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Dr. Benjamin Bikman

lines on the record: 209
first: 2025-02-06
most recent: 2025-02-06
sittings or episodes: 1
sources: podcast

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“Yeah, it's a great question. Gestational diabetes is essentially type two diabetes of pregnancy. So it's perfectly timed question because If you look at the average woman who is very healthy, very insulin sensitive at the beginning of her pregnancy. So glucose is normal and insulin is normal. Over the course of her pregnancy, she stays normal, healthy, pregnant woman, which is to say she has physiological insulin resistance. She doesn't get diagnosed with gestational diabetes though, which means her glucose is normal, but to keep her glucose normal because she is insulin resistant, but for a purpose to help her body grow, her insulin levels are high, and the neglucose is still in a normal range. And then in some women, especially if she has a family history of type two diabetes, the insulin resistance goes too far.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Goodness, yes. Yes. So her body not only needs to grow tissue mass, like the uterus has to get much bigger. She has to grow a placenta. She also needs to become a little insulin resistant, to give a little more glucose to her baby, because she is after all now living for two people. And so as her body becomes insulin resistant, it actually facilitates the growth of the baby a little more rapidly. But as you noted, it helps her store more fat and progesterone is another hormone that even accelerates that process. But basically it's her way of her body's way of saying hey, I am committing to growing another human, and it's going to be metabolically very demanding. And so I'm going to have as much extra fat or much as much extra energy as I can in order to ensure that if there's any sort of scarcity in food that happens during the course of the pregnancy, I'll have enough energy to get through.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“It sure is. The breasts. Yeah. So in the woman, after she's finished puberty, the only other time of growth she'll ever have will be pregnancy. And so those are the two instances where the body has become insulin resistant to take advantage of the heightened scenario where it can grow.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“To grow. It is like a fertilizer in the body. Now sometimes it's misplaced and results in problems like increasing the risk of cancer, for example. But in other instances, if you have a young child who needs some explosive growth during puberty, well, then that's really helpful. Insulin's telling the body to store more energy, to build up tissues, including muscle and bone, but also including fat.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“So now I say that now, and someone would think, well, but you just, why would I want to hold on to energy in a way where it's causing hypertension in Alzheimer's disease and increasing the risk of heart disease? Not all versions of insulin resistance are negative. So there is what all the insulin resistance that you and I have been talking about is pathological insulin resistance or harmful insulin resistance. Insulin resistance that serves no good purpose and it's making us sick. However, there is insulin resistance in human development, which is physiological or helpful. It's supposed to happen. That's not always bad, because insulin wants to”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Oh, yeah. In fact, it's funny that you bring the question up again because I realized I didn't quite answer it that way. So insulin resistance, why would it exist at all? It would probably be a way for the body to know when it was needed to hold on to energy a little better.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, you can, but so the solution in that regard is the vegan must be educated enough to know what they're deficient in and then wealthy enough to afford the supplements to make up for it.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, yeah. So at least, among other things, at least it would be the essential omega-3 fats. So there are three omega-3s, and humans can only, we can only get one from plants, but it's one that the humans don't use. We need the other two, and they only come from animal source foods.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“It is, and you can cut it out. But it really is. It's a real thing. And why does depression go up so much when people stop eating animal source foods? It's because you are depriving the brain of what it needs.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“The brain has already switched to get the majority of its energy from the ketone, and so don't tell me that in this dynamic the brain prefers this one because this one's five times higher than this one, and even in that scenario the brain is already getting more than half of its energy from the ketone. So all of this is my long-winded way of saying when we look at the principles of evolution, one of the leading theories is this idea that we began eating essentially a meat-heavy diet that, again, is so nutritious that it allowed our brains to grow. Maybe one final point on this, although it is a bit of a barbed comment, people may find this somewhat amusing or disappointing or frustrating. The title of a book just published, which is that vegetarians have smaller brains. This is seen in humans that the less a human eats meat, then the smaller the brain becomes. The brain is so dependent on the nutrients.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“In response to ketones is the brain. The brain, the moment ketones hit the blood, stream, the brain immediately starts taking in ketones for a fuel. Very often I have students who have had a professor perhaps with the best of intentions but ignorant nonetheless, tell the student that the brain the main fuel for the brain is glucose, that the brain prefers glucose. And I show them just one or two papers to prove that wrong immediately. And it is reflected in this idea which if to use some convenient UK units, if blood glucose is five millimolar, that's a concentration, a way of measuring an amount of something. Blood glucose may be five millimolar or eighty milligrams per deciliter for the American audience. That would be a normal glucose. And if you and I were to fast for 24 or so hours, we may get up to about one millimolar of ketones. And yet even then,”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Shrinking because we didn't need them to be so big. Our brain was growing. And it's because it had so much nutrition, including ketones. So ketones are an extraordinary fuel for the brain. In fact, one of the reasons why a baby that is born premature will be more likely to have learning disorders later in life is because premature baby didn't have time to get very fat. And fat baby is healthy baby. And fat baby gets into ketosis. Let's say you If you took a six month old baby, that baby would be in a deeper state of ketosis in two hours than you and I would be in two days because the baby is burning so much of its beautiful chubby fat and the more the body burns fat the more it makes ketones and the tissue of the body that appears to benefit the most”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Our intestines became significantly shorter, so if you compare the human digestive tract to any other primate animal, if we are a primate, then if you look at the intestines, they are fantastically different, particularly the large intestine or the colon, because our ancestors, as the theory goes, began eating meat. We didn't need the colon as much because the colon is a place for food to ferment. And so if you're eating a lot of plant matter, like other primates do, you need a much, much larger colon. So we started eating food that was so nutrient dense. Our colon shrunk considerably. We didn't need to waste energy on a big, busy colon. At the same time, as we were eating food that was so nutrient dense and so loaded with good fat, it allowed us to have more time to be curious and explore, and so at the same time our intestines.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“There are some theories that are very interesting that attempt to explain why is it that we became so fantastically different from, let's say, our closest animal relatives other primates like chimpanzees or apes. What was the difference that had us become so different than them? One of the leading theories is a theory called the expensive tissue hypothesis. And it actually does have something to do with ketones. In the expensive tissue hypothesis, as the theory goes, our earlier ancestors deviated in this kind of animal family line because we started eating more meat. We started eating food that was so nutritious, so nutrient dense, so loaded with good calories and all of the fats and proteins that we need that it allowed two very distinct changes to occur in us compared to other primates.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“so determined to spend energy that it will both increase metabolic rate and it will make the energy the calories be wasted in the breath and in the urine and in the form of ketones because ketones have calories ketones are energy now we're just dumping them out into the universe”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, that's the total amount of energy that it just costs you and I to just live. Ris going through the day, but that's a significant amount. If you and I were to go exercise and say, let's go burn 300 calories, we got to be on the stair step for an hour or something. So it's 300 calories, but at the same time, if your insulin is low, you're burning so much fat that you start making ketones. And I don't intend to get onto that topic quite yet. But suffice it to say, every molecule of a ketone has a caloric load roughly similar to glucose. And one of the, and what the body, when it starts making a lot of ketones, it starts eliminating the ketones. So every time someone is breathing out ketones, they're literally breathing out calories, or they're urinating and they're urinating out ketones if they have higher ketones in their blood. They're urinating out calories because ketones have energy. And so this is the way that if insulin is low, it becomes impossible for the body to hold on to its energy.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“The other meal, same number of calories, but its lower carb higher fat. This lower carb higher fat version will have a lower insulin response. And they will store less fat from that meal. And someone would say, well, where do the calories go? You can't, it's the laws of thermodynamics. You can't destroy energy. The metabolic rate will go up. So when insulin is low, if you have someone going a full day, eating the same number of calories but lower carb calories, their metabolic rate will be almost three hundred calories higher in that day.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, yeah. So your body, now it would partly depend on, there are people where if all of your fat cells had reached its maximum point, then you're done. You're not going to gain more fat. You're just going to become more and more and more insulin resistant. So you kind of start limiting yourself. But there are studies in humans to show that if you give humans isocaloric meals, so the exact same number of calories, but in the same amount of protein, but you differ those meals based on the amount of carbs to the amount of fat, so let's say two meals exact same calories, 2,000 calories, or that's in one meal, that's too high, 1,000 calories in one meal. One version of this is the conventional way of eating, which is lower fat, higher carb”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“You're telling me to grow, but what am I going to grow with? That's where the calories come in. Now the fat cell will say, hey, fats and glucose in the blood, insulin has told me to get big and so I need to pull you in to help me grow. You're going to give me the bulk. And if you have one without the other, it is death.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Very much now if you so so a moment ago I said that the big fat cell is two variables you must have both you must have both a signal to tell the fat cell to get big which is insulin it is the there's no other signal that can do it you can in a human just simply take away the insulin like type 1 diabetes it doesn't matter any other hormone in the body it does not matter they cannot get fat they could again they can eat thousands they could eat ten thousand calories of chocolate cake they cannot get fat not only can they not get fat they can't hold on to their fat because if there's no insulin to tell the fat cell to hold on to it or get big it has to shrink it's breaking down it's fat so the body goes into such a dramatic fat burning state in the absence of insulin that keeping fat becomes impossible so the insulin signals necessary to tell the fat cell what to do but the fat cell will say okay insulin your high”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Fatter. If we checked them four hours later, It develops when fat cells get really, really big. It's like because they have to tell insulin, insulin, you continue, you are telling me to keep growing? I can't keep growing. I'm so big that I'm going to pop. I mean, literally, the fat cell can get so big that it degrades its membrane. It's like a water balloon that a knotty little boy has overfilled and it's about to burst. The fat cell doesn't want to burst, and so it tells insulin, insulin, you are trying to make me grow. You're telling me to grow? I can't listen anymore. I'm becoming insulin resistant to stop growing.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“and yet they stay really small until we add insulin. The moment we add insulin into that little petri dish, if we check those cells four hours later, they're immediately”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“She learns that wait a minute, I can eat whatever I want, and all I have to do is not inject my insulin, and I'll be as skinny as I want, and it works. It works so well that it's actually a formal eating disorder called diabulemia. So this fact that this exists is absolute proof that the growing and the shrinking of the fat cell is more complicated than just calories being high or low. Because like I'd said earlier when I talked about hormones, hormones are a way for the bot for the very tissues of the body to know what it ought to do with energy. And so a fat cell will have energy all around it, and if it doesn't have insulin to tell it what to do, it won't do anything with it. Or maybe to make this more direct, back home in my lab, my students are growing fat cells and petri dishes. These fat cells are swimming in a little sea of calories, lots of glucose, lots of fat.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“That, if they are skipping their insulin injections. In fact, this is so known that if you take, let's imagine a young woman who would maybe have more pressure to be thin than her male counterpart, although it's happening more in males too. Imagine a young girl who gets diagnosed with type one diabetes at the age of thirteen or fourteen. Very impressionable time. She's very worried about how she looks and how thin she is”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Particularly good in that speedo, anyway, but I just am bulging a little more than I was before, but otherwise I'm healthy. My blood pressure is fine, my blood sugar's fine, everything's normal. that same ten kilos of fat on Chinese Ben Hypertension type two diabetes fatty liver disease infertility and that is because Chinese Ben had fewer fat cells to start with and so those fat cells as the body was told to store fat those fat cells were getting much much bigger much sooner and the fat cell promotes insulin resistance very very readily and so that logically moves into the question of well what makes fat cells grow and it is two essential variables that we only ever look at calories and yet if you take a person with type 1 diabetes and say I want you to eat ten thousand calories but don't give yourself your insulin injection they cannot gain weight it is literally impossible for the type one diabetic to get fat”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“So very few fat cells, relatively speaking, across all the ethnicities. There are very few fat cells. A Caucasian on the other end of the spectrum, they went way higher. And so this guy, let's say American Ben versus Chinese Ben, overly simplified, but here we are. So much of fat mass isn't the number of fat cells, even though American Ben has more. It's the size of the fat cell. So I could be the same percent body fat really as Chinese Ben, but that would just be because my fat cells were just that much smaller. But this is the problem then. If you have, let's say, American Ben and Chinese Ben both gained ten kilos of pure fat over the next ten years very easily done. Most people do that quite often. Caucasian Ben just doesn't look as good in his speedo, which is a pasty Caucasian. He's not going to look at it.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Because it really becomes the person ends up, their vanity ends up really ruining their future metabolic outcomes. But there are differences across ethnicity. This is a little oversimplified, but not much. On one end, you'd have Caucasians, kind of Northern European Caucasians. On the other end, and you'd have East Asians, like Chinese, Japanese, Korean, East Asians. And then if you look at that same spectrum of people making fat cells through their life, an East Asian will be making fat cells and then stop right about here.