by entrepreneurship and also by the venture capital industrial complex. Those two things are absolutely fantastic. And it was an area where we believe that startup ecosystem would not play a role. And now startups are playing a role, which is pretty fantastic because if you look at that, it was a non-competitive space that now has massive competition from startups injected into it. And the way startups compete is they make things that are better. Cheaper, faster, right? Yeah, better cheaper, faster has always been the mantra. And that just happens to parallel the game on the field is, which is commoditized small munitions drones.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  29. You know what? Yeah, move silently. Like sometimes you want to just say less and have that big stick. All right, Lucas, continue success.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  30. Right now, current president's a little bit boisterous and loud. So it's speak incessantly and carry a lot of sticks and bring a couple CEOs with you. Teddy

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  31. Continued success, and thanks for keeping the good guys armed and hopefully we can end some of these conflicts. I'm a bit concerned here about how long this Iran thing is going and how Ukraine never finished. I mean, in some ways good for the military-industrial complex, but I think we need these things to wrap up. What's your take on that, Lucas? I'm going to wrap up, what's the word on the street?

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  32. Always wanted to have a merch store here where we sell this week in startups gear. And once they get around to actually bringing my dream into a reality, there's no better partner than I'm going to use than Shopify. That's right. We're going to set up a Shopify store here for this week in startups merch. And when we do set it up, we're not going to have to wait weeks to get things up and running. Nope. I could just start selling our coffee mugs, crew jackets within hours and all the infrastructure, all the ecosystem from integrating third-party apps to Shopify seamless checkout process. They're all in place already. That's why Shopify is the e-commerce platform behind millions of businesses around the world. They are cooking with oil. They are getting it done at Shopify. In fact, they're powering 10% of all e-commerce in the United States from household names like Heinz and Mattel to companies that are just getting started. So it's time for you to turn your what ifs into. Sign up for your $1 per month trial today.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  33. So you're a neo prime, you're a new prime. Or a micro prime. Are you a mini prime and anchrolls, a max? We're actually not.

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  34. What magnitude cheaper are you at building a drone than Lockheed Martin or whoever else, you're, you know, those major, what do they call it, the major primes?

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  35. That changed the world. Shipping container made the world smaller and the world economy bigger by mark Levinson. This book went like I read the first like three chapters and I'm sorry

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  36. Just the shipping container and how the Changed the world, literally having that become a standard just made the entire world became like a unit of measurement. I'm trying to think of like a gallon of milk or whatever. Became

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  37. Yeah, wow, incredible how far this has gone. Konex just basically containers, right? The military came up with that concept long, long ago. C-O-N-E-X, which is just what is the standard issue today. I think they were different sizes when they started, but during the Korean War, they needed a standard box for shipping, military stuff, and all the great shipping containers now. Lon used that same standard. There's a book about this too I started reading.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  38. Lana, let you ask a question next, but my final question on this technology is the speed at which you make, say, the drone. And if we were using the drones that Ukraine, Iran, and other folks are doing these commoditized drones, I don't know if you build those or just the ones that fly 10,000 feet in the air. And there are like the desert storm drones, the ones that were much more sophisticated than the standard ones that are being used in Ukraine today and Russia during that conflict are those getting to the point where they'll be made in the field closer to the field? And what's the speed? How many come off the line, et cetera?

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  39. V E R.io. So this has gotten much faster. The fidelity has obviously always been pretty great. It's perfect, or is that an issue today or has that issue been put to bed long ago?

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    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  41. What's the option and the number of units where people should use 3D printing versus going to a factory that either stamps it or uses other technology? We're not Printing our whoops. So, where is that number today? Because in the past, people use 3D printing to build the prototypes, but not to build the finished products. At some point, we moved over to the finished products being done on 3D printers, yeah.

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  42. You're building Kinkos for 3D printing stuff. We all laugh, but the idea is, hey, there's a global series of locations to print this stuff. So my question to you is there's 3D printing companies that make the hardware. use the best of those like I know we were investors in desktop metal they were doing metal 3D printing there's a bunch of different people using different types. So you're the layer, the application layer, the service layer for those type of 3D printing technologies. Am I correct?

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  43. Welcome to the program. Tell us a little bit about the hypercar. I remember that and then how you went and pivoted hypercar into, you know, I guess being a partner for the military.

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  44. It'll make like five tabs about that file that you recorded, whether it's a meeting or you taking action items or you writing a blog post, whatever it happens to be. They have a code. Give them a code.

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  45. I click on the most recent MP3 file or whatever file size it puts in there. I hit generate and I go with auto generate, but you can do custom and it will make highlights. It'll make a summary. It'll put the transcript, it'll put action items.

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  46. I like the more elegant magnet thing. And then you just press the little button, feel the haptic shakes. Now I'm recording. Now everything I say I can do. Hey, make sure I go through a plan with producer Jacob and Lon about the community manager coming on board and just documenting where all the communities we have for this week in startups this week and AI all in, et cetera, founders, founder university. Make sure we just at least document where all the communities are so she can hit the ground running. Okay, now I got that on my action item. I'm ready to go. When I drop the plaud pin into my little charger here that sits on my desk. Look at this, Lon. This is a little tiny charger here. When I drop that in, it auto syncs.

    2026-05-23 · This Week in Startups · From hypercars to cruise missiles: Lukas Czinger on the future of US defense | E2292 · IDENTIFIED FROM THE TRANSCRIPT · source

  47. Okay, everybody, it's Twist. It's May 22nd, 2026. Lon Harris is here. Your boy, JCAW. We have a lot on the docket today to get to. But before we do anything, Lawn, I'm just going to grab my plod.

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