YouSaid · the spoken record

Peter Attia, M.D.

lines on the record
189
first
2019-11-27
most recent
2019-11-27
sittings or episodes
1
sources
podcast

Every line below is reproduced as it was said and linked to the record it came from. Nothing here is summarised or generated. Directory · Search · Corrections

  1. It's sort of, it feels, it's just hard to believe that they've figured out a way to make something so efficient. I only shoot with a back tension release.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  2. Currently, I'm using and why. Yeah, so currently I'm using the Hoit RX3 bow, which I absolutely love. You know, it sounds so stupid and my wife laughs at me when I say this, and I'm sort of joking, but not really. Like, I love it so much. It's the only inanimate object I've ever wanted to sleep with in my bed. I just love everything about it. I just love, I love the way it looks and the way it feels. I mean, compound bows, as you know, are just ridiculous pieces of engineering.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  3. So every time you take that shot, it doesn't matter how bad it is. You can't do anything about it. And simply worrying about it increases the probability that that error that's still in your quiver is going to be a bad shot.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  4. I agree. I think it's an emotional audit as well. I think John Dudley, who is probably one of the greatest influences on archery for me. If people are interested in archery and don't know who John Dudley is, you just need to hit pause on this one podcast now. And this is a guy who's a world class archer who also has the skill of being an amazing teacher. So a lot of people can be world class, but they don't know how to explain to schmucks like us, like how they actually are doing what they're doing. But John is that really rare intersection of someone who is exceptional, but really knows how to break archery down. His teaching is, I mean, one of the greatest lessons I learned from him, which is obvious, but it's really good to hear it from someone so good, is You have no influence over the arrows that are not in your quiver.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  5. Control in the area that we hunt, it's so much the case that the government is basically killing these animals and just leaving them for dead or burying them. And you instead get to go and try to use your skill to do this and then harvest the animal and then feed your family and feed yourself. I mean, the whole thing is just, it's such an incredible experience that has changed many things about the way I look at food like it's made it. It certainly reduced my appetite for consuming food that I haven't had some relationship with. And I think my aspiration is by next year, meaning by 2021, to only eat food that I've killed. Which I think I'll be able to get there by next year.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  6. And so when you think about the complete and utter stupidity of that type of behavior, I've now realized archery is always going to be an amazing teacher because either you go up there and you just have this amazing day where you're in this flow state and everything goes well and it feels amazing, or it's some variation of not going that way, but you get to practice this skill of distancing yourself from the narrative that is dude, you suck. You suck. How can you be so bad at this? And all of these awful stupid thoughts that sort of spiral you out of control. So that's the part of it. And then, of course, the other thing is, you know, then once I finally took these skills into the field and began to hunt and began to experience this cycle of what is it like to go into an area where you have an animal that is a pest that needs some population.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  7. Was something wrong with my bow that I didn't realize at the time, but I ended up lodging three straight arrows into the fence. So I'm taking long range shots, but I missed something in my bow, and one, two, three arrows into the fence. And you can't recover an arrow once it's in the fence. So that's like three arrows I just flushed down the toilet. And I was so pissed that when I took each of them out of the fence because you'd have to snap them to pull them out of the fence, I then proceeded to snap each one over my thigh. Now these are 450 to 500 grain carbon fiber arrows. I was welted for a week. Which, you know,

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  8. I mean, every single day my morning routine involves at least one round of 300. So 300 is the scoring system you use on the paper target when you either shoot at the three spot or the five spot. So I'd like to get 90 shots out of the way first part of the day at the target and then do the longer range shooting, the 3D target shooting. And I will say this. A big part of this is this has been an amazing tool tying it back to part of the training, a new set of emotional skills, right? So there was a day when if I didn't shoot well, that was the end of the day. Everything went off the rails. And I've talked about this, I think, once even on a post, an Instagram post, I was, you know, kind of opening up about this, which was even as recently as a year ago, I remember there was a day when.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  9. It is out of control. I mean, it's like, you know, those life, those huge block targets now. Like the five feet by five feet block targets. I mean, I've got like eight of those. Every animal you can imagine throughout the range.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  10. Yeah, so in early 2017, I call up the local bow shop performance archery in San Diego, just get real lucky. And the guy that happens to answer the phone, JR, turns out to be a complete obsessive. I mean, it turns out everyone that works there was totally obsessive, but JR might even take it to another level just in terms of his technique obsession. The rest is history, as they say. And it's now at the point where in some ways my life revolves around this thing. If you come to our house, I mean, you haven't been in a while. You need to see what it looks like now.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  11. Yep, unbelievable gear. And after watching you go through that journey of training for and going on the hunt, I was like, you know, I'm going to get a bow. It just might be one of those things I want to do every couple times a month.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  12. So this is something that you deserve quite a bit of credit for, but just sort of archery. And again, it started out totally benign as, oh, maybe I'll just get a bow, you know, Tim has told me about why he enjoys this, and I've got a bit of a sense of, you know, and just for the listeners, I guess the story is it would have been the summer of 2016. You were getting ready to go out on a hunting trip. The irony of it, of course, was it was with a guy named Jonathan Hart, who I would get to know years later.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  13. I will say this, I'm nowhere near as good at it as I used to be. I remember trying to do a couple of phone books like a few months ago. And it's definitely a technique you have to stay up to speed on. The first one I fumbled on a little bit and the second one I got after it.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  14. It's not like you can't find the number in it, but now it's just a bigger mess. And yeah, she just reminded me of that like, I don't know, five years ago, she's like, do you remember that night? Like you tore all those phone books. So I don't know. I don't know what it was about it.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  15. She's like, definitely not. I was like, I'll show you. Let me show you the technique. So then I pick up the second one. I tear it. She's like, okay, definitely don't do that again. Of course, I tore all five of them. And it's like such a dick move. Like, that's five people that didn't get their phone book. And I always left the haves there. Just in case.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  16. So I was like, here, try to tear it. My 100 pound wife is going to tear a phone book. And she's like, I can't tear it. I was like, watch. I tore it. She's like, why did you tear that phone book? I was like.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  17. Yes, exactly. So now I go through medical school tearing every phone book in sight. I just can't stop. And I'll conclude this stupid story by saying how it has a funny ending, or not ending, but a funny point in the middle. So I don't actually remember this. I only remember this because she reminded me of it. But on the very, very, very first date with my wife, which was in Baltimore, which we met at Hopkins, were downtown Baltimore and not in like the pair part where you get killed, but in like kind of a nicer part of Baltimore. And it was that time of the month or year or whatever when the phone books were being distributed. And so we went to this dinner called the Sobo Cafe. I still remember. And as we walked out, there was a stack of like five phone books on the doorstep of an apartment building. And I said to her, like a little child. I was like, do you want to see me tear a phone book? And she was like, no.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  18. At some point, if your technique is impeccable and you're strong enough and it really just comes down to grip strength, it's not like the strength of your biceps or something like that. It's basically how strong are your hands and how well do you know the technique, you become limited by hand size. So for example, I could never tear the Toronto phone book It was simply too big. I couldn't get my hands around it. Now, at some point, enough strength will overcome it. I'm sure if I were stronger, I could have done it. So the sweet spot for me was about three inches. And so I wanted to move, I wanted to go someplace where the phone book was sort of two and a half to three inches, all things equal.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  19. That is exactly right. It was like Cookie Monster. So I remember in college I rode my bike everywhere. And this was back again in the era of phone booths and phone books. And so anytime I rode past, even if I was late for class, if I saw a phone booth, I stopped, laid my bike down, went into the phone booth, grabbed the phone book, tore it, got back on my bike, rode to class. So I just left in my wake, torn phone books everywhere. So fast forward a couple of years, I'm applying to medical school. I put together a spreadsheet of all the factors that go into the decision of where do you want to go, what kind of research opportunities, what's their ranking in the U.S. News& World Report, what's their success in getting you into the residency of your choice, what type of this, blah, blah, blah, blah, blah. What is the size of the phone book in that city? Was one of the columns in the spreadsheet?

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  20. Nothing. Like just totally, and the woman comes up and goes, what are you doing? And I was like, oh, I work at a camp for kids and we do a lot of paper mach ⁇ and the phone books are the best for paper mache. And she was like almost apologetic. She's like, oh, oh, oh, okay. I think I mumbled like it was a campfor kids that had less than a week to live or something stupid thing. Yeah, it's awful. So we leave the store with as many phone books as two guys can carry, go back to his house and I practiced that night until my hands bled and I could tear phone books. And by the end of that night, I was very good at it. And then it became fully pathologic as an addiction. So I could not see a phone book and not tear it. You're like,

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  21. Land Rover or whatever. No, he had like a, I don't know, some Toyota like forerunner. That was it, yeah. And I still remember in a silver forerunner, we drove to the mall, which was like 20 minutes away, and we went into the phone store because they had phone stores inside of malls. This is like pre-cell phone. And they had a wall of phone books, like hundreds of them. And I just, I don't know why. Like, it was just such an obnoxious thing of me to do. I just started grabbing all the phone books. And the woman comes up and she goes, not a word.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  22. So, when I was in college, a good friend of mine named Todd Remington, I never forget this, I was at, so it was his wife and my then-girlfriend were like best friends. So we were, all four of us were at their place. And he came home with a phone book, like a standard two, two and a half inch phone book. And he goes, do you think you can tear this? In college, I was like really strong, right? I was like, probably not, but let me try. And I like, you know, just wailed on this thing and of course could not tear this phone book. And then he shredded it, like just ripped it in half. And I was like, oh my God, how did you do that? And he's like, you know, he immediately just told me. He's like, look, it's a technique. And he explained the technique. And I was like, all right, well, do you have another phone book? He's like, no, that was our only one. And I was like, all right, we got to go get more. And this was back in the day when you had phone books. So I remember this. We got into his.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  23. Let's fucking force it. What's funny is, looking at the stupid thing, I'll just tell you what it is and you'll see why it's really fun cheating. So the next stupid thing on my list is tearing phone books. But I will say it's not out of rage.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  24. Yeah, I mean, and we could, if we were to really double click on this topic, that's exactly the direction we'd go, which is it starts with a little bit of self-empathy and introspection and realization of, well, let's examine the why. This must have served some purpose at some point. This was an adaptation to something. Let's acknowledge that. And in the words of Terence Real, who I just recently interviewed for my podcast, Know it's taking that adaptive child in you and thanking them, but just moving them to the back seat, like making sure their hands aren't actually on the steer.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  25. Yes, exactly. So I just think that that's my personal example. But for someone who says, you know, I'm just not filling the blank enough or I'm too filling the blank. I do think a lot of us start to buy our narrative and we just start to believe the story. And for me, that is... Is by far the most hardwired story I've ever believed about myself. And there are lots of stories I believe about myself, right? I mean, we all have our insecurities, and I'm to this or I'm to that, or I'm not this enough, or I'm not good enough, or blah, blah, blah. But this one was like, no, no, no. That one, you don't get to change. Like, that's eye color. And there's not even a contact lens you can put on it. Like it just is what it is.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  26. As angry as I was during sort of anger heyday. And so I don't know, to me that's amazing. Because I now have this confidence that I've never had before, which is two years from now, I might only be 50% of what I am today. And that would be 25% of what I was at the outset.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  27. I have two copies of an APO E4 gene, which is a genetic template that would make you much more likely to get Alzheimer's disease, but arguing that it's a given that you're going to get Alzheimer's disease. That's not the case. These are not deterministic genes. And similarly, I don't think that these flaws in our personality are deterministic. And while there may be people who are more or less predisposed to be one way or the other, and then of course events in life can reinforce that and push you more into that. And then the response to that can reinforce that. So all of those three factors can drive you in a given way. I know this sounds like a very glib example, but I really think that with enough work, you can start to overcome these deficits. And I think that for me. I think I'm only 50%.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  28. What? I mean, what are you doing? Like, why are you such an asshole? And so I preemptively struck at him, which was, look, I don't even want to hear about it, man. Just like, I'm not meant to be around other people. You know, I just remember going launching into this tirade about how I am not really designed to be around other people. Like, there's just no two ways about it. Like, I'm way too volatile. I'm way too angry. I'm way too, you know, all of these other things. And I think I've carried that belief system with me Up until about a year ago, up until probably, yeah, up until about a year ago, maybe a year and a half ago. And I now realize that that entire narrative is simply incorrect. It's no more correct than saying

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  29. I mean, I'm even too embarrassed to tell the story, but my wife and I had a fight, which was basically just me being a total piece of shit. In other words, it's not even like there was any symmetry in this. It was just I was 100% wrong and I dug my heels in and I was such a jerk. And you could sort of tell my parents were just so sad for us. And I think sad for me at my sort of miserable existence. And I sort of remember my dad not saying anything, but sort of his body language being like...

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  30. Okay, this one's a little heavier. I think that the fate of one's personality may not actually be set. I think I have historically believed that we are born With hardwired motherboards and our personalities are set in stone and there's no changing them. And in particular, I think for me, you and I have talked about this a lot. I've never known a time of not being angry. I think I was probably just a pissed off fetus is sort of my, I don't think that's actually true, but that's been my belief template. I don't know. I think just a few years ago, I just, maybe more than that, maybe 10 years ago, even 15 years ago. I remember kind of having this discussion with my dad once. It was really sort of a sad day because my wife and I who had been barely married, we might have been married for like a couple of years and my parents were over.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  31. Got two different types during the fast. I use Slow Mag, and I use L3 and 8 in the evening. So SlowMag, I take two SlowMag in the morning, two Slow Mag before bed along with two magnesium L3N8 before bed.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  32. I'm thinking next year of changing it to three days a month just as a way to mix things up. It'll be a little less socially intrusive. The week of fasting becomes a little bit of a grind. I only do it when I'm away from my family and I always go Saturday to Saturday. Or sorry, I always go Sunday to Saturday. So I do Saturday and last meal is always a Saturday and first meal is a Saturday. Whereas I was thinking, yeah, what if I just did like a Monday, Tuesday, Wednesday, the first Monday, Tuesday, Wednesday of every month or something like that? That would be an alternative way to do it.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  33. It's a eu caloric ad libidum keto diet. So the purpose of it on the way in is generating ketones so that when you enter the fast, you suffer a little bit less. The rationale on the way out is to prevent me from eating like an idiot.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  34. So, for the past couple of years, I've done the same thing once a quarter called the, I think Bob calls it the KFK Nothing Burger. So it's a week of keto that leads into a week of water only fasting that is sandwiched on the other end or boo-ended by another week of keto.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  35. You think about how potent fasting is as a tool that we don't know what the dose is. It's like, I've got this thing. It's called Tylenol, and I know it reduces fevers and prevents muscle soreness. How much do I take? I have no idea. Like, think of how frustrating a problem that is.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  36. The most important one would actually be death. Would be lifespan. But, you know, if we could gather other indirect measures, disease specific measures, depending on the budget for such a study, if we could also kind of shotgun and look at some metabolomic proteomic signals as well, that would be especially interesting because the only way we would ever triangulate on this in humans would be to look at biomarkers in humans that are surrogates of good things happening, so things like autophagy, the inhibition of senescent cells, reduction of inflammation in areas that we don't really want it to be. Those would be kind of the two prongs of this thing, which is get the hard outcome of mortality in the animal model, try to get some biomarker data, and again, it just, like I said, it really...

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  37. Yes And then maybe you've got the whopper, which is like once a year they just do a mega fast, which for a mouse would probably be 24 hours. And then the idea would be... Follow them over the course of their lives. And if you pick a mouse that's like 12 months old at the outset, you'd probably know your answer in about a year and a half.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  38. That's right. And you have to be very careful about what that looks like, by the way, in animals in captivity. So you might have to actually put them on a confined number of calories, and maybe it's not ad lib. And then you'd have different fasting regimens. So you'd have the equivalent of three days a month. What does that look like? Maybe that's, I don't know, that probably works out to be something like eight to maybe eight hours of fasting, 16 hours of food exposure. I have no idea. And then there's the, well, what is seven days a quarter look like or nine days per quarter?

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  39. So let's just say, and again, I don't know if you would do this, but let's just say it was agreed upon that mice would be an appropriate model. And let's just say that... You agree that there would be three arms, right? One arm would be mice that were on regular mouse chow. And it would be important that it would be proper chow, not nonsense chow. Like a lot of these studies are done with pure sugar, high fat nonsense chow. The goal isn't to do that. The goal is to take healthy mice and then picking the right strain is in and itself a huge decision that would have to go into this. So you have the ad lib feed. So these are the mice that are allowed to eat normally.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  40. In the next couple of years, come up with the next best answer. And until that time, unfortunately, I'm going to continue to flail, which means I'm going to continue to fast, but do so without much real insight about what the quote unquote best way to do it is, or if regimen A is better than Regimen B. But I think this idea of just saying, you know what, look, NIH is probably not going to fund this because I don't think this is a question they're that interested in. Industry is not going to fund this because you can't sell a fast. You know, VCs aren't going to fund it. Like when you look at all of the traditional funding vehicles that would go into exploration of question, this one really has to come down to philanthropy. And I have no interest in like creating an organization to do this. So why not just bring a coalition of people together, find the right people, and just directly fund them?

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  41. Yeah, yeah. So, should it be mice? Well, you know, mice have the advantage of being really easy to study and you could probably know the answer in a year. And that might be the answer, but it will require people really smart to understand what the equivalents are for mice in fasting. And it's not going to be a linear extrapolation from our humans. Like, for example, a mouse that fasts for two days dies and loses 25% of its body weight. I'm continuing. Sorry, just being an idiot. Yeah, yeah. I mean, I have no idea what it is like ferrets. I mean, I just don't know. But what I really want to do is

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  42. Would take too long Yeah, yeah. If you want a hard outcome, which is actual mortality, you have to do this in an animal model.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  43. Again, it bothers me greatly that I don't know that. So it sort of occurred to me that what we need to do is form a little coalition, and a number of my patients have already said, oh, sign me up, I'm in. And we'll basically put a pot of money together and find the best people who understand and can help us pick the right animal model because we're not going to be able to study this in humans. Like you have to accept that we're in the option B territory. There is no option A. There's no, let's do this experiment in humans and study them for 20 years

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  44. And people ask me, rightfully so, but Peter, how do you know to do that? Someone will say, well, I fast three days a month. And that's a comparable number of days, total days fasted, but what's producing the ideal physiologic response that would lead to life extension at a minimum reduction of disease risk?

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  45. Is the question of studying something, is basically taking, yes, so it's basically saying, okay, I fast seven days a quarter.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  46. So, what I've realized is, and I've vented about this many a time, in fact, I have an entire Sunday email devoted just to my vent on this, which is it really bothers me that we don't, like if fasting is such a potent tool, and I don't think anybody who's studied nutrition or biochemistry would disagree with that, it's sort of odd we don't know how to dose the tool. So as you know, Tim, I fast for about seven days a quarter.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  47. Okay, the next thing I have on my excited list is Just overall the space of fasting and the potency of fasting, but it's sort of taking a page out of your playbook, right? So the work that you've done recently with Johns Hopkins is basically, and I was talking about this with a bunch of people today at the race, and they were like, what is Tim really excited about these days? And I said, well, you know, and I kind of walked them through your thesis.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  48. That's right. So now we have championship belts for my eggs. And it's one of those things people always say, Peter, when are you going to start making swag for your podcast? The first piece of swag I would ever make would be championship eggs, like the championship belts for the eggs.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  49. And I don't know if you know this, but Nick Stenson, who works for me in the podcast, actually built championship belts for the eggs. Oh, I saw them.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  50. Well, no, no. The plan was I was going to go to the ER and pretend I had a groin injury and have them do a CT scan of my pelvis with Ramanujan in my pocket. Because I wanted to see what was really going on inside of him.

    2019-11-27 · The Tim Ferriss Show · #398: Peter Attia, M.D. — Fasting, Metformin, Athletic Performance, and More · IDENTIFIED FROM THE TRANSCRIPT