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“That's really, really safe assumption for most people. Yeah, for most people, a fat cell, sometimes students will hear that fat cells are immortal. That is not true. But they're long-lived. Fat cells will live about 10 years. And so typically, by the time, if you think of, if you look at a newborn during infancy, childhood, and puberty, the number of fat cells is going up, up, up, up, up. Once they finish puberty, so mid to late teens for a young woman, late teens or even early twenties for a young man, usually at that point the number of fat cells they have is going to be very static.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“And yet, it's possible that I'm healthier metabolically than you. And that's because it's not the mass of fat that matters most. It's the size of the fat cell that matters. This is why women, despite universally being fatter than her male counterparts, are healthier with regards to insulin resistance in every single metabolic problem. It's because women, as a result of her particular sex hormones, have more fat cells, but they're smaller, so she has more fat, but smaller fat cells, and small fat cells are healthy, insulin sensitive, anti inflammatory fat cells. But the bigger the fat cell gets, the more it initiates a cascade of events or a series of events that creates insulin resistance.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Away because they never give themselves a break. But one of the concepts. But when insulin is high, it starts to have a signal on the fat cell, and that then brings us to the slow insulin resistance, where you have something happening in the fat tissue that begins to set the stage for insulin resistance in the entire body. And it takes longer to settle in, but it takes also longer to go away. That's why I called this one slow insulin resistance. Now in the case of insulin, most people, so the key with the, I'll explain it this way first. So the most relevant feature with fat tissue contributing to insulin resistance is the size of each fat cell. When we typically think of fat, we would maybe say okay, Steve has, I'll do this in kilos for the UK audience. Steve has ten kilos of fat on your entire body. That's probably too much for you. Ben has 20 kilos.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“What do we do? We wake up, we eat breakfast, we spike our blood sugar levels, and insulin has to come up. Insulin will take longer to come down than the blood sugar will. It will wait in the blood to make sure that all the blood sugar has gone back to normal, so depending on how much carbohydrate we ate for breakfast, it could take our insulin levels three or even four hours to come back down to normal. Long before it's had a chance to come back down to normal, we've had a mid morning snack, of course. We need to go get a sugary coffee and another bagel or something. And so after just a couple hours, we do it again. And once again, before insulin has had a chance to come back down, we have a starchy carbohydrate heavy lunch. Then an afternoon snack, and then a carbohydrate heavy dinner. And then, of course, we have to have an evening snack before we go to bed. So the average individual is spending every waking moment in a state of elevated insulin, and thus the signal never really goes.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, so at that, especially all of these can contribute to a more lingering insulin resistance, but especially insulin, where I focus on that one the most because of not only its relevance to the slow lane, but also just how present it is where 70% of all calories globally are carbohydrates. And now, perhaps with the best of intentions, our experts are telling us that we should be eating six times a day. And so we eat we wake up in the morning, insulin has finally been coming down while we've been fasting overnight. Insulin gets to take a little bit of a break. We're fasting. Then we break that fast by eating breakfast. And in the UK as it is in the US, by and large, this is going to be a very starchy sugary breakfast. It's toast with some jam or it's cereal or its begels, that is going to be, that is almost pure glucose.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“for attention This is like the body in response to insulin. If there is always insulin, it's always going up, always going up. The body will start to say the muscle cell will start to say boy insulin, you are knocking on my door all the time. This is getting old. I'm not responding anymore. I'm not going to listen as much as I was before. So in that sense, insulin, too much insulin becomes a cause of insulin resistance. And back to what I said earlier, I could take you into the lab, start infusing you with just a little drip of insulin to increase your insulin. And over just a few hours, you would become demonstrably less sensitive to it than you were before we started. Again, as I take that away, give your body a few hours and it's back to normal. In every one of those instances, it's a fast onset and it's also a fast solution if we can take it away.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“A cell, if it's capable, will try to become resistant to that stimulus. This would be like a funny analogy in the Bickman home, my darling wife is home with the children. That is what she wants to do. She is full time mom. When I'm home, and I try to be home as much as I can, it's funny for me to note the difference in how quickly we each respond to our children. I will hear my child saying Mom Mom, Mom and she's not responding. Mom has heard this for so much that she's become kind of selectively deaf when my children are demanding her attention. I'm not as around my children quite as much because I'm working during the day. It's a very fresh signal to me. I've not heard it so much that I've become deaf to it. And so I will respond even though I'm in the other room because I'm so much more sensitive to the clamor.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Molecules of insulin, so high insulin is both a consequence of insulin resistance, but it's also a cause. And this is reflective of a fundamental principle in all of biology that if there is too much of a stimulus”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“They will note on some days, like every autoimmune disease there is an ebb and a flow. Some days it's good, some days it's bad, and on the bad days, if you measure their insulin resistance, it is absolutely locked with the degree to which their immune system is turned on or off or higher or lower. So inflammation is another cause. And then the last one of the fast lane of insulin resistance is too much insulin itself. Now the astute listener will realize the kind of circular thing I've just presented by invoking high insulin as a cause of insulin resistance because they will also think, but wait a minute, Ben, you just said that high insulin is also a consequence of insulin resistance, that, you know, back to the bounce or knocking on the door of the muscle cell, if one bouncer wasn't enough or one molecule of insulin wasn't enough, the body will say, okay, well, let's send.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“So stress is a cause of insulin resistance. But then next is inflammation. You and I were commenting about earlier about how, boy, there's a cold going around. It's flu season. Even then, if a person were wearing a continuous glucose monitor on the back of their arm, measuring their glucose levels, they would see their glucose levels are much, much higher, like significantly higher during the time that they're struggling with this infection. That is a reflection of insulin resistance. Insulin's having a harder time keeping the blood glucose levels in check. Anytime inflammation is up, insulin resistance will be up as well. Even in things like autoimmune diseases, there are reports in humans that document the degree to which someone has, say, active rheumatoid arthritis. Their joints are achy because of an autoimmune attacking.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“That they both want blood glucose levels to climb. It's kind of their way of saying, hey, we don't really know what's going on right now, but we want to be ready to run away. That's the fight or flight kind of aspect to stress. And so they want to push blood glucose levels up, and they do very well. That, of course, puts them at odds with the hormone insulin. Because these two epinephrine or adrenaline and cortisol, the two stress hormones, they're pushing glucose up. Insulin wants to push it down. So the more the body is has those stress hormones elevated because of, say, sleep deprivation, that's a very effective way to increase cortisol, or they are taking too much, drinking too much caffeine. That is a way to increase epinephrine quite strongly. If both of those signals are too incessant or they continue to be present and climb, then insulin has to work harder and harder. And then we have insulin.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“If I remove those things, your insulin resistance would go away. So these are fast causes and they're fast resolution. They are stress is a primary cause of fast insulin resistance, so too is inflammation. And then lastly, and this is going to sound somewhat paradoxical, too much insulin is also a cause, and I'll end with that one because I think it's the most important than transition to slow insulin resistance. So anytime the body is experiencing too much stress, it will very quickly become insulin resistant.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Yeah, right. Yeah. So the origins are so important because it helps us understand why we've gotten into this situation we are, where it's the most common problem worldwide. There are two pathways to insulin resistance. So two roads that get to the same destination. Again, the destination being insulin resistance. There's the fast lane, which I call fast insulin resistance. It actually has three lanes, which I'll describe in a moment. Then there's the slow insulin resistance, which is a more, it takes a little longer to get there, but at the same time, it takes a little longer to get away from it. So I'll start with fast insulin resistance because the slow one ends up getting a little excitingly complicated, but in a cool way. I could take you to a clinical lab and I could make you insulin resistant in six hours with either of these three things. But as quickly as it settles in,”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“That tells the blood vessels that it's time to expand is actually insulin. And so this is what I said earlier, where insulin does so many things in the body, and we only think of it as being relevant to glucose, and that's not fair. Insulin does a lot of stuff, again, including telling blood vessels to expand. Now, unfortunately, in the case of this unfortunate man, his blood vessels become insulin resistant. So now it's insulin coming and knocking on the doors of the blood vessels saying, hey, it's time to expand and increase blood flow. But the blood vessels don't respond. They don't listen. So they stay constricted. Blood flow stays insufficient, and thus he has erectile dysfunction.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Perfect example of both of these parts of insulin resistance where in some instances insulin isn't working very well, always with insulin resistance blood insulin levels are higher. So for example, erectile dysfunction is the most common form of male infertility. In fact, its connection to insulin resistance is so strong that just a few years ago I was so struck by a title of a paper that had just been published which stated something like is erectile dysfunction the earliest manifestation of insulin resistance in otherwise young healthy men. Now what is the connection? It's because in a normal erectile function in order for the man to have normal erectile function he has to experience a pretty dramatic increase in the size of the blood vessels in his body. The blood vessels expand that increases blood flow and then he has normal function. Part of that signal”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Or one molecule of insulin, if you will, and it would open the door and let the glucose or the blood sugar come in. But now the muscle cell, the bouncer, insulin's knocking on the door, but the muscle doesn't listen. It's resistant. And so the body has adapted and it learns, okay, well, if one bouncer wasn't enough, let's send an angry mob of bouncers, and then the glucose, the muscle will start to open the door, and indeed it can. So those two problems go together. On one hand, insulin isn't working as well as it used to. That's what gives it the name insulin resistance. But there is another part that is equally present, which is that blood insulin levels are higher. Earlier at the outset of the conversation, I mentioned that even infertility has an origin, has some degree of development because of insulin resistance. And it's a perfect.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“The things insulin is trying to do, including lower blood sugar, it doesn't do it quite as well as it used to. Some of the cells or tissues of the body have become deaf to insulin's demands. Now, however, at the same time that's happening, insulin levels are higher, and that is really important. And I'll mention an example in just a moment that highlights the difference between the two, but we have to consider any time we talk about insulin resistance, we think of two things happening in concert. One, insulin isn't working quite as well as it used to in various places of the body. At the same time, insulin levels are higher, and that kind of takes us back to the muscle cell where I'd mentioned getting a little ahead of myself that a bouncer is knocking on the door and once upon a time the muscle cell would hear that one polite knock from that one bouncer.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“At the door, it's coming and knocking on the door of the muscle saying, Hey, muscle, I've got some sugar that wants to come in. And normally the muscle will say, oh yeah, sure, okay, open it up the doors and let the sugar come in. When the muscle is insulin resistant, the bouncer is knocking. Maybe there's even, I'm almost getting ahead of myself, but one bouncer, maybe two or three bouncers pounding on the doors of the muscle cell, but the muscle cell's not listening. It's become deaf. That's the insulin resistance of what we call insulin resistance, where some of insulin's effects, like helping lower blood sugar, it's not working very well anymore. And the muscle is just an obvious example because there's so much of it. It is the biggest issue on the average individual. Someone who's very obese perhaps now has more fat tissue, but even people who are overweight, most of us is muscle, so that's a good tissue to look at. So part of insulin resistance is that of all”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Well, not technically. Yeah, but just to sort of go with your metaphor, but maybe to use another one, insulin comes and knocks on the doors. It's like the bouncer.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Wrapped into one. The one problem is the most obvious one, which is that insulin isn't working as well as it used to. So back to the analogy of the taxis dropping off sugar, if the muscle tissue has become insulin resistant, insulin is coming and trying to pull the sugar loaded taxi into the muscle, but the muscle's not listening.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“If the liver sees sugar driving by in the taxi, it just opens the doors and lets it in. It doesn't need insulin to come and tell it to let the sugar in. However, even at the liver and every other cell has a similar degree of this, the liver doesn't know what to do with it. So this is back to something I'd mentioned earlier where insulin's thematic effect at the entire body is to tell the body what to do with energy. In all of its forms as these kind of caloric rich molecules, what to do with lactate, what to do with ketones, what to do with fats or glucose, what to do with amino acids, so insulin will tell the body what to do with all of those things, but again its most famous effect is to control blood sugar. And that's not wrong because it's most powerful activator is blood sugar. So with all of that in mind, insulin resistance is too problems.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Insulin will open the doors for blood sugar to come in and drive the taxi in mostly at the muscle and the fat. Muscle and fat tissue need insulin to come and bring the sugar in via taxi. However, other tissues and the brain a little bit as well, other tissues will still respond to insulin, but they don't need insulin to tell it what to do with the sugar. It just takes it in. But even on those tissues.”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT
“Perfect. Yeah, that's right. Look, it's a shuttle. It's a taxi saying, hey, glucose, come on in. I'm dropping you off at the muscle. So mostly, just as an interesting tangent of insulin before I finish answering insulin resistance,”
2025-02-06 · The Diary of a CEO · The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! ⁠The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman · IDENTIFIED FROM THE TRANSCRIPT