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Peter Attia, M.D.

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2019-11-27
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2019-11-27
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  1. I don't think so. I think I could certainly offer about 20 more dumb things I do, but we could save that for another day. We could save that for a while.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  2. And I'll shamelessly plug for our Sunday newsletter, which I know you like. You can sign up for what I describe as a non-lame weekly email.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  3. Right, right, right. Wait a second. So if you want to get through the fine print, so studying studies, which Bob Kaplan and I wrote in 2017, I believe, I think that's a great place to start for folks.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  4. And I exist on any sort of whatever my websites, Twitter, Instagram is all Peter Atia MDM. And that's only because Peter Theo was taken. I hate having MD. I can't say it without thinking about Meet the Parents. Dr. Bob. Bob MD

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  5. It's a fun craft. I mean, again, this is sort of like archery, sort of like driving a race car. Anybody can do it. It's hard to do really, really well.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  6. I mean, it's just such a nascent space. The bottom line is I'm a little embarrassed sometimes when I listen to myself interview. When you hear it the second time, you think, how did you miss that thing that they said? They said something so important. They were opening a door here and you didn't even go in that door. And that's another, I think, part of what the people who are good at this can do is they can release their own agenda and sometimes go where the story is more interesting. And I've definitely seen many examples of how I've missed that opportunity.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  7. Total blank space. And then she came back and then I reshaped it and said, okay, well, I also need to know more about this, more about this, more about this. This is good here. Thank you. This one is good, but can you give me a little bit more insight? So that's like one extreme end of the spectrum. And then other podcasts that I have podcasts where I literally go in with nothing except blank paper to take notes on Wellworth speaking, kind of like what you and I are doing right now for you where there's nothing you need to prep for this type of an interview. And then there's very technical ones.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  8. So, in that case, I'm trying to think. I think Jess took the lead on that analysis. No, I think actually Jess took the first cut. So she came back with... Kind of like 10 pages of stuff, and then I was like, okay, let me digest this for a couple

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  9. It varies totally by the podcast and the subject matter, but so for this one, for the 28 page one, this was a podcast which was very difficult because I was interviewing two people. So I've only done that three times, or maybe even twice, and it's much harder to interview two people. And like you, these are people, like the example you gave, I'd never spoken with them before. So I identified them as subject matter experts. The subject was THC, CBD, all things related to cannabis. So I identified them as exactly the two smartest people I wanted to talk to in the room, but had never spoken. It was all through email. No communication otherwise. And I said to my team, look, These are things I want to understand that I don't know. I believe these are things the public wants to know. I need a dossier that is the best available knowledge you have on all of these topics. And then I'm going to basically look where the gaps are and I'm going to sort of run the sled between the gaps and the snow.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  10. I think part of the problem is I'm still trying to figure out where I am on that spectrum. So I think one of the goals I have for next year is to hone this craft even more and actually sort of figure out what my voice is and then sort of start to double down on the learning around that. Now, of course, again, you could argue that being malleable would be the best outcome. Being able to do one extreme or the other. I don't go into interviews with questions, but I go in with a lot of prep. I have a team that helps with that. So I go in with four or five. Sometimes I did a podcast a week ago with 28 pages of notes going in. But none of them were questions. It was just content.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  11. Man, like, I can't believe I didn't know all of these other things that would have allowed me to take this discussion in another direction.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  12. Well, I'll definitely tell you at the outset, the hardest part I had was, and it's embarrassing because you feel like such an idiot when you're doing it and you realize it as it happens is you're talking over the person. And I just think like in your excitement, you sometimes just like, oh, okay. But I have another question now. And it's like, I don't want to forget these other, I don't want to forget all these questions. So that's something where it's a lot easier in person because body language makes that easier to avoid. I do most of my interviews in person so that that's a bit easier. I think in the end I've learned it comes down to prep. You really, the better interviews are ones where I feel like I'm more prepared. And the interviews that I come out of where I think.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  13. Yes, yeah. And so that's a little bit different. But I love listening to Katie Kuric. I love listening to people do long form interviews. And I've actually asked Katie for some advice, which has been great. And any chance I get to ask somebody who does this for a living

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  14. I mean, those things stress me out, but not nearly as much as the bigger picture of missing the exit or like if an interview is a discussion where you're driving down a road, it's like missing a side road. Missing a side road and getting lost. And I don't know. I mean, I, I think I am better than I was at the outset, but I think this is definitely like the steepest learning curve. And there's so, I mean, I have an aspiration for what it can be. And I do love listening to great interviewers. Now, in the podcast space, it's a bit misleading. So if you listen to somebody like Steve Dubner, who I think is fantastic, that type of a podcast is produced for you.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  15. It's super tough. So it is again yet another thing like archery, like race car driving, where there's this opportunity to be somewhat critical in the spirit of trying to get better. But it's also opened me up to a new world. I never really paid attention to before, which is journalism, like, you know, sort of TV journalism or radio journalism, where you got to be able to think on your feet. You've got to be able to multitask. And for me, I don't know if you feel this way, but I think the hardest thing is. To somehow parallel process being engaged in the discussion that you're having, but allowing a part of your brain to be thinking about where you are on a path and where you want to go. And those are next level ninja moves.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  16. What are they thinking? What would I have thought at that moment? Did they think of, oh, they went down a path I wouldn't have thought of? Okay, what can I take away from that? The good side of that is, I think it allows me to try to become better at this craft. The downside, honestly, is I feel much more pressure now. I feel, and not to the point where it's taking away or detracting from the experience, but I've had to now go back and listen to some of my own podcasts because that's one way you learn is you sort of have to go back and listen to it. And that's just, as you probably know, that's a very painful thing to do. Do you ever listen to your own podcast?

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  17. Well, the other one I had on excited was, which I really owe a lot of credit to you, is this whole sort of podcasting thing and learning might even be too strong a word. Practicing this art of interviewing. It is, so this whole thing started as sort of an experiment a year and a half ago. And I just didn't, I couldn't have imagined how enjoyable it is. I mean, I think what you're doing today is way more fun than what I'm doing. I don't actually like being asked questions that much anymore, but I love asking questions. And I find myself listening to podcasts much more than I ever did before and listening to now two things. One is what's the content, you know, but also, and perhaps as importantly, if not more importantly, is how is this interview extracting that? How is this interviewer?

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  18. Well, now it's different because evolution isn't the thing that's like it's not going to be natural selection that kills us now. We'll just kill ourselves directly, but natural selection could have basically weeded us out just based on male stupidity

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  19. It's just sort of funny to think it's possible our species couldn't have got here, it's possible, like there's at least another parallel universe that didn't quite make it because the male reproductive end of the bargain could not be lived up to due to just constant stupidity.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  20. By the way, for context in high school, for $2. I drank an entire bottle one liter or 750 ml of lemon juice. Know that real lemon lemon juice stuff 750 ml for $2. I drank it in high school

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  21. So here's another question How many times in the history of let's just limit it to Homo sapiens do you think that game has been played by females?

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  22. But if anybody else is listening to this and you're trying to just insert a little spice in your life, I can't suggest the what-if game highly enough. It's really where you'll find out where the rubber hits the road

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  23. I just had a long list of these. I just always do it. I love playing the what if game. And I'm actually kind of amazed at the amount of times she would just veto me based on the stupid thing I said.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  24. That's right, right, right, right. So, like, I loved hefty smurf and I was totally obsessed with him. Remember Hefty Smurf was like the really muscular dude?

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  25. I would do that dance, but I always did that while driving. And I was like, what if I was the exact same guy? But I did that What if I wanted to watch the Smurfs for two hours every single day? I loved the Smurfs.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  26. Yes. And she's like. Probably not. And then, of course, whenever she says that, I'm always like, How can you be so superficial? Like, how can that one thing be such a deal breaker? Another one that she remembered was car dancing. I was like, what if I was the exact same guy, but I would dance like crazy while I was driving. And then I would mock, do you remember in 16 candles when Anthony Michael Hall is dancing around Molly Ringwald at the dance?

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  27. We were in Italy this summer and we walked into a department store and they have this big bright red speedo with a gold belt. And I was like, would you like me if I was the exact same guy? But I only wore this as my shorts. So I would still wear shoes and a shirt, but instead of wearing like the shorts that I'm wearing now, like I would only wear this bright red speedo with the big gold belt.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  28. And I was like, I want you to like literally picture this. I'm the same guy. Everything about me is the same, except for this one little thing, which is I just like to use my toenails to cut the vegetables instead of a knife and a, you know, a chopping block. And, you know, she sort of humor me with that. And I just went over and over and over again. And to this day, I still play this game constantly. And I actually asked her before I came over. I was like, do you remember some of the ones that really like annoyed you when I would ask these? And so she reminded me of a few. So one of them.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  29. Yes. And so the very first one I ever did, this is probably we've been dating for like a few months, and she came over to my place and I made one of my favorite meals is like a curry stir fry, which is a very labor-intensive meal. You're carving up a million different vegetables and all this other thing. And so we're sitting there. We're eating this thing. She's like, oh, this is great. And I was like, would you still like me if I was the exact same guy? It always gets prefaced by that. Would you still like me if I was the exact same guy? Instead of using a knife to cut these, I was like this really flexible guy with long toenails and I used my toenails to cut them. So I sat cross-legged on the floor and I sliced and diced all the vegetables using my toenails.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  30. So, I don't know when this started. Definitely before I got married. But I thought it was really funny to play this game of would you still like me if? And then I would make up something really stupid. And even the game itself bugs my wife, but I make her do it. I make her go through the explanation of why it's yes or no. So I still remember the very first one I did.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  31. With its own problems. But it's the ability of the transit time to get there quickly and not get absorbed because it's not being held up in the upper part of the GI tract with fiber and other solid things that you'd have, say if you were eating it in the form of fruit or even just in a piece of cake, for example. So again, I'm not suggesting, oh, it's good to eat cake, but the single worst thing you can do is drink your sugar.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  32. So sugar as a liquid versus sugar as a solid behave differently and also the dose matters. But if you take a bolus of liquid sugar, it's going to make it further down the GI tract than the solid. And certainly in animals, the evidence Lou Cantley actually published this study in science about four months ago, you could basically take a mouse model that is primed to get colon cancer. And if you had three groups. So one group is getting just a bolus of glucose. The other group is just getting a bolus of fructose liquid. And the other is getting a bolus of sugar and fructose together. You could make that animal explode in colon cancer with the sugar, the glucose fructose. And too much of a tangent to get into the why, but it turned out that that effect is probably not present with solid sugar, which does not mean solid sugar doesn't come.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  33. It's the fructose that I'm most worried about. It's the fructose and the ethanol combined I never want. I see because they both go through this similar metabolic pathway. And when they're delivered in liquid form, when the fructose is in a liquid form and the ethanol, which of course is in a liquid form, now you've combined... The velocity problem, the kinetic problem is working against you.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  34. I mean, anecdotally, it's hard to know because your mind is also sort of feeding into a narrative around this stuff. Certainly drinking my Class Azul Reposado seems to be less toxic or than having, well, I'll tell you, I mean, I've given up certain things. I don't drink a Moscow mule anymore. Like I make a mean ass Moscow mule. I love that drink so much. I love the ginger beer, the lime, the whole ritual. But what I really decided was it's just not worth combining sugar and alcohol together. Once in a while, you can have sugar once in a while, you can have alcohol. Putting the two together is like,

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  35. Well, I see a higher resting heart rate, period and a lower heart rate variability for sure and a higher body temperature. And I don't know the last time I had. Who drinks in a night, but definitely it's one to two is also a really big step up. So, you know, look, everyone's got to decide what they're going to do and what their priorities are. And I'm not here to say don't drink at all, but I just have to, I just, I would just say, don't be mindless in your drinking is sort of my point. Like, if you're going to drink, like make it really freaking worthwhile. Like do it for a reason. Don't just do it because the alcohol's there.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  36. It's generally a reduction in REM for sure, a slight reduction in deep and an increase in fragmentation. So you're moved into that stage one, stage two space a bit more.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  37. Yeah, I mean, I'm down to probably three or four drinks a month. That's basically it. And I've gone two months without a single drink. It's like it has to be worth it because even at one drink, I'm going to experience some degradation of sleep.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  38. The other thing is almost elimination of alcohol. I'll probably have a drink tonight, right? We're going out to dinner, like a bunch of friends getting together in Austin tonight. I mean, I'll have a drink tonight, probably.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  39. I have no affiliations with any of these companies, by the way, so I feel totally happy to just plug them shamelessly for no personal gain. And the Uler is a big step in the right. It's really taken the chili pad to another level.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  40. Also, just being very consistent in bedtime and wake up time. And when I'm really in the zone, it's early to bed, early to rise. So understanding your own chronotype, are you an early or late chronotype? Well, you and I have talked about this a lot Incredible darkness in the actual room at night or using, I use this thing called the Alaska Bear eyeshade. It's like you can buy it on Amazon. It's eight bucks. It's like this little silky Alaska bear. It's the stupidest name ever. I don't know why. I love it though. I have 20 Alaska bears because I have them everywhere. So I'm never without one. And I use, I just upgraded in the last six months from the chili pad to the Uler, that's O L-E-R.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  41. Like Ashley Madison. I have no idea. Yeah, yeah, yeah. It might be in the latter, yeah. So I use those things religiously. I'm very attentive to how much light is around me as the sun is going down. I'm also very attentive of not doing stupid things in the evening. We've talked a lot about this, not looking at email, not looking at social media, not looking at things that are going to potentially activate or phosphorylate me in any way.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  42. Yes, Felix and then Gray. Actually, you can see the box sitting over there. So those glasses sitting right over there are my Felix Gray's. And they're just redonkulous.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  43. About. I find, first of all, they actually have published research that documents, actually I shouldn't I don't know if it's been published yet, but anyway, they have data that I've actually seen that demonstrate how much they're able to block blue light. And at least according to my sort of sleep tracking metrics, they're definitely contributing to much more deep sleep than I've seen historically

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  44. I mean, sleep is a hard thing because it's sort of like exercise in the sense that you can't just give somebody a pill that makes sleep better. It really comes down to changing. You have to sort of accept you're going to make behavior change. You have to prioritize this thing. And it's not just the eight hours you want to spend in bed. It's the build up to it. sort of simplest toolkit, which is what I basically employ. I mean, most nights I don't require a supplement to sleep. It's not like I'm taking melatonin or even using Kirk Parsley supplement. I mean, those things are basically reserving for jet lag situations and things like that. But if I'm doing everything correctly, or fasting, you know, that's another time when you need a little bit of a boost. But if I'm doing everything correctly, using the right amount of blue light blocking glasses, and I've recently switched to a new brand that I am freaking super jazzed.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  45. But it's funny, if you think about Silicon Valley right now, right? Everybody's so obsessed with this no tropic and that no tropic. But I don't think people understand is correct nutrition, exercise, and sleep are far better no tropics than modafinil. I mean, modafinil might be one of the most potent no tropics out there, but it's actually not that strong a nootropic. It's actually kind of a weak notropic, actually, by the literature.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  46. What I basically decided a couple of years ago, or maybe a year ago, was in the absence of better information, just having in a portfolio approach to those in the context of the training for the Centenary Olympics was the best of both worlds. So in other words, my training is programmed through the Centenarian Olympics, which requires that you have training a very specific type of training in all three of those legs coupled with the tabletop, which is stability. So you have these four pieces of training, stability, strength, aerobic, and anaerobic. And by doing these every day, or some combination of them every day, you also know that to at least to a first order approximation, you are getting the benefits of brain health. And then, of course, I mean, while we're just on that topic, I think sleep and periods of nutrient cycling and obviously the appropriate steps on nutrition.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  47. So the literature is not crystal clear on that, but if you loosely take three types of exercise, which is modest or low intensity, quote unquote, cardio, high intensity cardio and strength training. If you took those as the three legs of the exercise stool, the good news is they all appear to increase BDNF. They all appear to have benefits, though to different degrees on vascular tone circulation, et cetera.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  48. Anything was on the table, what drug, what supplement, what this, what that. And he came back and said, and we had a framework that was a very mechanistic framework. He came back and said, it's definitely exercise. And I was like, dude, I mean, that sounds like such a politically correct thing to say. Come back with like a real answer, please. That's just sounds dumb. It's exercise. Like, how can it be exercise? Of course, you came back and made the case, and in the end, I believe that case, which is when you look at what exercise does from a vascular standpoint, from a growth factor standpoint, the creation of BDNF brain-derived neurotropic factor, I really believe that And again, you shouldn't take the view that you should only do one thing, but... If you're really committed to brain health, you want to be exercising every day.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  49. I would say the next one here on this list would be, and this is going to sound almost silly, but. I've changed my mind on the benefits of exercise being much greater than I ever envisioned. So I would probably classify as a borderline exercise addict. So for me to say I now actually think exercise is incredible and has all these benefits is sort of a funny statement, which is not to say that I didn't think it had benefits before, but I don't think I understood or appreciated metabolically. So if you just take one example, probably like four years ago, three years ago, I had one of our analysts do this exercise that took him about a year, which was with some direction around where to start, comb through all the literature on Alzheimer's disease and get a sense of what tools in the toolkit would be most beneficial to prevent it or reduce the risk of it and or delay it.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  50. Yeah, you're not the first person to ask me this, and I think it's a great point. I suspect the problem is I love these things I do so much, I barely feel like I have as much time as I want to do them, but it might be the case that as my kids get older and I can do more of these things with them or different things with them, that that would sort of scratch that itch. But there's definitely something to be said for it. I mean, I think ever since I was 13, I've been so, that was sort of a turning point, I think, in my personality or something where I just remember really gravitating towards individual things. A whole bunch of reasons I could probably unpack.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT