YouSaid · the spoken record

Art De Vany

lines on the record: 130
first: 2017-05-12
most recent: 2017-05-12
sittings or episodes: 1
sources: podcast

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“Precisely. Right. Your immunity is brought up also during this. Everybody, everybody who does anything in aging these days has finally agreed basically as a stress response, that that's what keeps you younger. That maintains the cells, protects them. And hormesis is like they want to leave it on all the time. But they would exhaust you. You can't be poised for every possible kind of damage. Remember, the world's full of Maybe trillions of different kinds of damage that can happen to you. And you can't have a precisely tuned damage response to each threat. They have to be generalized. And they're generalized through certain transcription factors and through the way the ribosome makes proteins. So these generalized stress responses, they run across the immune system, they run across the stem cell system.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Yes, it does. You make foxo, you alter the transcription of your DNA, you make new messenger RNA, and the ribosome, if it senses stress in the cell, it'll begin transcribing these protective factors instead of like making all new proteins. Andrew Dillon is a wonderful paper on this. You should try to read. His group has taken the”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“The retape is the messenger RNA. The right tape is the protein that is made by the ribosome. The ribos Only being very complicated, he's very adaptive in what it transcribes. So Foxa will change the transcription factors, so therefore change the messenger RNA. And the ribosome will run across there. And between those two, they're like any universal computer is inheriting what they can do. So you change the transcription factor. You wrinkle up the DNA a little bit and expose other areas for transcription. And the ribosome is what is the coding factor that handles the integrated stress response. Protein transcription changes toward instead of making new proteins, you're making these stress responsive factors. And that's integral to the survival process.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“I would actually like to educate myself. Well, when you're going to make a new protein, the messenger RNA comes out. It's a string. The ribosome is this little bead-like structure that runs across the string, and it's charged with amino acids. It reads the signals on the messenger RNA, and it transcribes these long strings of proteins. Then they go off, and then they're folded and what have you. It's actually like a universal Turing machine, remember? Alan Turing said you can make any computer if you just have a read-write head and a tape. That's what the ribosome is. It's the read-write head that runs along the tape and makes proteins. My neighbor at UCI was the world's leading expert on ribosomes. God, it's so complicated. He gives you a headache every time I've talked to him. So I finally came up with this idea. Well, it's a universal Turing machine. It's going across the...”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“What you want to do is you want to have, you don't want to be transcribing new proteins in your brain when it's not time to do so. You want to be improving the quality of the neurons. So if you exercise, you reduce transcription in other cells because this particular protein binds to m-tor and keeps it from initiating transcription. The things that MTOR does. MTOR is overrated anyway. It's a ribosome that really matters.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“No, there is merely engineering the genes in a mouse to overexpress KT in the fast switch fibers. Profoundly effective, profoundly effective. You can't read that our study and a series of studies by this group, Azumura. And you can't read that without saying, I want all the fast switch fibers I can have. They're not only disposing glucose, they're taking the glucose disposal burden off the liver. And off the brain. So these insulin like peptides that are signaling in the brain too often. You're turning that down because you're taking the glucose disposal burden off the other cells. And therefore you're reducing insulin signaling in those cells. And it turns out that when you contract muscle, you make this 4BE or something like that, which interrupts transcription”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“I make it locally, but you know what a muscle contraction will turn on AKT and so you're not coming through the insulin pathway, but the second half of it, you're rescuing AKT as a survival hormone, a survival protein. They're thinking about the insulin pathway exclusively, but you've got other factors down there. There's some wonderful work done by Japanese isomura and Akasaki and others who show that if you can overexpress AKT in the muscle, That's protein kinase B also, or whatever it is, it'll heal your liver. So exercise your muscles and heal your liver. And how do you do that? You express AKT in the fast twitch muscle fibers.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“When you activate, when you exercise your muscles, you actually create local IGF1 that doesn't necessarily go out into the bloodstream. I have very low serum IGF1, but I have lots of muscle in it because I make it locally. I had an Olympic doctor who looked at me and said, you can't have that kind of muscle and have such low IGF1. And I said, well, I make it locally. Well, he's used to seeing professional wrestlers and so forth. They were just stoking up on insulin and other such things, right?”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Gene transcription changes when you're under stress, first of all because you don't want to make proteins in a stressful situation. Second of all, you have to encode other genes to mount the stress response. And MTOR is doing that because it's getting the amino acids that are coming from the proteostasis process. So, if they want to chronically turn down the MTOR, they're going to waste away. You need IGF one to rescue neurons that are struggling and stressed. You make IGF-1 locally. They're confusing systemic IGF that is in the serum, in the blood, right? From the local. There's local signaling and there's Global cycling in some sense. And in the circulation, you're getting your global signals, but in the muscle or in the brain”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Uh-huh. So, you don't want your proteostasis to collapse. It's not going to collapse if you have these intervals between meals. If you don't turn on MTOR, your immunity is not going to function properly because you proliferate your phymocytes and your T cells. Your whole immune system, rapomycin is an immune suppressor. Because you're shutting down MTOR. All toxins shut down MTOR. Because you can't transcribe in the presence of a toxin, are you going to proliferate that toxin is going to invade all the new tissues you're making? So proliferation in emtor isn't the whole thing, by the way. You stimulate emtor through mechanical stress. When you're consuming damaged proteins inside your cell, MTOR is being signaled. Why is that the case? Well, because those amino acids are now available. And you have to have that because if you...”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“They're talking in the modern world about people who are never shut in or off. Basically, you don't have these intervals between meals and you're overdriving MTOR, so you're creating lots of misfolded proteins, proteostasis is collapsing. The first thing a C. elegans does when it starts to die is its proteostasis collapses.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“look when overproliferation or hyperproliferation is considered to be one of the evils of modern world but it was a necessary adaptation in the past you couldn't have survived if you didn't proliferate rapidly in the presence of food because you wouldn't have another chance later on you had to be very effective at doing that There would have been in the evolutionary times, there would have been a protein quality control process following that because you've had a fairly long interval without food. So overdriving MTOR was never a problem.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“I find the yoke a bit odd and taste and I don't like too much yoke but I don't throw I get tired of anxious very tired very quickly”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Small amount of olive oil in at a moderate temperature, and I don't know, actually, haven't seen my wife cooking the eggs lately. I don't know how she does. Oil free would be perfectly fine with me if you had a pan that, you know, one of these ceramic pans that where things slide off, she never burns an egg either. They're always wonderfully done. I used to throw a yoke away when I'd eat four boiled eggs, you know.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“The taste of cookie has got so much fat in it already. Why would you ever need to have any additional source of fat? And even olive oil I'm sparing with.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Well, first of all, it's an evolutionary non sequitur. It doesn't follow. You would not be seeing large amounts of coconut. Consumption in the Paleolithic, so it It's just odd, merciful, and it's kind of a fad, second of all. And there, who knows in the manufacturers of these things, there are all signs of impurities that are involved It doesn't taste good either”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“They think there are particular kinds of foods they have to eat, but really variety and Flavor Texture, color. That's how you choose your meals.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“And I don't frankly, I don't keep track of these guys. They're just too many people trying to say too many things. They eat too much fat. Absolutely true. A lot of them went off wildly into fat consumption. So they probably have fatty livers by now. Really, I mean, you cannot eat large amounts of fat and not have the fatty liver. You can't, who needs all the energy? They're worried about energy balance. I don't worry about energy balance, do you?”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“It encounters a whole lot of fat in the muscle, so it differentiates into an adipocyte instead of a muscle cell. These stem cells are very plastic. They can take on a fate. Depending on the tissue they arrive to you and with signals they receive they're local. It's local as well as the global signals that are causing that. See, bodybuilders always knew it was volume that built mass. I think this is really generally true. Lots and lots of volume, even two workouts a day. I was around a lot of these guys. I get the volume in a different way. I work out every day, but maybe 20 minutes at the most, right? I do take one day. I don't work out at all.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“If it's both personal, I trust my taste And if something is just like, oh, this is too much of this, back off it. The other part of it is if you want to have a fatty liver, you eat a lot of fat. There's no way around it. You know, you oxidize energy sources according to how easy they are to actually oxidize. So first carbohydrate goes, then maybe protein or fat, but fat salads to go. So it has to go somewhere. And excess adipose tissue is one of the worst things you can do. My body composition is so crucial. And if your liver starts filling up with fat, this is fat where it shouldn't be. This is ectopic fat. Then it's also building up in your bone marrow, in your muscle, in your thymus, in your brain. So fatty degeneration is a source of stem cell disdifferentiation. Stem cell will come wandering out and say,”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“My wife hands me stuff me. Usually I used to do all my own cooking after my first wife passed away, but now she's such a great cook. I have a big mound of spinach with lots of garlic in it. And she makes a lot of pot roast her own way though. It's one in Italian way. Of course, a fair amount of steak. I'll have an occasional prime rib. But I always cut the excess fat off. I don't like fatty meats.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Clear synonyms. If you have enzymes to stay there too long or neural factors of some kind, like stress hormones, you have to eat those up. The whole thing is dynamic protein generation and clearance. So, what I'm doing is I'm working out, I'm stimulating the autophigi process and the proteostasis protein quality maintenance process. So by four hours later, that peaked, it's over, and I'm good and hungry. I have a nice big meal.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“I never have three meals a day. I sometimes have. One Sometimes none, most times two. You don't have to cut calories, it's just the timing. It's the intervals between meals where you have low insulin signaling. Hiatophagy and proteostasis mechanisms like the proteasome is eating up enzymes and you're clearing the damage. Autophagy peaks at about four hours after four to six hours after exercise. All these guys who guzzle right after their workout are killing their adaptive process. You can't have without its proper autophagy, your muscles degenerate. You have to clear the old damaged proteins. And that's how you do it. The proteasome is that little core shaped barrel shaped object in the cell that consumes mostly enzymes that have done their job”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Unfortunately, I did not. Two big tricky legs at Walmart even. And one turkey leg and maybe half a third of a melon. And then I will work out at 11. I'll have a 15-20 minute workout because I like to go around and see if there are any girls there to look at too while I'm there. And I won't eat until four hours after. I'll eat like at five o'clock.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Well, my favorite default breakfast is a giant smoked turkey lake. With a bit of melon. They're very inexpensive and they're fun to eat.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Okay, well, I want a renewal signal every day. The renewal signal is one, it's the fasting before exercise. Then the fasted”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“What have you, so you can at least concentrate on accelerating smoothly and rapidly up and then descending slowly. I mean, Doug McGuff flex this sort of stuff, and probably the best thing about his exercise is the slow descent. But I would never work out hard enough where I have to rest the whole week. I'd do something every day.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“And the way to do that is negatives. Very safe, very effective. Of course, you can't do negatives on everything because it's awkward and right.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Stress any kind of lowering, of course. You had to lift and lower things. I suppose Carrie, even carrying a certain degree of eccentric exercise. But I only, see, this is Stone Age plus high tech. And the high tech part of it is I looked at McAlusa's work on stem cell. Activation, and there's other work on it as well. I wanted efficient, time efficient exercise to keep me injury free. An entry free is really very important. I've had almost no injuries in the gym over 60 years using gyms. I can think of one injury. So you're efficient. Injury free, the fast twitch type of fibers are the ones you're hitting when you do descending, when you get older, your motor neurons aren't as effective. So you want to have the kind of heavy stimulation of the vast fibers. They're the ones that have the biggest motor neurons.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Okay, well, there's a signaling domain down in the Titan protein passes. It sets the architecture, the whole muscle really, and the actin. There's a cytoskeleton, a skeleton in the muscle itself of these actin fibers. And if there's stretched and stretching, the dystrophin protein senses the distortion of the enclosure of the muscle. And then the Titan senses the extension of the muscle. That means you want to really go to a full stretch. If you did curls and never fully stretched, you'd have a little tiny muscle. You've got to stretch the muscle out. Goldberg's work and all kinds of work on muscle shows that full extension, you lengthen the muscle too. A lengthened muscle is stronger and fuller when it's contracted and it's faster. So I go, I want my muscles to be not too big, lean. Long and quick, the”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Do I have some sense of fatigue, but what I do is I push it up really fast and quickly, in a very precise form, lots of acceleration and then coming down really slow. And to a full good stretch, you have to remember we have this giant protein in your muscles, this Titan protein. It's the stress sensor. And stress, by the way, will stimulate MTOR and protein synthesis. Yes”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“No, I'm not because I may want to, I might do lakes and shovers one day and I might do almost never do curls because they're just ego muscles anyway. But I would just go around and do a variety of exercises. I make sure to hit everybody group a couple times a week and I'm cycling through and I do a lot of lat and lower back and legwork and shoulder work.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“It is to establish proper foster, but also To maintain it and to have sort of the nobility of having good posture. It really makes a difference in your mental attitude.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“If you need to look down, just look down over your cheekbones. Don't drop your head. You descend your head and the rest of your spot.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“But pastural muscles, they're slow twist fibers. You need to, they need to have endurance, keep your posture locked in. So in every workout standing against the wall, this was the thing that Naval liked most about my seminar. Standing against the wall, get a little slot in the small of your back, put your heels and butt against the wall, your shoulders back, your head back. Walk off and look over your cheekbones. Don't drop your head and start looking down. Your whole spine collapses.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“It's so mild you wouldn't believe it. I work off almost every day. Maybe 10-15 minutes. And sometimes it's hard to do a negative if you don't have a training partner, but I use equipment and I'll use Like, for example, lake extensions. Push up with two, lower with one, typical lake press, push up with two, lower with one. Shoulder presses. Push up with two. Actually, I use a machine. In this case, like the power hammer and stuff, I push it up with two hands and then lower it with one. And death which are all fast, which I'll mostly confess which fibers, so they really respond well to that.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“They double them, but they don't exhaust him. A lot of people, if you double the stem cells that flood out, you may exhaust them because you may simply exhaust them to ones in the niche. What you want to do is you want to double them and have one go back into the niche and one go out and heal tissues, asymmetric differentiation is what you want. If they symmetrically differentiate, they both become new possible progenitors to cells you're now exhausting. Take one out, put one in. It's the best way to do it in eccentric exercise does that. Downhill running does too.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“I'm doing eccentrics for really three reasons. The main one being that they double your stem cell counts in the satellite cells in the muzzle.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Well, I told Nasim to start doing negative deadlifts if he wants to improve his deadlifts. Have somebody help you put the bar up, lower it, pick a height, and then put it up again and lower it again and put it up again and lower it again. I do almost all negatives now.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Can you imagine the people with that dumb back in those days and there's still people around who think that energy balance model, I don't know how, well, let's face it, they all studied steady state exercise because you had put someone on the treadmill and you measured the oxygen expenditure. Nobody had any idea. Non-steady state exercise is very difficult to quantify and to measure. Now they're getting better at it. much better at it. The power of law holds again because the most intense exercise, the most intense expenditures to the bulk. You put acceleratomers on children. The leanest of the ones who engage in the most intense bursts. Little children don't steady state exercise.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Right, and this is just oil prices work and Latvia and others have looked at scientific publishing and what have you. The Pope is in his own version of this, by the way. Pope John Paul before he passed away, he was asked how many people work at the Vatican. He said, about half of them. And of course, Robert Evans just said the same thing about Hollywood. Hollywood's a place where half the people are not working. And it's true that between films and they're hoping for the next one and so forth. Even Dustin Hoffman is great. He said, I have to be grateful to be working. This goes with the business. In the industry, there are these power law distributed networks and a few people are at the central hubs. And so the same rule really holds for the movie industry, probably half the people do about 10% of the people do...”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“He was doing his three sets of 12 and so many hours on the treadmill or the cycling or whatever. And he figured out that in cycling to and from his office, that's when his office was some distance from his gym. He said he figured out that the maximum expenditure of energy in that ride was what did him the most good. And that's your approach, too. That's four hours. For example, in an organization, half the work is done by the square root of n workers. So you've got 100 people in there, 10 workers produce half the output.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“I used his book in a class I taught Fooled by Randomness I used in a class I taught on the economics of uncertainty. I told him I communicated with him I said I'm using your book I don't know why I wrote him but because I hate textbooks and that really connected with him he said he hates textbooks”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Yes, that's right. And so here he was doing. Just steady exercise. And I said, what are you doing? This is the wrong approach.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“My fault Well, you remember the story about Nassim, if you read the back section of the little section he wrote from my book because he Here he was a kurtosis traitor that as he used distributions with wild characteristics, he was buying out of the money calls and puts. And living on the variant.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“That's right. That's right. And they are not as, they don't rely as much on oxidation either. You're using the glycolytic pathway, which goes through to mitochondria anyway in the crypt cycle and so forth. But it's not producing lots of free radicals.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“You do weightlifting. You stay off the treadmill. Actually, if you sprint, you can use up, you can consume mitochondria because you improve mitochondrial dental.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“World, you can't survive unless you overeat during periods when food is available so as to store nutrients for the times of scarcity. We also overproliferate. That is, when nutrients are available, the transcription and translation process turns on in a sort of a burst. It has to be because otherwise you won't make enough proteins to survive. Your cells won't be durable. That is what's killing us today because we're over-transcribing, we're overeating. We're making too many proteins to get misfolded. They get damaged. There's no room for them. The architecture of the cell is stretched. The actin filaments are stretched out and there's stress signaling going on. And you don't transcribe accurately. You don't make good proteins when you're under stress.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“Well, whatever suits you, but I do lunch dinner because I want a long interval between meals. To promote proteostasis, I want to clear the enzymes. I want to remember, you've got. There are about a billion proteins in a cell, according to Dylan's group up at Berkeley. Oh, Berkeley. And it's very critical to the degradation of the proteins is sort of a continuous process, but the transcription in making new proteins is an interval-based kind of thing. It depends on when the nutrient signals are there when M torgin begins to say, okay, don't consume proteins, make new ones, transcribe and translate. Although when you transcribe and translate, you find that that moves up a diagonal, that the atrophy process follows it because you've got to keep some kind of balance there. My theory is this, that we had to overeat in order to survive. We don't live on energy balance. And if you look at this as a rent.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT
“The need to have high brain cognitive power to survive the ice ages, plus the growing settlement size on the seashore because we now had a stable source of food, we, I'm thinking of us, you know, coming from that period. And that spurred technology, and remember language developed at this time too. So it was an enormous change in human behavior during this time period.”
2017-05-12 · The Tim Ferriss Show · #239: How to Reverse Aging with Art De Vany · IDENTIFIED FROM THE TRANSCRIPT