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Art De Vany

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130
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2017-05-12
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2017-05-12
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1
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  1. “This was written forms. It's a carbohydrate containing, I hate to tell the paleo guys this. Between the muscles and the washed up seals and an occasional beached whale and the seabirds and occasional inland hunting. That was basically how we survived muscles are your friend, both kinds of muscles. So there's the survival aspect, the DHA, of course, in the seafood. You can see the remarkable photos that show the difference between 100,000 years difference in the human skull. It's a profound difference. You can see that the human skull, the modern human skull that emerged is kind of a juvenileized version of the earlier skull. And the high prefrontal area, the cortex and what have you. So brain expansion clearly occurred in response to two things, the availability of nutrition to help propel brain growth.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  2. “So after Toba, a volcanic eruption, the largest volcanic eruption in the last two million years, humans were basically settled along the southern... Eastern shore of Africa. Huddled there to survive, and Curtis Marian thinks that the seashore saved humanity. The accessibility of seafood along the shore. Vegetables were wiped out for about a thousand years. There was a thousand-year volcanic winter. And vegetables were difficult to come by and the inland sources of animals were sparse as well. It turns out we may have survived on corms. They're a starchy plant that is in the biome of south southern Africa. MS”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  3. “It seems to be all the rage, isn't it? Like they're innocent little batteries that just sacrifice and produce energy for you. Remember they have their own DNA. So, mitochondrial density has to be very low in the stem cell niches. Moreover, the mitochondrial Activity level. For example, humans, people don't know this. Humans have the lowest mitochondrial density of any mammal. Yes. And they also have low reactive type of mitochondria. The L3, we all came off out of the L3 mitochondrial haplotype that left Africa. Remember, mitochondria Eve occurred about 160, 138,000 years ago. By that time, humans were huddled on the seashore of South Africa trying to survive. The temperature was so cold and so much ice was locked up moisture that the Sahara expanded in scope and became very arid.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  4. “I eat only twice a day, so I want long intervals between meals. I want low insulin signaling so that I bring on the defensive and repair pathways. I want to be conscious of maintaining my stem cells. Now, how do you maintain your stem cells? Well, first of all, you don't have too much mitochondrial density down in your stem cells.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  5. “They live on basically glycolysis. And that was how all life lived at one time. And your fast switch muscle fibers also used the most primitive kind of energy sources for movement So the defensive pathways are really the key to it all. And the poets know this. The legend of Tithonus is a legend of the Greek god. Aurora's boyfriend, and Zeus didn't like it. So Aurora pleaded with him with Zeus not to kill him. So Zeus, in his clever way, said, well, okay, you're going to live forever. But he didn't He forgot to say, I'm not going to let you age. So Tithonas wastes away for eternity. And it's a cruel punishment, but it's a correct description of what the aging process is. It's a loss of self-function, loss of cell integrity, a loss of the ability of stem cells to renew tissues. So aging basically is simply damage.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  6. “Sell maintenance, defensive pathways. For example, autophagy is used in both processes, autophagy being the consumption of self-tissues, of own tissues, phage being eating and auto being you, you, you, you, you, you, your own tissues. So a topage you use both an element of the immune system, it's also an element of keeping the stem cells alive and healthy because they're living on autophagy and when they need to proliferate and come out and heal wounded tissues, they go through a burst of autophagy and then they transition into oxidative phosphol, they use oxidative pathways after that. They're in there being defended by autophagy so that the mitochondria don't damage the stem cells. They have to live in a low oxygen niche. In fact, they're very similar to a very primitive form of cell.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  7. “System. Well, you know, aging is really a puzzle. I only started studying it a few years ago and I figured, well, I'm an expert because I'm experienced. I was about 78 years old when I started looking at aging. And I thought it really is a lot simpler than people are making it out to be. It is not programmed. No aging genes have been discovered. The only genes that have been discovered to have any bearing on aging are defensive pathways. Foxocertuans, proteostasis, a host of other defensive immunity, stem cell proliferation. There are four or five pathways that are involved in aging. And in the main, they are regenerative or defensive pathways, like immunity. The immune pathways cross over with your”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  8. “It also does that. See, neurotropic factors are typically growth type factors that rescue a stressed cell. And that does happen. But the other part of it is that you need to alter insulin signaling so that you're actually Bring on the defensive pathways in that neuron, as opposed to the growth factors and the growth signaling. So that would bring on the foxo and sirtuans and other factors in the neuron. So, that kind of signaling, and if you offend. Brain then can send neural signals to affect proteostasis in remote tissues. Now we're into this notion of remote signaling or signaling at a distance, which is systemic signaling. Economists love that kind of Kind of model then adaptive kind of decentralized behavior.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  9. “Yeah, yeah, settling into a couch. You lose your muscle. Your brain begins to degenerate because it's not getting the signals that the muscles release all kinds of so-called myokines. Now that have been discovered. And also a remote signal from the muscle can cause your brain to improve its cell quality, to maintain neurons. One thing you can do is to contract muscles and you'll find you improve what's called proteostasis in the neurons. Not having misfolded proteins, mishapen proteins, the wrong kind of proteins in your.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  10. “Each own brain. Because it's found its place, it no longer needs to navigate the world, and the brain is dispensable. And every bit of protein and substrate that an animal can get a hold of, of course, it's going to eat. So at that point, the C-squared consumes its brain. A lot of people do that too, don't they?”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  11. “And sea squirt's a little polyp that lives in the sea, and it floats around, finds a location, latches onto that Barcalanger, and eats a sprain.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  12. “The adaptive behavior that modern humans have, that rain was the survival instrument. That means that we're here, we have a great brain simply because it's a way of adapting to the challenges that the bureau presents to us. And you couldn't have the brain that we have unless you had a body as well. The brain muscle signaling dominates most of my thinking. So an approach to fitness, think of the sea squirt.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  13. “Get through that sort of thing. You can imagine God's designers, human designers, saying, well, we've got a new kind of model now. It's different from the archaic model in the sense it has a very large brain. It's smart as hell, but it's kind of fat and slow. And God just says, well, let's see if it gets through the ice ages. I have 20,000 years of ice ages planned ahead of it. And that's what happened. The archaic form didn't last. And all the other closely related forms of human beings disappeared at this time. Neanderthal. The Homoha Eidelbergis and a whole host of other, even Homo rectus was still around early on in this period, 200,000 years ago. So they all disappeared and they all disappeared because he didn't have...”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  14. “Led me to appreciate the hunter gatherer kind of lifestyle. That is, if you view uncertainty in the world the way I do, and you realize that we came through a narrow bottleneck only 2,500 or so humans made it through the Toba, the postoba, volcanic eruption, volcanic winter, that was the lowest temperature in the last twenty thousand years was post Toba. And so we came through a bottleneck like that. You realize that we have to be extremely hardy, very robust. You had to be poised. The brain is there in order to adapt to the climate variations that the humans went through. There were 20,000 years of extreme climate variation and a good brain is a good way to.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  15. “Really began the other way around. I always wanted to be fit and strong. And have a beautiful body and a healthy looking skin and so forth. And just like people liken me and look at me. So ego helps a lot in this game But I also was interested in fitness and eating well most of my life. However, that blended with that plus my interest in athletics and I wanted to be a pro baseball player. Eyesight let me down. So that mixture”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  16. “Minimum revenue because it gets it out on a fair number of screens and some people will come, but then where the mouse starts to take over and it can tank in no time.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  17. “The public has to, they're smart. They've learned that if you just look at the sales itself, that's what a lot of other people are doing, but it could be that they're manipulating the sales as a way of signaling to you. It's a great book. So you look at reviews and you see what the author's done before. It might work if you're Tom Hanks in a movie, but then again, it could be huge variants in his groceries also. He's not a sure thing. What a star will do is it will Raise the least revenue a film might earn”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  18. “People use it as a shop. It's the same kind of thing. And actually, a lot of authors will go out and buy lots of copies of their book.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  19. “That would tend to propel a dynamic where you would have an expansive gross. Problem is you also have word of mouth and reviews. So it's a mixture of public and private information, private information being what your friends tell you about it. Public information being reading the box office scores. You put those two together and you just have an enormously complicated dynamics. You can't tell how it's going to do. As a matter of fact, if you don't get the grosses and you got... You may have to allow them to double bill in the second week. That is add another feature to it.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  20. “The past doesn't predict the future, is really the way to look at it. And there's no algorithm to determine how a movie is going to grow. Genre is somewhat helpful, but only because people look at genre. Genre is not a category. It's something that people put, it's a box people put movies in. You really want to know how much a movie's going to make. You have to look at how many theaters they open it on. It's the cereal box effect. If you go into a grocery store and Wheaties gets all the shelf space except for a few inches, it's going to have the highest growth. It might disappear very quickly though because a big opening is a dangerous strategy. It tends to give you dominant revenues in the early weeks, and if people follow the revenues as a means of making a decision how to go, which movie to go to.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  21. “Yeah Torture the characters, right? So the idea is that a great script, a great story, memorable characters. The rest is up to the audience. It may or may not work. An actor has the same kind of variance in his career grosses as does the industry in general. So an actor will make one movie and that movie will earn 40% of the actor's career revenues. Same thing with directors. If you did all the regressions in the world as a statistical technique for trying to predict what a movie is going to make, you would find out that a handful of actors have any significance, and they're sort of flukes anyway, like Val Kimmer came up in the regression equations. He's gone now. I mean, it's not that...”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  22. “Well, you've got to have a story and characters the audience will love. As remember Kali Curry, she invited me to come speak to this screenwriter's guild. And she said, you make a movie by... You make the audience love the characters and then you torture them”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  23. “Yeah, yeah, Mandleborough. He coined the word fractal because it's a situation where the variation is so extreme that the distribution itself doesn't have the normal kinds of limits. It's a so-called wild distribution, as Nasim Taleb calls them. These wild distributions don't have finite moments necessarily. The mean invariance may not exist, such as in the flood example, and that's true also in the movies. It turned out that the movies has such a wild distribution that even the mean doesn't exist. So if you talk about the average gross, you're talking about no movie that ever made that.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  24. “So, if you use something like a Hervindahl index or a measure of concentration, it's constantly varying. In fact, it has no mean. It's the second moment, excuse me, but it's the variance of the distribution of market shares, the Herfindahl index is, and it's infinite, doesn't exist. Malin Voe wrote about this, so did Who's the other guy who did fractals Anyway, it doesn't matter who the”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  25. “Well, you know, it's an industry that nobody understands. Nobody's really written anything very sensible about the industry. The Supreme Court, for example, divorced the studios from the theaters, and Justice Douglas was a guy who wrote the decision, the famous Paramount Antitrust decrees. It treated the industry as a monopoly because they looked at market shares, which if you measure at a particular point in time, Paramount will have so many dollars of the total revenue of the industry, universal will have so many, and on down the line. Problem is that changes every week.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  26. “notion of normal doesn't apply to a person's life. You don't get anywhere by incrementing in small increments. It's the extreme event. And you seize it and you're poised. If you remain poised, you can respond to that kind of significant event. For example, there's this notion of algorithmic compressibility, which is a computer science term that applies to the ability to reduce your life to an algorithm. Can't do it. Can't do it. The novelty in your life is constantly progressing and you should welcome the variance, seize the opportunities. That's the way I think of life, and it's the Zen of evolutionary fitness. That's how life works out.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  27. “The variance, of course, is a measure of the variation in the series. The series, if it has a mean, you know, most people think in terms of normal distributions. Has central tendencies and that the mean and variation are well described by those two parameters. Not true. The damage that's done by the worst rainstorm in a decade does 40% of all the damage that rainstorms do in that decade. It's an extreme event dominated series, just like the movies and just like your life. People fail to realize you don't get anywhere from the drip, drip, drip of the incremental. You get there from some big event that changes your life, like your book probably changes your life. I don't know what changed my life. Lots of things have. But those are the moments that are the power moments in your life. And in fact, the whole...”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  28. “They actually messed up the floodplains and they thought there was a 100-year floodplain, but floods don't have Mean statistics. They don't converge. They diverge. So the variance keeps growing with every new flood”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  29. “Yeah, well, I loved economics. Its study of decentralized mechanisms and organizations in spontaneous order, I got into it because I took an undergraduate class in comparative economic systems at UCLA. And I had a professor who was just profoundly inspiring in that class, George Murphy, and give him credit. He may disclaim my credit, but he was so eloquent in talking about Hayek and Enreco Baroni and a whole bunch of other people who wrestled with central planning. So Taiwan was sweeping Europe and was being promoted even in the United States. the progressive movement at that time. They felt this centralized control, scientific management, top-down hierarchical control would be the sensible way to do it. In fact, I wrote a book about the inland waterways that... Criticize that approach and talked about”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT

  30. “I started with my blog. He got in touch with me and I decided to give a seminar in Las Vegas covering sort of the elements of my approach. And he and his brother Kamal attended, along which John Durant.”

    2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT