YouSaid · the spoken record

Dr. Benjamin Bikman

lines on the record: 209
first: 2025-02-06
most recent: 2025-02-06
sittings or episodes: 1
sources: podcast

Every line below is reproduced as it was said and linked to the record it came from. Nothing here is summarised or generated. Directory · Search · Corrections

“Not agreeing to I don't know if that's true. And again, I would cite that one case report I just mentioned now, which is a man who did this, they reported that the microbiome was identical, that there was no significant change.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“And no one can prove that wrong. As much as I just stated that comment in a speculative fashion, it's speculative because there's no evidence. This is why I look at the microbiome and just say, yeah, it appears to matter but in ways that we don't know.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, so the fiber is so fiber will, but again, That's not the only thing bacteria can eat. Bacteria can eat fats, bacteria can eat amino acids. They can eat glutamine, for example. Even meat will have a little bit of glucose in it where the muscle has something called glycogen. And so there's trace amounts of glucose and even the meat that you're eating. I do not look at the argument that you're destroying your microbiome that has no scientific support. You may be changing your microbiome, but who's to say that's a bad change? Maybe it's a better change. You certainly are feeling better. You're thinking better. You're getting leaner. Your insulin sensitivity is improved. Cognition's improved. I would argue if there is a change in your microbiome, it's probably one that's for the best.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, but Stephen, but even then, there's a bit of an assumption built into the question because it's, do we know that the microbiome will be less diverse? The case study I just mentioned found that in this one single man, it didn't change his microbiome at all. It was the exact same populations in all the same proportions.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Your microbiome is intact, those bacteria do not die, they're just simply metabolizing other things. Maybe they're relying more on short chain fatty acids. Maybe they're relying more on amino acids. They're not eating fiber, but there's still stuff in the meat or the eggs that the microbiome will eat.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Months, I think. The problem with the microbiome, the reason I don't take microbiome research too seriously as a scientist is that it is a big black box. You came from the UK to London, to LA, to California. If we took a microbiome sample analysis of your time in the UK, now it would be different now. Even though you're eating the same, but you're drinking different water, you're breathing different air. I was just on a plane from Utah to California. Give me a day or so, I would have some sort of shift in my microbiome. So the microbiome can change in response to all kinds of things. The idea that you somehow have decimated your microbiome because you aren't eating fiber is absolutely false. That is completely false. Now, there might be a change in some of the population of your microbiome, more of one, less of another, but there's no evidence to suggest that's probably.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“No. Well, he had been eating plants, so the case study was a person eating a normal diet of plants and meat, a normal omnivore diet, and then looked at the microbiome and then adapted to a purely carnivorous diet, purely meat. And the microbiome didn't change at all.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Ah, yes, well, what a naive thing to say, if I may gently reprimand your friend. There is no evidence to support that there's any harmful change in the microbiome. In fact, a paper was just published that looked at a man who went from a normal omnivorous human diet with abundant plant matter to a purely carnivorous diet, literally zero carb, and they documented precisely no change in his microbiome, none whatsoever.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“It would take us a very long time to clear that glucose from our blood, much longer than otherwise. Like let's say we go out with the production team, they're eating a normal higher carb diet. All things equal, same body size, same activity, their glucose levels would come up and down in ninety minutes, perhaps. Yours and mine may take one hundred eighty minutes to come back down. So the person may say, well, gosh, Stephen and Ben are no longer burning glucose very well. And that's true. In that one moment, our bodies had almost forgotten what it was like to burn a bunch of glucose because we had adapted to fat burning.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“It could be that you start, you acutely or you temporarily become less metabolically flexible. Now that's me invoking a term we haven't brought up yet, but metabolic flexibility is a term to refer to the body's ability to when it eats glucose to burn glucose. When it's not eating glucose, it burns fat. So you're shifting between the two metabolic fuels that we outlined earlier. When someone has been adhering to a ketogenic diet for some time, it's almost as if their body is stuck in fat burning mode. And that if you and I, being in such adapted ketogenic state as we are, if we were to go to lunch and eat two bagels and a sugary drink.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“The only downside I can articulate, so in fact, I didn't even finish because I distracted myself, mentioning some of the benefits of ketones, but ketones are further anti-inflammatory, like they directly reduce inflammation in the body by inhibiting inflammatory processes, and they also improve antioxidant defenses so it helps reduce oxidative stress. So ketones do have benefits that go beyond even what we've taken the time to articulate. If there's any negative to a ketogenic diet,”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“And what I find is if I increase my fat, I always get plenty of protein, but if I increase my fat content, I have an easier time maintaining my bulk.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Eat more fat. Like every time you're making a steak, put butter on there. And when you're drinking a cup of coffee as crazy as it sounds, I drink Yerbamate every morning. I will put a big dab of butter A big dab of butter in my tea, and I'm sipping on it while the world's still asleep and the kids haven't woken up yet. And so I know because I want to keep my muscle as a guy who's almost 50. I find that during my strict ketogenic phase and I'm currently in it as well, every January I go to kind of a carnivore diet. And I mostly do it to one, lean down, but also to check any addictions and habits. I don't like feeling addicted to things. And my wife will comment. And even as an almost 50-year-old, it's fun to see my six-pack coming. I don't want to lose my mass, my muscle mass, because you have to work so hard to get it.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Well, and you might have been, but it could have been that you were simply not eating enough calories. So this is an instance where”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“To glucose to feed the brain, so my comment then getting finally getting to my answer is in your version of a ketogenic diet, with your level of muscle mass and your inherent metabolic rate based on your body size and your activity, you probably ought to eat more fat.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“If you don't have enough fat to burn to make enough ketones and the brain is saying All right, well I wanted the switch to ketones so that I could spare the glucose but I can't there's not enough ketones here so I have to rely one hundred percent on glucose but if you're not eating glucose now the body has to start stripping the protein from muscle and it sends those amino acids to the liver then the liver is so capable it will turn those amino acids into glucose”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“But then too it's possible that you were eating too few calories to actually maintain muscle. Muscle is a hungry organ. It is metabolically expensive for the body to keep that muscle on. And as you start to get leaner and leaner, it gets harder and harder for the body to defend that muscle. In fact, that's the difference between fasting and starvation. The longest known evidence of a fast was a man in the UK who fasted for three hundred eighty four days. Literally not eating or drinking a single calorie. He was under medical supervision, getting vitamins and minerals and water, and he went to live on, went on to live a perfectly healthy life. So what was the difference? Why was that not starvation? Starvation is when you run out of fat. So you might have gotten to the point of so lean that you didn't have enough fat to burn to make enough ketones to fuel the brain.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“drinking more because you will be urinating more, which is partly why people's blood pressure gets so good so quickly, and just to pause on that point, if someone is on one or two blood pressure medications and they adopt a ketogenic diet, they usually have to stop their medications within two days because their blood pressure goes to normal so quickly that if they stay on the medication they're going too low. So one could be that you were actually working out a little less”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Two things happening, possibly. Now I'm speculating here and I'm pretending to be your coach or your expert here. One could have been that you had relatively lower energy during your workouts because of a slight degree of dehydration. And then the other one would be calories, which I'll come back to in a moment. I just wanted to put it out there. So when insulin comes down, one of the many effects in the body is that another hormone comes down called aldosterone, which is one we've never invoked yet. But low insulin leads to lower aldosterone. And aldosterone comes down. The kidneys become much begin to eliminate salt and water much more rapidly. Now that's not problematic, but it does mean that a person does have to focus more on hydration and salts. So if someone's going on this strategy and they exercise fairly often, you need to be much more focused on your hydration.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Okay, so first of all, let me just add a hearty amen. I'm an advocate of a ketogenic diet, although it can be applied differently across different people. But I would say anyone would benefit from having some modest period of time of elevated ketones, at least in some portion of the day. Now, how do you maintain muscle mass in the midst of such obvious weight loss? I can only speculate. Now there are peer reviewed studies that I can cite which do support the idea that a human can be on a cutogenic diet and have a total maintenance of muscle and strength. That is published, so we know it's possible, although that doesn't seem to be what happened with you. I would suspect that there were two things.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“That if you want to lose fat, you need to burn fat. You're not going to lose fat if you're always burning glucose. It's fat that you need to burn. And as you start burning more fat, you realize that it's like the hump on a camel. That hump exists because it is a big source of fat for that animal to be using its own fat for energy. We have our own version of that. You think about the average individual who's chubby, they have hundreds of thousands of calories waiting to be burned in those fat cells. It's just that they're chronically elevated insulin is never letting them burn it. And so as the person starts making these changes in their diet to lower insulin, they now can finally start relying on their own fat for fuel, so it's no surprise that their hunger starts to come down. Let that be the natural way in which you're controlling your calories. Don't control your calories because you're forcing yourself to be hungry and eat less.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“If you're thinking, I need to be on a fat cell shrinking journey, let the first step of that journey be, I'm going to lower my insulin. Means I'm going to control my carbohydrates. I'm going to stop eating carbohydrates that come from bags and boxes with barcodes. And while I am restricting those carbohydrates, I'm going to focus more on protein and fat, so control carbs, prioritize protein, and don't fear the fat that comes with those proteins. Fat and protein together is a miraculous combination of helping you feel full. And it is literally giving everything you need. There are such things as essential proteins. There are such things as essential fats, so focus on those. And that will be the key to helping insulin come down. Then, as you have found, you haven't, and when you're hungry, eat. If you're not hungry, don't eat. But what the person will find is they're lowering their insulin all while their metabolic rate is going up. They're learning how to burn their own fat for fuel. Because remember, the metabolic hybrid, that metaphor”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Normally it's connected sort of one to one wherever body weight is going metabolic rate is going, except in these people. That method of dramatic weight loss through such severe restriction, which is based purely on the caloric theory of obesity, leads to significant hunger, so no surprise if a person's attempting to shrink their fat cells or lose weight if the first step is I'm going to cut my calories and they don't address their high insulin, they're never going to lose weight in the long run. They're going to step right back to where they were. Because if they start cutting calories, but insulin is still high, that's going to make them very hungry because insulin wants to be storing energy. A professor from Harvard named David Ludwig found this. If you have people eating a lower calorie meal that spikes their insulin, it makes them much hungrier than a lower calorie meal that doesn't spike insulin. So that's the key. Anyone listening?”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“They do. In fact, a paper published in the US from the National Institutes of Health documented not only the degree to which they gain weight back, but also how it almost literally breaks their metabolism, that normally a person's metabolic rate is connected to their body mass, a bigger body has a higher metabolic rate, a smaller body has a lower metabolic rate. This is just human physiology. And no surprise when someone loses weight, there's less of body, and so metabolic rate goes down, as they gain weight back, metabolic rate will typically go back up as well, except for the contestants and the biggest loser. They started with a high metabolic rate because of a high body fat level. They lost a substantial amount of weight, no surprise, metabolic rate went down substantially. But this is such a dramatic change that as they started gaining weight back, metabolic rate did not come back with it. It stayed lower than it should have.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Christmas dinner as hungry as possible, you would eat a little less in some period of time before the event, and you would exercise a little more, and it would work, you would be very hungry. That's why the traditional advice given for weight loss doesn't work, because we tell people eat less, exercise more. Sure, you maybe lose a little bit of weight in the short term, but all that does, you've given them the perfect recipe to promote hunger, and hunger always wins. As a good example, in the US we have a game show, maybe there was some version of this in the UK called The Biggest Loser. It was essentially who can lose the most weight? And it was through a punishing regiment of caloric restriction. Eat less, exercise more. That is like the perfect embodiment of that approach. They were starving and they were exercising to insane degrees. And oh my goodness, did they lose a lot of weight? And yet you never see them again. They don't do a reunion tour five years or ten years.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“So, the power there is like if you'll allow me to kind of springboard off of that comment, the power of, so if someone is listening to this and they're thinking, okay, I need to shrink my fat cells. Unfortunately, they don't realize that there's two variables to what caused their fat cells to grow in the first place. They have no awareness of the value of insulin in this formula. All they do is pay attention to the calories, and so the average individual is looking down the road of this fat cell shrinking journey, and they're thinking, okay, what I have to do is just cut my calories. And what do they do to cut their calories? They do the exact wrong thing. And before I even answer that, let me just present the scenario. Let's imagine that Stephen and I, everyone listening is invited. Stephen and I are hosting a buffet. We have the world's best chefs. It is going to be a table filled with the most delicious foods you can imagine. You're in our invitation, we say come hungry, because you're going to want to try a little bit of everything. Everyone listening, ask yourselves, what would you do to come as hungry as possible? You'd probably do two things. Or think, how did you go to your Thanksgiving or your Christmas?”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“I mean, that is just proof positive that you're in ketosis, which itself is proof positive that you're burning a lot of fat. And three, their insulin levels are low.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Well, that's where we have to speculate. There's no my lab published animal evidence suggesting that yes, indeed, it makes you sharper, that we had these animals navigate mazes and recognize objects, and when the animals were on a ketogenic diet, they were much sharper, they were much quickly, much better at solving problems and remembering solutions to previous problems.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, yeah, so it would result, so you're drinking it in, you're immediately absorbing it from your gut. So, if you are not in ketosis, let's say you had, and I'm not encouraging people to do this, you had just eaten two bagels and a cup of sugary coffee. No ketones, undetectable, because insulin has come up, it's inhibited ketone production. And then you drink a shot of the ketone within an hour we would detect your ketones. They would have gone up maybe to one millimolar, which is a pretty significant bump. and they're capable of that kind of movement, and maybe you do so because you're thinking, I really need to be sharp right now.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Then you have the bioidentical BHB or the bioidentical ketone, one company which is original ketone, they make it. Now, these ones are more effective. You take a little bit of these and you will get an increase in ketones. They're a little more expensive too. But as the space is becoming more competitive, the price is coming down.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Well, there's a bunch of different types. If you look at the spectrum of ketones, on one end you have the cheapest, most readily available, although less effective, called ketone salts, where it takes a molecule of ketone and binds it to a mineral like calcium or magnesium. Not as effective, and it's a lot of mineral, so people will find that they may get a lot of plaque on their teeth. Maybe increased risk of kidney stones, so comes with some consequences. Then you have the ketone ester, which often comes in shots.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Because it is just another fuel. It is something that the body can burn, that we always say, well, once you start running out of glucose, you're going to bonk or you're going to hit the wall. Well, what if you don't really use glucose because you're burning a lot of fat and a lot of ketones instead? And that keeps your glucose kind of untouched, or you're not relying on the glucose. And we see this in humans. If there's a human that has adapted to a ketogenic diet, they burn fat at a higher rate than was ever thought humanly possible. That fat is basically fueling all of their muscle movement during the exercise session rather than relying predominantly on glucose. The body has adapted. It's burning fat for fuel, and when available, it's burning ketones for fuel, and it's leaving the muscle as sort of a last resort when it really needs a big kick.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Ketones are basically the way to tell the brain saying brain, you think you need a lot of glucose? And if you don't get enough glucose, you would start stripping the protein from muscle to turn it into glucose. But I'm here as a ketone, so you can eat me instead and leave the muscle alone. So we published again a direct report finding that ketones actually make muscle more resistant to injury. And this could be why you're seeing more and more elite athletes using ketones as an actual ergogenic aid or like a supplement to help them better be better. So at my university at BYU just this year are men's and women's cross country team took the national championships, the best college runners in the nation. Pretty impressive. One of the things they do is they take these ketone drinks before they train and before they race. Some more and more of the Tour de France teams take ketone supplements.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yes, absolutely. And that is what happens. There are very well done controlled studies to show that if you control for all calories, when a human is in ketosis or metabolic rate goes up, your whole body is just burning more. It's just everything's kind of been turned on a little more. The furnace of the metabolism has just been have a little more fuel kind of stoking the fire. So ketones will increase metabolic rate of fat tissue. We found a paper that we published documenting how we took muscle cells and kind of insulted the muscle cells to determine how tough the muscle cells were. When we incubated the muscle cells with ketones, they were much more resistant to injury. So the ketones act to protect muscle tissue. And in a way, that is reflective of a function.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“So that means that the fat was suddenly behaving in a much more energetic way, that fat tissue has a very low metabolic rate, and that all of a sudden when the ketones came into them, they started getting much more active and they started burning more energy, which is going to be very helpful for someone who wants to lose fat. If your fat cells now have a three times higher metabolic rate, that means that the fat cells are starting to act a little bit more like your muscle cells. And they're just burning more energy.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Elevated. We pulled out small pieces of belly fet and measured the metabolic rate of that belly fat. And we found that in ketosis, the metabolic rate of that belly fat was three times higher than when the people were not in ketosis.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Them like one example is you ask the patient with Alzheimer's to draw the face of an analog clock, a circle with one, two through twelve, and then some hands on it, and it is utter chaos. This is published reports. You then put them into ketosis, ask them, can you please draw the face of a clock? It's still sloppy, but it is absolutely the face of a clock. You ask them when they're not in ketosis to try to tie their shoelaces. They can't think through the puzzle of tying the shoelaces. Ask them to do it again when they're in ketosis, all of a sudden they can tie their shoelaces. More than that, they can get themselves dressed. All of these are published case reports. It's just my long winded way of saying the brain thrives when it has ketones as a fuel source, but the benefits don't stop there. My lab published a report finding that when humans were in ketosis, which is just a term for ketones being elsewhere.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“And that excess, if you will, is what becomes ketones. So ketones are kind of a metabolic release valve, for the liver cell to say, I can't, I don't know what to do with all this fat burning. Okay, I know what I'm going to do. There's not a lot of glucose coming in. And so the brain may start to get hungry, so I'm going to start making ketones. And so ketones are nothing more than a product of a lot of fat burning. And anyone who even fasts for 24 hours, you wake up that next morning, you're in some degree of ketosis. Lest anyone think it's an extreme thing. People are going in and out of ketosis ideally often. Now why do I say ideally? It's because ketones are, as we've already outlined, perhaps the best fuel for the brain. The brain thrives on ketones. You can take a person with early stage Alzheimer's disease and have them go through a series of cognitive tests and they do horribly honest.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Well, it's acting, yeah. So, in this sense, it's doing it to help replace the glucose that isn't coming in. That's the value of the ketone. So as the liver is continuing to burn fat, it essentially gets to a point of fat burning where it's burning more fat than it needs.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Something interesting starts happening at Deliver. So the liver with insulin being low is burning a lot of fat, including its own fat that the liver can store, the liver can store fat, but also fat coming from fat cells. Because if insulin is low, the fat cells are just leaking out fat to be burned by the body. And because insulin is low, the liver keeps burning it. And the liver essentially burns, continues to burn so much fat that it fills its own needs, it meets its own needs and says to itself, hey, I don't need to keep burning fat. I have all the energy I need. I'm doing great, but it can't stop burning fat because insulin is low. And if insulin stays low, fat burning keeps going.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yes, so we could hook you up to something called an indirect calorimeter in measure that your RER, the respiratory exchange ratio, the balance between CO2 and oxygen, would go higher. So we increase your insulin. Like if I infused you with insulin in the next few minutes, we would see that your RER would go up. We'd say, boy, you're sugar burning, or we allow insulin to come down, and then the RER goes down, which is reflective of fat burning. So it's insulin that determines whether the body is sugar burning or fat burning. Now, when insulin has been low for about sixteen or so hours?”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Measured this in the whole body level by measuring the amount of oxygen and CO two that the body is producing, because different biochemistry or the burning of the fuels will produce a different amount of CO two.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, yes. So this is an opportunity for me to do a little bit of nutrient biochemistry or a little discussion of metabolism so that people appreciate what ketones even are and where they come from. So the entirety of the human body is a metabolic hybrid in that the body is largely burning fuel from two sources. It is burning blood glucose or sugar, blood sugar, or it's burning fat. Those are the two main fuels for the body by extension. Now the brain was an exception. The brain is glucose or ketones, but I'll get to where the ketones come from. The rest of the body isn't really relying on ketones as much as fats or glucose or blood sugar. Insulin is what decides which fuel is used. So as much as the metabolic engine has two fuel sources, insulin will decide which one is opened and which one is closed.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“That can come from plastics and soaps and detergents like BPA or diethyl stilbestrel DES, that's actually an estrogen mimetic, kind of what we'd referred to earlier with regards to other endocrine disruptors, but there are other chemicals that a person can drink or inhale, like I mentioned earlier, but that will directly impact the growth of fat cells or to tell, mimic what insulin wanted to do, which is tell the fat cell to grow.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah. So there are the ones that you inhale, a handful of inhaled particulates will matter. We have shown in my lab alone with my collaborators diesel exhaust will do it, cigarette smoke will do it, and more we have a funded grant right now to look at the effects of vaping. So apparently stuff we breathe will matter. To some unknown degree, things that we drink will that are non caloric. So there can be people have heard of the microplastics. Microplastics are things that you can't. They're so small that you drink them and they will absorb through the intestine and get into the bloodstream for reasons that are unknown to me at the moment. One of the sites where those microparticles will go is the fat cells. Once there, they will directly promote the growth of the fat cells. So that's actual microscopic segments of plastic, but separate from that are molecules.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Exactly. Yes, thank you for pointing it out. But again, as much as you and I are citing the problem with the correlational study there, we need to always cite the problem with correlational studies when it comes to informing nutrition policy, like don't eat eggs because they cause diabetes. But when you actually look at the studies, you find nothing of the sort.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, in fact, this evidence would suggest that it goes beyond theory. So our evidence would state conclusively that, yes, what you breathe does matter, then theoretically we would say, well, how much does that apply to humans? That is where it would get into the realm of theoretical. But the evidence certainly suggests, yes, the very air we breathe matters. And you see this at a population level. Look in areas where there are, now there are confounding variables here. Here I am invoking correlational research and I was just criticizing it a moment ago with regards to longevity. But you look in areas where they have higher pollution levels, where the particulates are higher in the atmosphere. And those same areas are always fatter and more diabetic.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Where we could perfectly control how much diesel exhaust they're getting. So we have this mechanism through in Paul's lab where you can aerosolize these particulars and know exactly how much the animal's breathing. And then at the end of the study, after even though they ate the exact same amount of food, the animals that were exposed to the diesel exhaust particulates had fatter fat cells and more insulin resistance than the animals that had just been breathing normal room air.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, that was one of the studies I just was referring to with regards to my colleague Paul Reynolds. Paul and I, that was one of the papers we published looking at these inhaled particulates. The reason I was interested in this field of study in the first place was just to continue to kill the caloric model of obesity. And this touches on an earlier part of the conversation. Overwhelmingly, if you ask someone why do we get fat? Well, because you eat more calories than you burn. Why do you lose fat? Because you eat fewer calories. And I have long just been frustrated by how naive that view is. Yes, energy matters, but again, the fat cell must be told what to do with the energy that it has. That, of course, points an obvious finger at insulin, which is the strongest of all signals, but what we found in that study is that even something as seemingly unrelated as diesel exhaust particles, mind you, we did not do this study in humans. Full disclosure, we did the study in animals.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Oh, that's a great question. It doesn't because it replaces other interests. So if the cigarette smoker ate the way everyone else was eating, it would. But because the cigarette smoke satisfies a craving, they have less of an interest in food. What's so interesting about cigarette smoking is, again, as I said, you begin to smoke, other things don't tempt you as much, like the cookies and the cakes. But one of the ways the smoker helps kick the habit of cigarette smoking is actually eating candy. Like they will literally start carrying around little candies in their pocket, so does they feel a craving for cigarette smoking they will take out a little candy, open it up and pop it in their mouth, and so it's no surprise that very commonly when a person quits smoking they gain significant weight. They end up trading out their addictions, if you will, and unfortunately, in humans, all of the study of addictions with food people only manifest.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT