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Rhonda Patrick

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111
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2014-06-10
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2014-06-10
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  1. “They can find me at FoundmyFitness.com. That is my Twitter name as well, foundmyfitness, and my Facebook name. And it's the name of my platform. Break this all down for people.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  2. “And everything. So it's like, I think a better approach rather than focusing on these little minute possible bad things that are may or may not do something is focusing on what our body needs to function properly, like indefinitely. You need to make sure that you are getting the things that you need for your body to deal with stress. You need to make sure that you're getting the things that you need to make sure your body can deal with DNA damage, that it can deal with all the crap. Of just normal living metabolism, immune function, these things produce inflammatory molecules and also react nitrogen species, react oxygen species. These things are just from normal living.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  3. “The thing is, I think it comes back to this focusing on not focusing on what not to eat, not focusing on, you know, I mean, plants have a whole host of genes in them and proteins in them that are insecticides and pesticides that are being produced to keep bugs away themselves without us putting it. So it's like you can focus on every little bad thing that's in something. I mean, you'll find it in everything.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  4. “Pretty much, yeah. But, you know, it's kind of weird how the Paleo community was against, I don't know who started that meme, but.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  5. “I personally like consuming legumes and I love lentils. I love eating bowls because these fibrous in them gets broken down into short chain fatty acids in the gut. I mean, this is great for your gut. Keeping your gut happy.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  6. “Yeah, you know, it's like it makes sense. Your body is designed, it's very resilient. We can deal with stress. We have a whole host of enzymes in our body and proteins that deal with crab. Those things need cofactors to do that. So it's like you said, I wouldn't say 15 gallons of ice cream, but the point is.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  7. “I think the stem cell reprogramming is. Well, and it's huge. I'm shocked I don't hear more people talking about it in the next 10 years. I mean, we're talking about regeneration.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  8. “And not only that, biology is so complex. There is nothing more complex in biology, no technology will ever, ever, ever compare. So, we don't even understand how everything's working. And so making sure”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  9. “That's why the Vitamix for me makes it so much easier because while I do also eat salads and I also cook my vegetables too and getting that broad spectrum like I think there's micronutrients in there we probably haven't even discovered it.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  10. “Well, low hanging fruit is what we started this conversation with, micronutrients. I really, and not just yet, really focus on these micronutrients. You've got hundreds and hundreds of enzymes in your body that require these minerals and vitamins, cofactors to function. And you know what? You're not going to notice these things not functioning right. It's just not, you're not going to notice it when you look in the mirror. So taking care of those micronutrient inadequacies really is the low-hanging fruit. I mean, it's work, I guess, but it's a lot easier than”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  11. “Yeah, I'm still awake. This is really, you know, I was like pulling your teeth. I mean, it's, yeah. It wasn't pleasant, but I got my teeth crap reserved. They were in New England now and liquid nitrogen.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  12. “Well, it wasn't painful. It was like psychologically screwed me up because I was like Twilight. You know, I was calm, but like...”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  13. “Obviously, if you're a female, And you're going to have a child. Something that's really cool that came out, I don't know, four or five years ago, I think, where they found the placenta. The placenta is like a really rich source of multipotent stem cells. And I haven't actually done any investigating yet on whether or not there's companies banking that, I would be shocked if they weren't. But that's another really good source cord blood, stem cells, teeth, males, teeth. I mean, I think, you know, well, the bone of opportunity.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  14. “I think banking yourselves now, like if you, you know, for example, if your kids are losing their teeth or you've got a couple of wizened teeth or you're...”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  15. “Exactly. And so if I were working on that, I would take advantage of that system and try to see if that, if you now use that system to deliver it to this You know, fiberblast cell, getting it in the right spot”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  16. “I don't know, I could be totally just making, I like to make connections and come up with new possibilities, but I'm thinking that this new way they can do gene therapy with this targeted, I didn't read the paper. It came out recently. This new technique that they can do, I think they use CASPAs or something where they can actually target a gene and put in the exact locus where it's supposed to be.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  17. “We are heading there. I mean, right now, you know, we can do this low efficiency. They're now working on finding. The problem is that some of these transcription factors like CMIC, which is one of the ones that is required, is also cancer promoting. So they found that, you know, like if you're doing this in mice, 20% of the mice will get cancer. So they're trying to figure out the subtleties.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  18. “Exactly, in which case you don't have to worry about banking your stem cells because now you can just take your skin cells. They've even been able to, they've done it from the urine, what are the renal fiberglass cells that you excrete in urine, those cells?”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  19. “And instead, you make this freaking skin cell a multiplotin stem cell where now they were able to make it turn into a neuron. They can make it turn into a kidney cell. They can make it turn into a liver cell.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  20. “Right, it'll incorporate, it'll use its RNA transcriptase to make DNA and it'll incorporate to random places in the chromosome. So you don't know it could be going anywhere. And the potential harm in that is that you can actually get it in a place where it's like an oncogene where it can cause cancer because you're screwing up stuff.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  21. “It with those four, the way we can do it is we can put it in a virus, a viral background, and the virus will then evaporate.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  22. “So he figured out he had looked at these patterns of gene expression and stem cells, and he had figured out by looking at a variety of different ones which ones are really important for the stem cells that could be multipotent, could form multiple tissues. And what he found was that there's four different transcription factors, those genes that activate a variety of different genes when I was talking about Josa Fox as one of them. He found four of them that were required for a stem cell to be multipotent. And what he did was he took like fibroblast cells. First they started out with mice and then they've done it in humans. But the first study was in mice where they took fibroblast cells. And they”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  23. “Japanese. Now he was in Kyoto, Japan when he first made this discovery in 2006. Freaking game changer, in my opinion. It looks super cool”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  24. “Brought a good question up with the pluripotent multipotent because actually what's really cool now is that we can take a cell, a skin cell, that's terminally differentiated, I mean the fibroblast, they're not stem cells. And people I figured out actually, I think his name is Shinya Yamanaka.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  25. “Yeah, so pluripotent, those, okay, mesenchymal is like the part of this origin of the cell where it came from. Pluripotent means like, for example, if you have a bone marrow cell, bone marrow can form like blood cells that can form your red blood cells, white blood cells. They have a distinct limit to the type of cells that can form. A multipotent means you can actually form multiple different types of cells. So you can take a multipotent stem cell and you can form heart cells. You can form liver cells. You can form blood cells. Totipotent means, I mean Wikipedia people. Right, right. Anyways, the cool thing is...”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  26. “So cool stuff, right? The other cool thing is the reprogramming part, what I was talking about, where they can take your skin cells. They can even take...”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  27. “Was the other one National Pulp? National Pulp Dental Laboratory. Yeah, I actually went with them just because I spoke to their cell biologist and went through the whole, I'm sure they were irritated with me”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  28. “The whole thing. Yeah. And then it's $125 a year. And my husband got, he had to have one of his wisdom teeth removed. So he banged his. Primary teeth are a really great source of kids. They have even more dental pulps themselves in their teeth that you just throw away.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  29. “Like all now begging. Most of them were like they had already been doing the cord blood, so it's like they're doing the cord blood and they've been doing it for like 40 years and they're also doing now the teeth. And so what they do is they'll send your oral surgeon a kit, which is essentially like a balanced saline solution. And the oral surgeon will take out your wisdom teeth and put it in this saline solution, send it back to them, and then they will cryo preserve the tooth of liquid nitrogen. Well, they do a little bit of manipulation, but not much. They don't want to take out the stem cells until you actually need them so that it's good. I did all this reading on the procedure and I let me talk to your cell biologist. I want to see what your procedure is. And I figured out, you know, okay, these guys are doing it right because I looked through the way it's supposed to be done. Anyways, you know, it was about $625 for.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  30. “The other cool thing is that in Italy they did the first clinical trial where they took the dental pulp stem cells from the extracted tooth and they regenerated bone in the person. So these studies have been coming out. They're relatively new. So, anyways, I was like, I'm all about it. So then I looked up companies that potentially could bank my teeth. And I found a couple of companies that I thought were pretty trustworthy. Most of us.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  31. “They do, yeah, there is, but they do a lot of things where they'll irradiate the bone marrow and make the immune system so it doesn't respond to the foreign stuff. There's all these crazy things they do for that.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  32. “No, I'm on top of it. Yeah, so there's dental pulp stem cells in your wisdom teeth that can, because they're from a mesenchymal origin, which means they can form bone, they can form cartilage, they can form teeth eventually. So they can also be sort of coerced if you have the right stromo cells and like stuff around to neuro type of populations, neuronal type populations. What I found studies where they've took human wisdom, so they extracted wisdom teeth from humans, took out the dental pulp stem cells, and then they did mice where they had spinal cord damage. And they transplanted the dental pulp stem cells from the humans into the spinal cord of these mice along with a variety of growth factors and things that are the cocktail of things. And it replaced their damaged motor neurons.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  33. “Coming in crooked and they're hurting I had to have them removed. And there's dental. I started doing all this rating. I was like, if I have to get these mother girls removed, there's got to be some positive thing to it. So I started reading and I found out that there's dental pulp stem cells in the teeth.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  34. “Well, so there's a variety of different ways you can bank your stem cells. Cord blood is one which I didn't, that was up to my parents. They didn't do that when that happened, so I'm kind of screwed there.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  35. “I mean, I really think we are figuring out, first of all, we're figuring out how to reprogram our stem cells. Now we can do that.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  36. “No, no. No, yeah. So these Jumanji Demethylases get activated and pull off these methyl groups, but what I think is going on is there's a chronic signal with age. And I think it's inflammation that's activating these dimethylases and changing the genetic patterns. So I think there's a connection.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  37. “Think what's happening is, I think it's a chronic signal. I have this, I mean, this has to be tested. They've shown NFCAPYB activates this group of dimethylases called the Jumanji dimethylases. I know, isn't this great?”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  38. “Arch gene in our stem cells, and then our stem cells start to die off. And what they found was that there's a demethylase, the enzyme that takes that methyl group off, that gets activated by something called NF-Kappa B, which is an inflammatory, it's activated with inflammation. Inflammation activates NFK.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  39. “The reason why it's not expressed because when it gets expressed, it causes senescence. It causes a cell to stop dividing. You don't want your stem cells to stop doing that because you need your stem cells to replenish all the other cellular populations in that tissue. And so, what they found is that this specific gene, we, when we're younger, don't express it in our stem cells. And as we get older, we start to express this gene.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  40. “They're extremely smart. I mean, they figured it out. Well, to a certain point, because then they take over the host and then they can't survive anymore The thing that really gets me is it seems like there may be a genetic program for aging. And of course, people will say, well, no, aging's, it's a stoichastic damage that's happening. And I think that's absolutely right. And the more I think about it, I'm like, I'm thinking about, for example, our stem cells. We have genes that are not expressed in our stem cells for a reason. They're methylated. One certain gene called ARF is methylated. And the reason is called Arf. Yeah, like a dog.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  41. “Great question. So there are outliers. But there are outliers. And so now they're trying to figure out some people look biologically much younger than their chronological age. Their methylation pattern looks. Right. And some people look, much biologically look much older than their chronological age. And so then they started comparing males and females. And they found that males had their methylation patterns aged like 4% faster. Looked 4% older than the female counterpart. And then they started looking at cancer cells and cancer cells. And they'd get cancer tissue from a person and then they'd get a tissue that was non-cancerous from the person. And they found that the cancer cells looked like their methylation patterns were aged like 40% faster. Like those cancer cells had accelerated their aging. It's really kind of”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  42. “As we age. So it seems as though, which makes sense to me because all these little inflammation, oxidative stress, all these factors are changing methylation patterns. And this is happening as we age. And they're finding now that there's absolutely, there seems to be a systematic change in methylation groups. And they've been able to now look at these methylation patterns from blood cells in people and identify their age with 96% accuracy within four years. I mean, that's amazing to me. It's like, wow, so you're telling me you can look at someone's methylation pattern and tell them it's almost like measuring telomer length. Now telomer length is also”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  43. “So here's the thing that's really cool that I recently, there's a paper, a series of papers that have been coming out over the last, I'd say, five years. They've been able to look at aging cells. And they've done it from, and they started out with blood cells from people. And they've been identifying these methylation patterns.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  44. “Yeah, right The epigenetic factors, it's basically you're altering the expression of your genius without actually doing any sort of nucleotide change. There's no nucleotide change in the sequence of the DNA.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  45. “Isn't that scary? I mean Epigenetics is kind of terrifying in the sense where you're like beholden to what your parents did, but they're also you can change your diet much”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  46. “And these Mayoscat obese, and they get type 2 diabetes. But what they found is that they have offspring, female offspring, that are skinny. They feed their offspring in normal diets. They don't give them a bunch of inflammation type of foods. And this female mice are lean, but they get type 1 diabetes. And what they found was that the father, this corn oil diet, this inflammatory diet actually turned off a gene in the sperm DNA that's involved in the pancreatic eyelet cell insulin production. I know.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  47. “Get it. You know, so I'll give you an example. There is another study that was published a couple years ago. Actually, there's been a series of these studies where they take these male mice It's kind of nice to work with males because then it's not like in utero, it's not something that's happening during pregnancy. You take these male mice and they feed them a really high inflammatory diet like corn oil where they're just getting tons of omega-6 and just crap.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  48. “Exactly. Methyl and acceptors. Yeah, exactly. And the cool thing about epigenetics is that. They're working on this right now. So they figured out the human genome. Now they're trying to figure out the human epigenome. So there's tons of genes, there are patterns of methylation, acetylation, all these things. And what they're finding is that this stuff can actually be passed on to your offspring through the sperm DNA, through your eggs. Well, not your eggs, but...”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  49. “It's exactly like you said, you'll have a methyl group sitting on top of your DNA in this really important region where things need to bind to turn it on. And it'll stop it. Or you'll have acetylation in a part of your, mostly its histones, which open up the histone DNA complex and allows stuff to come in. So it kind of does the opposite. Acetylation usually turns on genes. So Epi, exactly, these things sit on top of your DNA and they turn them on or off just based on that says that other things can't come in.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  50. “Turned off the gene. So these mice no longer had blonde fur, and they also weren't predisposed to get cancer earlier and they weren't obese, you know, this high folate diet in the female mouse before, you know, she was impregnated Turned off that aguti gene in her eggs, actually. So it's really kind of cool. There's other things, stress, for example, inflammation affect methyl groups. So the whole epigenetic field, I'm like on this epigenetic kid right now. I just think it's so amazing.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT