YouSaid · the spoken record

Dr. Benjamin Bikman

lines on the record: 209
first: 2025-02-06
most recent: 2025-02-06
sittings or episodes: 1
sources: podcast

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“Oh, that is a very good question. I have, in fact, published now multiple papers with a very good friend and colleague who is a lung expert at my university guided by the name of Paul Reynolds. Paul and I, we have published reports together looking at cigarette smoking and the inflammatory and insulin resistance effects that come from that. And now we've even started looking at the molecules, the hyperheated molecules from vaping. They're terrible. In fact, yes, very similar results. If you were to take a comparable amount of the chemicals from normal cigarette smoke with its filter versus vaping, the vaping ones are probably worse chemical for chemical.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“So they found that if you took healthy non smoking people and had them start smoking, they became insulin resistant. I believe I invoked that study in the section where I was talking about inflammation, where when you cigarette smoke that elicits, there's a lot of junk coming in and there's a powerful inflammatory response in that contributes to insulin resistance.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, well, you say that, and yet maybe our anticolesteral view is the bizarre one. And so, as a cynic who's very familiar with biomedical research, I sometimes will look at clinical markers and say, why are we so obsessed with glucose? Why not insulin? Why are we so obsessed with cholesterol? Why not triglycerides, which is another lipid that can be measured that is far more predictive of who's going to have a heart attack or not? And I think it's because we have chosen markers in modern medicine that we have well designed drugs. So it's a really, really good way to sell a lot of drugs. So there's no drug that's going to address insulin. So let's not measure it. But there are lots of drugs that will lower glucose. So let's measure glucose because then we can diagnose the problem and then we can give them a drug and make a lot of money. That's a cynical view, but I don't think it's unjustified, similarly with cholesterol. Why look at LDL when triglycerides, another lipid marker, are a much better indicator. It's because we don't have a drug that affects.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Well, that's as the story goes, yes, and yet I think that's overly simplified, where people will say LDL cholesterol is the bad cholesterol, and yet that gets included in these studies of longevity. So I think that good and bad aspect of it is not entirely fair or accurate. We need LDL. And LDL is just as much a component of the immune system. LDL actually helps the body fight infections. So it's also an unsung hero of immunity.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yes, that's right. That's what the Sweden study found, for example. The paper just published a year or so ago, what were some of the most consistent themes that had good glucose control and high cholesterol. I'm a great defender of cholesterol. It is a molecule of life. So much depends on it. Mitochondria, for example. Mitochondria have to have a cholesterol molecule in them in order to work, like the very powerhouse of the cell. And the more you lower cholesterol through, say, drug interventions, the more you compromise the mitochondria. The sex hormones, all sex hormones are built on cholesterol. It's no surprise if someone takes a cholesterol lowering medication or sex hormones go down. This is why some men experience such terrible loss of libido because he's becoming low testosterone because of the war on cholesterol.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“But they attempted to document what were the variables that were just the most consistent theme of people who lived very long. One of them was good glucose control, and this next one is very controversial because they found that they also the longest lived people had high cholesterol levels. And isn't that funny it is one of the most consistent themes of longevity research that the longest lived people have higher cholesterol, and yet we live in a world that hates cholesterol in the moment cholesterol goes up, we put them on a cholesterol lowering medication. We could be doing the perfectly wrong thing to help these people live longer. So that was, and then low uric acid, and there's a handful of other little variables that fit into this.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“That's right. Yeah, in fact, most of the longevity research was sort of a final point on this, is that when you look at these studies that look back in time and say, okay, what is it about these people? What variables tend to go along with the longest-lived humans? One of them is that they're insulin sensitive and their blood glucose levels are, in fact, a very well done study just last year out of Sweden. I think it was just one year ago. They looked at all, and Sweden is meticulous in its record keeping, which is an advantage in a fairly homogenous society, so it kind of eliminates some confounding variables.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“But rightly so. I mean, ketones are a very vilified, misunderstood part of the body. And to my great delight, it's getting a sort of new appreciation.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“breaking cycle within the cell, that hey, it's time to get rid of some old parts and I will rebuild some of that again. Now we're going to break down these parts and rebuild it. Insulin is the key to that process. If insulin stays high for too long, you never allow the catabolic or the breakdown. This is one reason why insulin is so facilitative to cancer. Insulin wants things to grow. Cancer is a disease of growth. We don't ever let the cancer start to break down. Insulin won't let it in part”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Autophagy probably does matter for longevity. All the more reason to keep your insulin in check because insulin is a powerful inhibitor of autophagy, so as much as we have longevity gurus who are taking thousands of dollars worth of supplements, I can't help but look at that and think just control your insulin, that within every cell there's this battle, there's a yin yang of growth and death, or building and breaking, to say it a little more politely. In fact, that is metabolism. The very word metabolism encompasses anabolism, which is anabolic or building up in catabolism or catabolic, which is breaking down. The key to a healthy, growing living cell is this nice ongoing balance of build and break, build and break. You have to build something up and then modestly break it down, and then you build some things up again.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Then the question comes Well how can I control autophagy? Well there is a humble hormone that comes from the pancreas that has a very powerful effect on autophagy called insulin so as much as people are fasting what's the value of fasting in reducing autophagy it's because insulin comes down Now what becomes interesting is what happens if you were to put someone allow them to eat calories, but the calories are such that their insulin is staying low and they're making ketones in other words a ketogenic diet you also enable autophagy there is a very well done animal study finding that they didn't have to restrict calories and fast the animals they could let the animals eat as much as they wanted but it was a ketogenic diet they lived significantly longer than their other litter mates that were eating the normal high carb chow, similar to what humans eat nowadays.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, that's, yeah, yeah. In fact, yes. So that is partly why fasting has been so embraced within the longevity community. It's because if you can promote longevity or autophagy rather, if you can promote autophagy, the cell keeping itself cleaned out, that is thought to be a key contributor to longevity.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“They would live fifty percent longer or some fantastic increase in how long the animals lived. That kind of gave birth to the idea of fasting being beneficial, but it also allowed her lab to start playing around with some of the genes of these little insects, and when they started knocking down or underexpressing some of the genes involved in insulin They didn't have to restrict the food the animals just lived longer, and so that touches on this metabolic aspect, and everyone nowadays is really interested in autophagy. Autophagy is a term for a cell essentially cleaning itself out.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah. So, my view on longevity is a metabolic view, no surprise. I am a metabolic scientist and I don't mind someone sort of smirking at me declaring that or admitting it, but I'm somewhat justified just by way of setting the stage the earliest the birth of the modern longevity research if it didn't start it was heavily influenced by the work of a woman named Cynthia Kenyan KENYON CYNTIA Kenyan was one of the kind of she really did, in my mind, kind of give birth to the modern longevity focus. What her lab found using an insect model, and this is again a problem with the longevity gurus, is that they rely on insect data, for example, but it was compelling what she found. I think it was worms she found in worms that if they restricted the glucose that the worms were eating”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“You answered the survey. You may lie, you may not remember, you may have things that you don't even think about including, like, for example, that you're part of a very well put together religious organization. And I actually use that example very deliberately because people who are known to be part of good tight social circles like a formal religious group always live longer than people who don't. Maybe you're really lonely. Loneliness is a greater contributor to death than cigarette smoking, and it's not even close. So there could be things on that survey that you just cannot capture. And yet we end up making a conclusion. And so all of that correlational evidence is deeply flawed research. And yet that becomes the basis for the longevity guru to determine diet.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Well, a correlational study is by my estimation some of the weakest evidence that you can ever generate. A correlational study would just have someone come to your home and say Stephen, can you please answer this survey about what you eat”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Longevity expert or not a scientist but a guru and I don't mean for that to be negative but it does have a bit of a negative sound to it is that you have to rely on what I would call weak evidence now what do I mean by that so all of the approaches to longevity nowadays rely on either correlational studies or basic research or animals and insect studies and then extrapolating that results or assuming those same results will apply to the human so let me briefly just mention my concerns with correlational research so the longevity guru will say Correlational evidence suggests that people who eat meat die more.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Right, right. Well, I want to address this because this is a real person, so I want to address it very politely and diplomatically. I think that I want to distinguish the difference between longevity, research, and science, which is a very real living breathing field, and I'm proud to know individuals who are longevity scientists, and distinguish them from longevity, you said poster child, so the gurus of longevity. And that's not the same thing. So what I say, I don't mean to it to be an indictment of longevity research, but I don't mind if people hear a bit of an indictment in my voice of the modern longevity guru approach. So these individuals, and he is certainly the most well-known, they do have the advantage of never really being able to be proven wrong. So there's an inherent problem here. But I will say that the application of being a”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Like the belly fan. The belly fat, and from one animal to another, you couldn't do this in humans. If you move belly fat, if you will, or subcutaneous fat from one animal to the other, the animal is very healthy. It's no problem. Subcutaneous fat is inert. It really is just sort of hanging out there and mining its own business. But in that same study, if you move the visceral adipose over, now all of a sudden that animal that got that extra dose of visceral fat is going to become sicker. It's going to become more insulin resistant and diabetic because you've increased its visceral fat, the amount of fat that it has in that space. The body wants to limit the amount of fat that it has there because if the fat again, if the fat grows too much, you can physically start compressing and squishing organs that you need to be functioning, like the kidneys and the intestines.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, so just to be clear, if we took what they did in the study, just to reflect of FET are harmful. And so the human body has two distinct fat depots. And you and I described them, subcutaneous, which is the fat beneath the skin, or visceral, which is the fat tucked within the organs of the abdominal space. And if you move subcutaneous fat to”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“They once did as well. Although over the past few years, life expectancy actually turned down for the first time in the history of modern world. So who knows if it will continue to go up? But yeah, it could be people are living longer. I mean, one of the effects of modern medicine is that people live longer with disease, Alzheimer's included. But it's absolutely a consequence further of our overall metabolic milieu that we put ourselves in a position where we are making our brains insulin resistant and thus they're going hungrier and hungrier.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yes, and so the problem with visceral fat is this is such a finite space. There's so little room within the core of your body that if we allowed those fats to multiply, it could theoretically start physically compressing on tissues. And so those fat cells only grow through hypertrophy, which is the thing we talked about earlier with slow insulin resistance, subcutaneous fat cells are more abundant but smaller, visceral fat cells”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, so the fat beneath the skin. Yeah, the loose belly fat, the fat that can pinch and jiggle. That fat has a greater ability to make new fat cells. So as much as earlier you and I said fat cells remain static, for the most part they do, there's a little bit of wiggle room where it can go up That's purely subcutaneous”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, so Caucasians, so let's say Northern European African both store more of their fat subcutaneously, which is the fat just beneath the skin, or the fat that you can pinch and jiggle. That has an ability to expand more because there's nothing really to limit it. However, the other place for people to store fat is their visceral adipose, which is the fat that is tucked within the abdominal cavity, so tucked around the organs. It's sort of surrounding the kidneys and the intestines and the liver. That is an unhealthy place to gain fat, but in East Asian, all things equal is putting much more fat there than they are subcutaneously. The advantage of subcutaneous fat is that.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“A body is going to have a rate at which it can store fat in a healthy way, and then once that threshold is met, any further pressure to store fat will start creating insulin resistance. And that threshold is essentially how big, how many fat cells do you have and how much room do they have? So if you have more fat cells, you have a higher fat threshold. You can get fatter before it starts to hurt you.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, so on that ethnicity, if now there's a lot of kind of wiggle room here, but on one end, we'd have Caucasians, blacks would be right nearby. African ethnicities would be quite close to the kind of northern European ethnicity. And then we would move through, and I don't mean to miss anyone here, but on the other end, it would be East Asian and then sprinkled through that would be Latino. Latino would be somewhere in the middle, kind of Hispanic, and then other Southeast Asian and then East Asian, kind of on the worst end or the least sensitive or the most sensitive to their fat, the most sensitive to their fat. This actually is a concept that has been presented called the personal fat threshold, which is this really interesting idea born from a group in Australia suggesting that across every individual body, which of course is heavily influenced by both ethnicity and sex, like we had mentioned earlier”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, so they're more you like to find a Japanese man who's as fat as the average American, boy, you're gonna have to look. It's hard. It's hard. But to find a Japanese man who is just as much likely to get diabetes, type 2 diabetes, very easy.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Well, that's the second part of that statement is not true. They are more resistant to obesity, but they are, like, it's an interesting dichotomy.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“I bet her insulin would be high. And so all that would mean is, which is good. I mean, knowledge is power. And my hope would be that as someone goes and gets their insulin measured, and there are a handful of other tests they could also look at, but that's the most succinct, then it would be all the more impetus or encouragement to say, okay, I heard, I listened to Stephen and Ben, I really do need to start making some changes. And even in PCOS, there are reports that document the absolute reversal of the disease with nothing more than just dietary changes.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Oh, for sure. And in fact, I wouldn't be surprised if she does because the fact that she has PCOS is not absolute evidence but very likely evidence that she has insulin resistance, which would mean at any given moment her insulin is at the risk of being a little higher than her non insulin resistant counterparts.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yes, especially depending on the ethnicity. Like if someone listening to this is East Asian and they say, well, I'm quite thin, I don't have insulin resistance. You very well could. It depends. Even in young women, a group out of northern Canada, which is, of course, pretty far north, they found that even in young healthy weight women with PCOS, if they compared them to their identically matched other women without PCOS, they were more insulin resistant in the other group. So anyway, that's my way of saying even if you look at yourself and think, well, I'm kind of lean. I'm not insulin resistant. You very well could be.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Can get their insulin measured, get it measured. In US units, if it is anything above about ten micro units per mill, that's a warning. In UK units, if it's anything above about forty picamoles, that's a warning. Insulin is high, you could have insulin resistance.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Well, it is technically easy to measure. It's just that we don't have enough systems in place to enable it. Like again, if someone listening in the UK were to go to their GP and say, can you measure my insulin? In many instances, they literally can't get it done. The system just isn't in place to take it to the lab and measure it. Now, some do some physicians in the UK who do so, and they have developed their own way of getting it done, and they're incredible advocates of this whole idea. But it is harder in the UK and Canada, where the system is such that they have said out of ignorance, but perhaps well placed or well intentioned, they will say, well, insulin isn't a marker that matters. It is, and if you're measuring insulin resistance just to put things back to where we had talked about it earlier, many people with insulin resistance have normal blood glucose levels. It's the insulin that's high. And so I would say if a person”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Well, yeah, and that's just right. That's because there's not enough training, which is at the beginning of the conversation, you asked my mission. One of my missions is to help people learn what to look for.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“And another way of saying that is the one thing all of those seemingly unrelated brain problems have in common is that they all have some degree of insulin resistance. But then it's no surprise that they all benefit when ketones can swoop in to save the day, but that only can happen if the person is giving their body a break from the insulin long enough to actually start making ketones.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“glucose, and as much as you and I are describing that scenario as relevant for Alzheimer's disease, you can essentially open up the book of neurological disorders and see the same thing. Depression has a brain glucose hypometabolism to it. Migraines have a brain glucose hypometabolism. Epilepsy and Parkinson's disease. So all of these disorders of the brain, of the central nervous system, the one thing they all have in common is the brain isn't getting enough energy from glucose.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Not get all of its energy from glucose, and thus there's an energetic gap. And in the absence of ketones there's nothing to fill that gap, and the brain says well I don't have enough energy to keep functioning as well as I did before, so I have to reduce my function which manifests as a reduction in the ability to think and process, in other words, cognition goes down. But what's so interesting is I just got finished describing a scenario that scientists refer to as brain, glucose, hypometabolism, or a reduction in the amount of glucose the brain is using. There are scientists that measured this. We don't in my lab because we don't do these kinds of techniques, but you can actually infuse people with a glucose that you can take pictures of and see how much the brain is taking it in and metabolizing it. In Alzheimer's disease, the brain is not getting as much glucose, so they call that a hypo or a reduction in metabolism of.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“The blood like in type 2 diabetes, you would think well the brain can just get all the glucose it wants, and yet it cannot because it has insulin regulating the entrance of the glucose. And if the brain is insulin resistant, there's not enough glucose coming in. And thus the brain is forced to rely on the only other fuel that it can rely on, namely ketones, but the same person who's eating all the time to keep their blood glucose high all the time has so much insulin in their blood that they're never making enough ketones to fill the gap the gap and the brain has an energy gap now where the brain needs an amount of energy. And if there's a lot of glucose in a healthy insulin sensitive person, glucose will fill all of that need. But as the brain becomes progressively insolent resistant, it cannot.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“It just really sets it apart from everything else. And the brain is one of them. The brain has a very high metabolic rate. So this is a very hungry organ that needs a lot of energy all the time. But the brain is unique in that it primarily will only use two fuel sources. And I've mentioned them, namely glucose and ketones. But glucose in that section of the brain that gets compromised with Alzheimer's disease, the glucose can't just come straight in. It needs someone to open the door for it, and that is insulin, of course, just like we described with the muscle cell, where in order for the glucose to go into the muscle, insulin had to come and knock on the door, if you will, and then the muscle, being a polite, responsive host, would open and allow the glucose to come in. The brain is similar that in that section of the brain, it has doors that need insulin. It's locked until insulin comes and opens them. So even though glucose levels may be high enough.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Because the plaques had nothing to do with it. That's just something that some brains have. Some brains have more of these little specks than other brains and they don't contribute to Alzheimer's disease at all. Now, what kept rising to the top, and I would hope now is the dominant theory, is that people with Alzheimer's disease almost always have some detectable instance of insulin resistance, if not full-on diabetes type 2 diabetes. Now, I will say personally, I don't like the term type 3 diabetes because it makes it sound like it's a whole new version of diabetes. To say it more succinctly and accurately, it is simply insulin resistance of the brain. And the brain is a very hungry organ. It is in what I teach as a trinity of high metabolic rate organs, that there are three organs in the body whose metabolic rate is so high.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“And you would be just as likely to find plaques in both brains, so whether the brain had Alzheimer's disease or not, you would still see plaques in the brain. So the whole idea that plaques mattered has long been controversial, and just to put a fine point on it before transitioning to the metabolic origins about two or three years ago, they found out that the very first published papers that implicated plaque as a cause of Alzheimer's disease were based on fabricated data. So the scientists who published those first reports that led to the entire theory that Alzheimer's disease is placed were called out as fraudulent and indeed all of it was fabricated. So the entire idea that Alzheimer's, and we have spent billions of dollars on studies to try to determine how do plaques cause Alzheimer's disease, why when we reduce plaques, it doesn't appear to help the disease.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“These kind of little proteinaceous little thick things that are preventing neurons from sending the signals throughout the brain for the brain to think and have normal cognition. And yet there are those of us, and I am proud to say I have long been one of them, who has said that the plaque-based theory doesn't make sense. We have had drugs that have been available for human use for years that have effectively reduced plaques in the brain, and yet did nothing to improve cognition. So that is an immediate challenge of the plaque based theory of Alzheimer's. Even further, even beyond older than that evidence, when you would look post mortem or look at tissue donor people who'd passed away, you would look at the brains of people who died with confirmed Alzheimer's disease at the time of death, and look at the brain of someone who died without any evidence of any cognitive decline or any compromised thinking whatsoever.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Oh yes, yeah it is, in fact, it went from not being even on the radar to being a top ten killer. Now it's interesting how people even die from Alzheimer's disease. It's a very kind of vague death. But yeah, Alzheimer's disease is one of the top 10 diseases now, certainly in the West. And I would argue it's because it has a metabolic origin. Now, one of the interesting things about Alzheimer's disease is we have spent billions of dollars on Alzheimer's research trying to identify the plaque. So just to set the stage here so that people listening can appreciate this paradigm.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Insulin is promoting fat cells getting bigger, that high insulin is also accelerating the growth of the tumor cells because again the main one of the main mutations in breast cancer is a sevenfold, so a seven times increase in the number of insulin receptors and insulin wants to tell things to grow, so it's no surprise that almost every tumor that's ever been measured for having insulin receptors will have a lot more. It's basically telling its neighboring cells insulin's going to come by and it's going to tell us all to grow. I want to grow more than you. And that's what cancer is. Cancer is growth, unregulated growth, insulin tells things to grow. So the connection between obesity with the rising incidence of breast cancer is very, very likely a consequence of the rising incidence of insulin resistance.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, so as child rates, as childbirth rates are going down, it does increase the risk of breast cancer. Now, as I'm a cell biologist, right, I like to understand a direct mechanism. And so as much as I invoke the perhaps lower rates of childbirth among women, I don't know the mechanism, so I'm sort of loath to describe it. The mechanisms I'm very familiar with are the metabolic, which is if you take breast tissue that is tumor tissue and compare it to, like if you take a breast tumor and compare it to the normal tissue right next to it, like that it would have shared its origins with, the cancer from the breast will have seven times more insulin receptors than the normal breast tissue. So the idea of this tracking quite nicely with obesity rates going up over the past twenty years, I wouldn't say that it's the obesity per se, but I would say it's the entire metabolic milieu, which is the insulin resistance, that as much as the highest.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Very likely almost entirely driven by breast cancer. Breast cancer is the main cancer for women by far. And so if I had to guess, I bet almost all of this increase in cancer incidence is because of breast cancer. Why might that be going up? I would suggest there's probably a couple instances. One, although people might not appreciate this, is that one of the best ways for a woman to reduce her risk of breast cancer is actually having babies. It's very well known, very well documented that if a woman has babies and breastfeeds, her risk of breast cancer goes down. So, yeah, in fact, it's very meaningful. I actually don't know the reasons for it. It could be the changes in estrogens during lactation phase.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, yeah. Yeah. A few thoughts come to mind. Whenever I see these kinds of reports, I always make sure I look firstly at the what are they actually measuring? So just to set the stage, this is the number of women who are being diagnosed with cancer. So not dying from cancer, but it's going up. So one simple explanation, although perhaps the most disappointing, could be that more women are going in for testing younger. And so we're just seeing kind of an artifact of more women are just going in sooner and they're detecting a problem that they wouldn't have otherwise detected, you know, for 10 or 20 years, which is a good thing. You want to detect cancer as soon as possible. So that's the boring answer, that it could be a reflection of just more women going in for ultrasounds or MRIs or mammary scans, whereas men don't ever get tested for anything. Which is why we die more from everything, possibly. But to give a more exciting answer,”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yes, I mean, a significant thing. And I say that with all of the sympathy I can for the mother who may be struggling with this, but it is certainly a motivation for mom to just be mindful of what you're eating.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Oh, for sure it does, yeah. So think about it's almost like the baby is literally developing in a hyperglycemic, hyper insulinemic environment. So the baby gets hardwired to want to continue to exist in a state of high insulin and high glucose after the baby is born. And so, yes, the offspring of mothers who have gestational diabetes are significantly more likely to gain weight and be chubbier or fatter than their counterparts and to later develop type 2 diabetes, a resounding yes.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“That will compound the problem. Absolutely. So then she will go from the normal insulin resistance of pregnancy into the insulin resistance of diabetes. So it really is like type 2 diabetes, but a microcosm of it, a mini version that was really instigated or initiated because of the”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT