YouSaid · the spoken record

Art De Vany

lines on the record: 130
first: 2017-05-12
most recent: 2017-05-12
sittings or episodes: 1
sources: podcast

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“The possibility, the technology is coming, and it is there right now and inside each person, and it's the protein quality control, cell quality control, don't lose cells. Maintain them Starving them within a while, that's good for them. So the technology, I am applying the technology and I think I'm doing pretty well at it so far. I do plan to live another 40, 60 years.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Just check my Facebook page. That's my, I've given up my blog. It wasn't worth the time and effort. I did help a lot of people. I pass that now. I've taken up this as it really is a scientific quest because one, like I said, I'm experienced coming up on aging, on 80 is you start thinking about, you know, when you approach middle age, you start thinking about these things”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Get ready for my book when it comes out on aging. To feel this full of a lot of charlatans. There's some good science. And there is no such thing as successful aging because aging is damaged. So, you can't be successful if you're being damaged.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Market theory, it's a sensible way of looking at efficient markets. The best predictor of tomorrow's price of something is today's price Because that leaves no arbitrage opportunity. Right. If you knew the price is going up tomorrow, we'd go up today. That kind of thinking. You think about opportunities, but you think in terms of the arbitrage limits that are there. So I talked to general equilibrium theory as arbitrage also. Wasn't too successful. It wasn't appreciated, but this is how Malenvo taught generally equilibrium theory also. The process of arbitrage.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, we'll buy low and sell high, but you trade. You have to trade different alternatives. For example, Nature pours a vacuum and economics abhors an arbitrage opportunity. Arbitrage opportunities get eliminated.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Well, I used to end my principles of economics teaching the importance of freedom and arbitrage. Arbitrage keeps you from being stupid because you compare the price of this relative to other. Equivalents or close substitutes and so forth. If you talk mathematically about pricing, you lose the anchoring from the arbitrage principle. So I always taught arbitrage.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Think students learn more from Fool by randomness. The Black Swan is marvelous as well. Skin in the game is probably going to be a terrific book too because you got to have skin in the game. Everybody knows that, but they always ignore it. If you want to do a Chinese fun, you got to put skin in with him.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Hollywood economics. It covers extreme events fairly thoroughly. In fact, a lot of students looked at that. I had other readings as well. Or you could look at climate science and look at the extreme climate variation. And what happens, you could look at the economics of storms and floods, floodplain analysis. So I would look at nature.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“The last class I developed there at UCI and I taught, and they loved the class, economics of extreme Not uncertainty the way it's taught by utility theory and all this nice utility maximization and expected this and expected that. It's all nonsense. It would be the economics of extreme events.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Entirely into control, but down to a full stretch I've been thinking Tight in spring There's a spring down there. And so even if I'm doing positive exercises, I will lower and I do a little, not a bounce because full stop bounces are destructive, but the little stretch bounce.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“That's right. That's exactly right. So I'm there for a little adventure, for a little bit of intensity, not to get hurt. So if you have long muscles, you do full range of motion, you're not going to get hurt.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“It's usually Sort of mild, and I may start with my so called famous hierarchical sense a lightweight 15 reps, heavier weight, 8 reps, a heavier weight, yet four reps. You're going right up the fiber hierarchy, slow intermediate, fast switch. Now you're warm. You warm up more rapidly if you do something that's reasonably intense and then the rest of the workout, you're warm. I work out. Early in the morning when it's cold, or I used to, and now that I don't have a job anymore, I'm retired. I work out at 11. And every time I go there, I see the same guy. He's an ex-body builder, you can tell. He looks good. He's there for hours and I'm in and out. I don't know who looks better. I think I do, but I'm leaner. He's a more bodybuilding looking guy. They don't look good. When they're not flexed, they don't look good. Let's face it.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“With a barbell. So he's using some weight now. That's nothing. I wasn't warmed up or anything. I hopped on. I said, well, that's easy. And I did it and I pulled the muscle in my neck and it hurt for three months.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, you can jog if you want to, if you want to kill some of your stem cells with. No, you got to have right. You got to do all of these things. So I think the idea of switches in Windows is going to come, systemic signaling is the hottest new thing in aging research, which makes a lot of sense. That is signaling at a distance. I think the stem cell pathways are going to turn out to be just crucial and very, very important. Again, MTOR is sort of misplaced because we got so many sick people in the world. It's bad to be average now in today's world. It's really bad. I've never had average looking chests in my blood work or anything else. Average is”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“You want to stall it if you don't want to over proliferate, but you actually want to be capable of proliferating when it's essential because when you want to renew a cell or rebuild tissues, you have to be able to do that. Bodybuilding and the whole notion of regularity and chronic are totally wrong. You've got to have switches, windows, and you go back and forth, you alternate. Alternating states is the way to think about things. The problem is some of the people have looked at, for example, Cynthia Kenyon's work on the worms and so forth, the foxopathway. There are lots of residual pathways from that are 4-kid box genes that were part of the development process that are now resident in the cells and can respond and defend and repair a cell. For example, if you work out, you trigger Fox P and Fox M proteins in your brain”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“On a continuous basis, and so their misfolding proteins and their damaging the cells and building fat in tissues where it doesn't belong and so forth. So I think all these attempts to stall into are really kind of weird.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“I do think these attempts to manipulate MTO Are kind of pointless. If you chronically shut down the MDR, you're going to shrink to nothing. You're not going to make new proteins. It's Windows. You got to have these switches. The most fruitful papers that I read talk about a pathway that crosses another one and they have switches. You turn them on and off. You age in this window. You don't age in that window. It's one way to look at it.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“I'm still a professor Meredith, so I have access to the whole publications. Yeah. Not bad. Don't get into reading about Dias, it's an endless literature and it's pretty lousy.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, they figured out how to get citations. Economists never, we don't call through them much and maybe one or two co-authors at the most.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“I choose a topic and I look very broadly at the topic from a mathematical point of view, from a biological point of view, which is all my reading now. I must have my bibliography is getting close to 8,000 entries in this Asian literature. And what a goofy literature some of it is. You know, I mean, there's some fantastic articles there and there's just a lot of fluff and redoing and reviews. And sometimes the article, the abstract of the article won't be as long as the listing of authors. It's really a weird field.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, I think he probably still does. I'm sure he's quite healthy still. So that's the primary gift. And I gifted many dissertations to graduate students. I ran more graduate students at the universities where I work than anyone else in the department. The students were drawn. Joined to me, but my ideas were kind of complicated, and so there was not necessarily a good dissertation there in the usual.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“I've been generous with my thoughts more than I have with my books in the sense I've gifted the bulk of my knowledge that I developed on my web page and in my first essay on evolutionary fitness. Knowledge I put out there About the paleo lifestyle, I think, was a real gift I gave to a lot of people who've carried on and developed further. And I wasn't the originator, but Lauren and I were both sort of thinking about Lauren Cording and I were thinking about these things simultaneously. I kept telling him, don't jog, Lauren.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Well, I mean I gave all my library books to the local college library and they were full of Not philosophy. I've thrown my philosophy books away. Why is”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Variety, pruning, competition, pruning things. Like I said, God said, I got these different species. I'll send out. Let's see which one is best, which one gets through the ice age. That's how you do it. And your body is constantly pruning your thoughts. Motivations. And sleep is the way you clean all that up.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Why not just admit that nature knows a lot more than we do and try to live a simple, clean, decent life and eat good food and go hungry now and then, mimic those patterns? There's an air correction mechanism inside each one of us. If you err in terms of being For example, you make some bad cells, some bad proteins, or some of your stem cells go bad, nature's down there cleaning it up because the other stem cells will kill it. It'll consume it or it'll shove it out of the niche just like eagles get shoved out of nestlings, get shoved out of the niche. There's competition going on inside your body constantly. And if you use competition to weed out the weak and the faulty and let the strong survive. So your ideas are competing also. Everything is a question of...”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, I think even if you look at a static diagram of something like the M4 pathway, like gosh, it's so complicated. And then you realize they all have to be in the right sequence too, these molecules. You have to move at the right speed and have the right doses and so forth. You'll never be able to figure that out. So, what you have to do is you have to be an experimentalist, maybe on yourself like you and I do. Vaping on your child or on your dog. I actually had to experiment on my child. I didn't like to, but I had to because the doctors were killing him. So I don't want to get into that too much, but you have to be willing to test hypotheses”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“So I wouldn't necessarily posit that feedback. To begin with because I don't think it's a homeostatic balance there. I don't think that the body attempts to maintain pulses or a balance of melatonin. I think you actually make it during the day too. It's not the sleep hormone. It's a defensive hormone. I mean, it's in plants. Plants don't have to get their rest or sleep. They're not moving around all that much. It's an ancient hormone. It's evolutionarily conserved across almost all species. And I used to know a lot about it. I haven't thought about it in a while. Short of knowledge.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Yeah. So it's Actually, everything I think of, I think, in terms of those protective pathways, immunity, restoration pathways, the whole knowledge that I thought I had before is sort of out the window. You think in terms of these molecular pathways.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Lot of people do, and maybe I did it one time when I didn't know enough about it, but actually it's not. Not going to shut down the pineal gland from making melatonin because you're not really stimulating it to make it in the first place. You're thinking in terms of a homeostatic balance of melatonin. None. I'm thinking about it as a surge that's bringing on protective pathways. I think it's a completely different way. And I don't even take it to sleep. I take it to... All the other, yeah, keep my brain.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“So forth. I don't do anything regularly. But melatonin is much more than just a sleep aid. It's founding plants. It's a resistance, stress-resistant protein. Does have powerful antioxidant properties, but you need oxygens to oxidative molecules or signaling molecules as well, but you need a proper balance of signaling versus chronically signaling oxidative molecules. But there's some other direct, I think it stimulates autophagy in the brain or some of these more fundamental processes that Maybe it brings down Hom”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“I had a professor who was long in sugar when the Castro Revolution hit He finally said, I can't take it anymore. I've got to clear my position.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Isn't that something? Yeah, there's an extreme event right there. It's a little small event, but it really changed the course.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“In addition to that, actually, you're the one to talk about that because you're the guy who's found all the black swans with the startups, yeah.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“It's the big outliers that dominate the industry in revenues. So using that skew, you can design a swap-like instrument that uses the upper tail to pay the lower tail. And if you divide it correctly, you have very favorable kind of gamble.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Yes, yes, I had, because the last talk I gave at Harvard was compared the movies to pharmaceuticals. And it turned out that the same kind of statistical distributions. Lepto Curtani. It sounds like something you should gargle for, but it's actually a thing of beauty. It's skewed in biased to the right and with a very long heavy tail. Heavy tail being. Because every tale is long in a sense, but they become very thin and has a lot of probability out there. That's true of a power law distribution, pareto distribution, and so forth. So it turns out pharmaceuticals that way because a few pharmaceuticals sell billions and billions and billions of dollars, or like $12 billion a year. Most pharmaceuticals sell about half a million maybe at most.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“No, but it's a thing of beauty Because it's where life lives. That's where life is in that kind of fractal type distributions. It's like a Pareto distribution and then they drop down. At the minimum.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“It's a measure of the odd shape of the distribution. It's highly peaked and skewed off to the right or something. It looks very non-normal.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“I guess we all need a black swan hunting device in some sense. I tried to create a financial device. I had a crook for a partner who was too dumb to be able to take this anywhere. I've figured out ways of using kurtosis to finance pharmaceuticals.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“He creates marvelous characters that embody the kind of thinking wants to ridicule or point out as savvy. He likes street smarts like I do. We both like mass smarts too. I mean, actually, he went to the Kuranda Institute. You know, he's a very well-trained mathematician, far better than I.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“No, no, it's not, but even if you live in a desert-like climate, it's cool in the morning. Quite cool in the morning. I keep the pool cold. I don't hate the pool much. And I take cool showers. I don't try to shock myself.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Well, I walk the dogs early in the morning with almost no jacket or anything. Just go out and get nice and chilly with them. Cold showers, a cool”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“You know, when my first wife was in, was declining. A host of other things. I take a walk in as much as I could Would tell her bad jokes. Change the surroundings. You know, the typical things that people have to do being outside is enormously effective. Their stimuli you can't even relate to, but you perceive them. And your unconscious brain is what's going to heal you first. And the unconscious brain is more healthy when it's exposed to nature and happy people and children and dogs.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Heal the brain. First heal, first heal the brain, and you heal it with neurotropic factors be outside, New thoughts, new patterns of behavior.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Well, starbit exercise, but do something that's totally different so that you set up neural circuits that compete with the ones that are ruminating and building and strengthen your brain. The starvation part of it is to eat up some of these dysfunctional synapses. My saying is for every damaged molecule, there's a damaged thought. And you're a depressed brain or a brain that is. As post-traumatic stress, those are injured neurons inside the brain and you just need to get rid of the dysfunctional molecules that are causing those neurons to malfunction.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“It is hilarious. It has proportional. Shrinking, in other words, you're going to say 10, each synapse is going to shrink by 10%. The biggest synapses are the most active ones. That's where post-traumatic stress lives. So, if you can shrink those, they have to be stable, but if you keep rehearsing that same synapse constantly, it's going to grow in strength. And people who reverberate thoughts in their mind or ruminate a lot, they get depressed because those circuits, according to Jail Adelman, that's neural dormanism. Neural darwinism. Darwin, there's Darwinian competition going on inside your cells everywhere.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“You're going to spend the first window of sleep sort of rebuilding tissues, second window of sleep, you're into the starved foxo mode, and you're also altering your synapses. Here's an interesting new gene. It's called Homer. It floods into your brain when you're excitatory signaling is depressed. Not much glutamate in the neuron. So Homer comes in and it shrinks your synapses.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“There are other factors. Like you expose yourself to some cold. You stress your muscle, you get plenty of good sleep. Very important. You've got to have these. Foxo MTOR windows during your sleep. You've got to live in one window or the other. There's a growth. Repair window, insulin window, and there's the Foxo window. Insulin Tor versus Foxo. That's how I see my life. And I'm going from one window to the other because I can't. F-O-XO. That's a four kid. Proteins, they're four human versions of it. When sharving, Fox makes you want to move.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“But I couldn't when I was teaching at the university. I had a class with 400 people, and half of them had just gotten back from China and were coughing and sneezing and so forth. I was sort of the universal substitute teacher because everyone else got sick and they knew art wouldn't be sick. They'd call me up to go teach their classes. It's spooky in a way.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“To me, I don't, it's a deal with the devil. I haven't even had a coal in 40 years. I'm not going to mess with my immune system.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“They run across the protein synthesis, across the ribosome. All these pathways intersect, and every one of them encodes some kind of stress response, cell protective pathway that's responding to a toxin, rapamycin, to a bacteria. And the thing you don't want to have happen is when a bacteria is in there, you don't want to be transcribing proteins or the bacteria will get into that. You'll be making proteins for the bacteria. So you've got to be able to shut down transcription at the right time. But if you can't shut down transcription or MTOR completely because then you can't make the defensive factors that are required. And this is where these microRNAs seem to come in.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT