YouSaid · the spoken record

Rhonda Patrick

lines on the record
111
first
2014-06-10
most recent
2014-06-10
sittings or episodes
1
sources
podcast

Every line below is reproduced as it was said and linked to the record it came from. Nothing here is summarised or generated. Directory · Search · Corrections

  1. “Yeah, so what does these Researchers at Duke did was they took female mice and they fed them a really high folate diet NB12 three weeks before they got pregnant And what they found was that the offspring of those aguti mice no longer had yellow fur they had brown And when they looked in their DNA, what they found was that the aguti gene had been silenced”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  2. “Predisposes them to type 2 diabetes and obesity and cancer. So these mice are like blonde hair looks nice, but they get it fat and they come down with cancer acids.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  3. “It's fascinating because diet and lifestyle can actually change that. There was a study, a classic study that was done at Duke University a few years ago where they took mice that are lab mice that have yellow fur. And they have yellow fur because a gene they have called the aguti gene makes them blonde have blonde hair, basically.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  4. “Your blueprint spread. Yeah, well, actually, it also does generate methyl groups that are using this other cycle called the SAM cycle, which actually does make a lot of methyl groups for a variety of different other epigenetic marks. So I think ultimately someone with that polymorphism that's not aware of it. Can have not have enough methyl precursors around. That makes sense for other enzymes to go and add them to different gene regions.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  5. “It's both. There's a gene and the gene makes an end. Makes the end. Okay, got it. So your gene is the DNA blueprint, which then makes RNA. The RNA gets translated into protein.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  6. “Yes. There are enzymes that add methyl groups on and there are enzymes that demethylate and there's whole classes of them. And the MTHFR is a specific enzyme that's very involved in the methylation pattern of homocysteine, methylating it back to methionine when a bunch of homocysteine. But it also does generate some of the methyl group. So it's not that it's adding it, you're not adding it to all your other genes, but I think specifically the MTHFR.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  7. “Yeah, it's destroying all the dysfunctional organs, like the dysfunctional mitochondria yar, and it's a very healthy thing to be able to do because you don't want nasty stuff building up in yourself.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  8. “I don't think there's really a convention I hear both. All right. It's kind of like with autophagy and autophagy. I hear that in scientific seminars.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  9. “And so methylation usually refers to turning a gene off, but not always. You can also have methylation of the histones. So acetylation is another epigenetic mark. Acetyl groups, acetyl groups.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  10. “Yeah, it's literally a physical block. And so, what happens is a gene will be turned, it's there, but it will be off. It won't be active.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  11. “CPG islands in your DNA, and usually when those methyl groups attach to your DNA, what happens is transcription factors have to come Fox was one of those come and bind to a promoter region of a gene to activate it, to turn it on. But when methylation groups are there, it's like physically impossible for that transcription factor to come up with something.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  12. “Yeah, let me, I can explain a little bit about epigenetics and the role that methylation plays in that. So, you know, epigenetics is basically referring to changes in gene expression. And when you have a gene, it has to be expressed, it has to be expressed, to be active, to do what it's supposed to do, to make the protein it needs to make to do that function. And what you have here is your DNA is wound up in protein called histones, and this makes up your chromosomes, and they're wound up real tightly. And you'll have Methyl groups, which can attach to certain regions of your DNA.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  13. “They try to get a lot of these micronutrients as well from their greens. In fact, if you look at their inflammation levels, there's been some people, they don't call it a paleodiet in some of these studies, but if you look at what they eat, it's kind of paleo-like. They've got low-c reactive protein, low inflammation. So it's like, I think in that sense, it's kind of like, you know, you're eating protein, you're activating IGF1, but you're exercising, you're cutting out all the other crap, you're getting all your micronutrients to repair the damage. I think there might be a healthy balance there where you're not.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  14. “That would be very interesting. I think that if you're looking at someone who's following from what my understanding of a paleo diet, I think even though they're eating a lot of protein and getting a lot of IGF1, because they're not getting all this other excess damage, and I think they try to get enough micronutrients, from my understanding.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  15. “So I think that's a hormases is kind of a cool way to do that. And then getting all your micronutrients, making sure your DNA repair genes are working, you know, because there's an environmental component as well, environmental meaning the way we age, to a castic damage happening in our body from just damage, metabolism, our immune system, all that stuff is breaking down stuff, it's causing damage to our DNA, it's causing damage to our lipid cell membranes, causing damage to our protein, and these things get dysfunctional over time. So making sure we can keep all those systems working well by getting those micronutrients is another great way.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  16. “Of course, there's the whole alcohol part, but, anyways, so I think hormesis is a way to kind of get those stressed response genes activated.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  17. “So, I think that doing things that like a little hormetic responses were little types of good stress, like heat stress, exercise, green tea, Kirkerman's another one, that's also a hermetic, red wine, the polycanols and red wine do it”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  18. “I think there is a possible way to get the best of both worlds. I think that, you know, I don't know, it depends on what eating a high protein diet means. For me, eating a high protein diet is like eating some sort of meat every day. If you're looking at getting some of those benefits of having genes expressed that are involved in stress resistance, there's ways to do that through hormetic responses, hormesis, which is basically giving yourself a little bit of stress. Things like polyphenols like the EGCGs and green tea, that's what they do. That's how they exert a lot of their positive effects is through a hormetic response where they activate NRF2, which activates a whole host of genes involved in like glutathione peroxidase, all these anioxidant genes. Really? Yeah. So heat stress exercise.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  19. “But if you do have a bunch of cancer pre-cancer cells around, it's not a good idea to have a lot of IGF1 because it's a growth factor. It's a proliferative signal that's letting these cancer cells grow, grow, grow.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  20. “It's just, yeah. And, you know, they've done a variety of mechanistic investigations to figure out why, and a lot of it has to do with the Foxo pathway where it's like these worms are just resistant to stress. Yeah, so anyways, that's the one, that's a bad thing about having too much IGF1. The other bad thing is the context. If you're healthy and you don't have a bunch of precancerous cells, well, IGF1 is great because it's muscle repair, muscle growth, neurogenesis.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  21. “The worm would go from living 15 days to 30. And it was amazing because I would look at just a wild type normal worm versus the one that we would inactivate their IGF1 pathway. And they would be, let's say it's 13 days. That 13-day year old worm that was normal was like barely moving around. And he was like, and this other dude was just moving. I mean, it was like a young worm.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  22. “So it negatively regulates it. When I was doing this research back at the SALC with worms. These worms have genes that we have, it's really amazing, but when we would inactivate IGF1, cut it off.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  23. “Completely agree. So IGF1 is good, right? But there's a flip side, and that flip side is, first of all, if we're talking about IGF-1 activates AKT pathway, and AKT is, well, there's a lot of things. One of it's involved in the glucose metabolism like you're talking about. But another thing that it does is that it inhibits something called FOXO. Which is a very important transcription factor. And Foxo, when Foxo is not inhibited, it gets into the nucleus and it activates a variety of genes that are involved in stress resistance. It activates a variety of antioxidant genes, genes that are involved in DNA repair, genes that are involved in degrading bad proteins.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  24. “And there's a very good reason for that protein induces IgF1 because IgF1 activates the MTOR pathway, which is required for protein synthesis. So it makes sense that when you're eating protein and taking an amino acids. Right. You're basically going to induce that whole pathway that's like, okay, I'm going to incorporate this to make new proteins in my body. So it's well known that protein is actually one of the most potent inducers of IGF, which is probably another reason why eating protein helps pack on muscle. So IgF1 is a very potent growth factor. It can promote the growth and the repair of skeletal muscle. It also is very important for, it can cause neurogenesis in the brain so it can cross blood brain barrier. You can also make it. And it's a growth factor. So it's helping your neurons grow.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  25. “Know if there's a certain type, I know that exercise itself can induce the muscle cells to make it, so independent of the liver. So your muscle cells will make its own IgF1. So it's sort of a different mechanism than it going through the whole growth pathway. But a very potent nutrient inducer of IGF1 is actually protein.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  26. “So, IGF1 does great things. I mean, IGF1 is downstream of growth hormone. So when you're pituitary, it makes growth hormone, it induces your liver to make IGF1, but also other things induce IGF1 exercise for one, so you can really, you know, exercises are potent inducer of IGF1.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  27. “Right? You know, so basically you get the mutation in the gene that can end up having an abnormal cell. Once you have that abnormal cell This is where promote cancer promotion comes into play, where things that can give growth factor signals. And this is where something like IGF1.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  28. “I think in the sense where you're, if you have a small amount of precancer cells in your body, having a good immune system becomes critical and your immune system needs folate. So I think focusing on having good mechanisms in play that can get rid of those pre-cancer cells. So there's a variety of different mechanisms our body has. When those happen, we activate genetic pathways like P53, which induces the cell death of these cancer cells. We've got our immune system. If your immune system is working well, then it's going to kill those cancer cells. But something that you bring up a really important point, which also gets me back to this whole context thing is that what you're talking about is you've already initiated cancer. So you've already gone through that cancer initiation where you've acquired enough damage to make a cell abnormal. Right. Meaning what usually happens when you...”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  29. “Because it's these cancer cells are rapidly proliferating cells in your gut and your skin and also hair, your immune cells, they're also rapidly proliferating cells and they get affected as well. But cancer cells, yeah.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  30. “So it can cause strand breaks near DNA, which lead to cancer However, if you already have cancer because cancer cells are, they've overcome a variety of different signaling pathways, they're growing and reproducing rapidly because of that. They're making daughter cells while their daughter cells need DNA to make these cells. So they like stuff that helps them have DNA. You know, if you're supplementing with folic acid and you have cancer, you're actually giving these cancer cells the precursors they need to make more cells. And if you think about one of the most famous chemotherapy drugs out there, methotrexate. It inhibits folic acid synthesis.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  31. “A vitamin when we make folate in our body, right? And folate's important for thymine synthesis. So thymine is one of our DNA nucleotides. So if you don't get enough folate or folic acid supplementing with folic acid, you can actually cause your DNA to misincorporate uracil, which is part of RNA, into where the thymine is supposed to be. And this causes strand breaks in your DNA. It causes double strand breaks. Actually, our lab did an experiment where we did folate deficiency and compared it to like UV radiation and it was just like getting UV irradiated not having enough folate.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  32. “Yeah, Can and it is always good to be, you know. Aware of what doses you're taking with vitamins and minerals in terms of vitamins, I think that there are widespread micronutrient deficiencies, as I mentioned. 70% of the population has inadequate vitamin D, and we talked about vitamin K, magnesium. There's calcium as well. There's a lot of these micronutrient deficiencies. So supplementation can be good because it can help fill those gaps. However, you know, if you're a person that is unhealthy in terms of you have a disease like cancer, then all bets are off. Because cancer cells, like everything that normal cells like, but it's like fuel for the fire. So for example, this is, you know, folic acid. Folic acid...”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  33. “And so that's the other one, sodium, potassium. But that's actually a really good question. I haven't really thought about that.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  34. “Don't know for certain if you were to do excessive amounts of. Dark greens, but there are the calcium is also in the greens as well, like kale and charge. Right, right. So potassium's in there, you know, so”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  35. “If you're gonna supplement with minerals, I think you really need to be careful. You want to make sure you're getting the right balance of them. You want to make sure you're not getting too much as well if one or the other. So like magnesium. I've seen studies where they show that the maximum dose you absorb from a single dose is somewhere like 123 milligrams. And anything over that's not bad. Sometimes you'll get like a relaxing effect in your gut so it can. Supplementing with minerals.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  36. “A little complicated when it comes to supplementation. Now, if we're just talking about minerals, for example, minerals are really tricky. Because they are required as cofactors for a lot of enzymes and because they're very small, a lot of these minerals are very similar in their structure like magnesium and calcium. They're right next to each other on their periodic table. They both have this two plus charge. And what happens is if you take a bunch of magnesium, we're supplementing with a bunch of magnesium. And you're not getting enough calcium. The enzymes in your body that need calcium start to take the magnesium and the kind of trashes those enzymes that don't work as well because they need calcium, not magnesium, but they think, and this is something that happens.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  37. “Yeah, I at one point tried to do a little bit of reading on that and I just Didn't find the phytic acid convincing enough for me to start. Cooking my kale and then blending it or? So, but I haven't done extensive research on that. So I can say for sure. It's not a great thing to do, or it is a great thing. I really, personally, I just go with my raw. I mean, I haven't convinced myself”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  38. “Conception slash exaggeration. Well, I may or may not know because I don't know really exactly what paleo is. Honestly, I think meat and berries and vegetables and not processed foods. That's kind of my understanding. I haven't really read a lot about it. It makes sense to me, but...”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  39. “Yeah, so and then I blend it up, and that is my breakfast brings me into lunch. Lunch, I usually have leftovers. From dinner. I try to eat pretty healthy.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  40. “Powerful motive. Exactly. I use it every day, and what I do is right in the morning, I make a smoothie that consists of a lot of kale, spinach, spinach or chard, depending on what I have, two large carrots, a tomato, avocado, Then I put an apple banana. The avocado and banana are really nice because it gives the consistency of a smoothie And like frozen berries, or sometimes I'll switch out with different citrus fruits, almond milk. Almonds are really high in magnesium. Almond milk, I like unsweetened because I don't want a bunch of extra. So I get unsweetened almond milk, and sometimes I'll put my protein powder or glutamine, you know. My gut likes clotam”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  41. “I do. I highly recommend I have a Vitamix, but I mean, whatever your favorite blender of choices, I mean, whatever. I don't blend tech, you know, whatever it is you like. A blender that basically has a good, you know.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  42. “If your liver Right, kimchi, I think maybe has some levels of it as well, but most people don't eat kimchi. Is it nacho or nato?”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  43. “Exactly. Exactly. And with the vitamin K, you'll have calcification in arteries, which can lead to cardiovascular diseases, can lead to brain vascular diseases So, what we think is going on is there is these micronutrient inadequacies are causing what we call insidious damage, where it's a little bit of damage every day. War of attrition. Right. It's just going on, going on, going on. And by the time you're 50, 60 years old, you start to come down with these age-related diseases that are age-related diseases for a reason. So we think that getting people up to snuff on their micronutrient intake is a very important role in preventative medicine because we're going to, instead of trying to patch someone up after they're falling apart, we're going to extend the healthier part of their life. So extend their health span.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  44. “And so, what we think is going on. So, let me just mention about 60% of the U.S. population doesn't have inadequate levels of vitamin K. 45% of the US population has inadequate levels of magnesium.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  45. “Versus this other protein that's involved that needs vitamin K to work is essential to make sure you don't have calcification of the arteries. Well, that's something that doesn't rear its head to later in life. So we look at the binding constants of those two proteins, sure enough, the one that's involved in clotting has a much tighter binding. So more of it's going to that protein.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  46. “We start Exactly. And we started to test this. We were looking at if you look cofactors, the way they work, you have enzymes in your body, and these enzymes are what are doing everything. You have a DNA repair enzyme that needs magnesium. There's a binding constant. That protein will bind to this cofactor, to this mineral at a certain rate. And so you can look at proteins that are involved, for example, vitamin K that's involved in the clotting of your blood versus other proteins that require vitamin K, which are involved in making sure you don't get calcification in your bloodstream. Clotting is a very essential short term survival protein, as I just mentioned. You don't want to hemorrhage out.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  47. “And what this theory is that during our evolution, we went through periods of starvation where we couldn't get enough food and there are these periodic points where we go through starvation, we think that our body has very strategically set up mechanisms that it can ration micronutrients to the proteins and enzymes in our body that are essential for survival, for reproduction, the sodium-potassium pump, your clotting. You don't want to hemorrhage out. So all these proteins that require micronutrients for short-term survival get their pick first. Whereas ones like enzymes involved in DNA repair, which repair DNA damage, well DNA damage accumulates over time and that doesn't have a problem until the fifth or sixth decade in your life. So”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  48. “Source and plants, and that is hard for us to digest, so our absorption isn't that, you know, we still get it, but it's not as bioavailable. There's a lot of things, I think mostly the number one thing is we aren't eating enough dark green leafy greens. And for that for magnesium, Magnesium is essential for about 300 different enzymes in your body. And we in our lab, we have a theory which we are now starting to prove, which is called the triage theory.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  49. “Your gums are falling out You will, for example, not be making collagen properly Because that's what vitamin C is a cofactor for. So, in the case of micronutrients like magnesium, vitamin K, so magnesium is at the center of a chlorophyll molecule, so it's found in dark green leafy vegetables. Men need around 400 milligrams a day, women about 320 or so, and people aren't meeting those requirements because they're not actually eating enough of the foods that have magnesium. And there's a bunch of reasons for that. There's also a lot of confounding factors athletes often sweat out more, so they actually require more than non-athletes, and then you have things like magnesium being tied up in phytates, which is like the phosphorus.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT

  50. “Not necessarily. Inadequacy means you're not so deficient that you're going to have a clinical symptom that's measurable.”

    2014-06-10 · The Tim Ferriss Show · Ep. 12: Dr. Rhonda Patrick on Life Extension, Performance, and More · IDENTIFIED FROM THE TRANSCRIPT